|
Chronic Kidney Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
<b>Abbreviations</b>: DR: diet restriction; MR: methionine restriction; SASP: senescence-associated secretory phenotype; AL: ad libitum; CKD, chronic kidney disease; AKI: acute kidney disease; TSP: transsulfuration pathway; CGL: cystathionine g-lyase; H<sub>2</sub>S: hydrogen sulfide; AMPK: AMP-activated protein kinase; mTOR: mammalian target of rapamycin; IS: indoxyl sulfate; CC: compound C.
|
31164038 |
2019 |
|
Kidney Diseases
|
0.040 |
AlteredExpression
|
group |
BEFREE |
<b>Abbreviations</b>: DR: diet restriction; MR: methionine restriction; SASP: senescence-associated secretory phenotype; AL: ad libitum; CKD, chronic kidney disease; AKI: acute kidney disease; TSP: transsulfuration pathway; CGL: cystathionine g-lyase; H<sub>2</sub>S: hydrogen sulfide; AMPK: AMP-activated protein kinase; mTOR: mammalian target of rapamycin; IS: indoxyl sulfate; CC: compound C.
|
31164038 |
2019 |
|
Colorectal Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1.
|
28757355 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1.
|
28757355 |
2017 |
|
nervous system disorder
|
0.050 |
Biomarker
|
group |
BEFREE |
1982), as well as the neurological disorder tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) (Gessain et al.1985; Rodgers-Johnson et al.1985; Osame et al.1986).
|
11488989 |
2001 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
5-Aza-dC reduced DNA (cytosine-5)-methyltransferase 1 (DNMT1) protein, reversed promoter hypermethylation, and restored TSP1 expression in five melanoma cell lines, while having no effect on TSP1 protein levels in normal human melanocytes.
|
23202046 |
2013 |
|
Colon Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
5-FU dose-dependently increased the expression levels of intrinsic antiangiogenic factor thrombospondin-1 (TSP-1) in human colon carcinoma KM12C cells and human breast cancer MCF7 cells.
|
18757417 |
2008 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
5-FU dose-dependently increased the expression levels of intrinsic antiangiogenic factor thrombospondin-1 (TSP-1) in human colon carcinoma KM12C cells and human breast cancer MCF7 cells.
|
18757417 |
2008 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
5-FU dose-dependently increased the expression levels of intrinsic antiangiogenic factor thrombospondin-1 (TSP-1) in human colon carcinoma KM12C cells and human breast cancer MCF7 cells.
|
18757417 |
2008 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Herpes simplex virus type 2 glycoprotein G-negative clinical isolates are generated by single frameshift mutations.
|
10559290 |
1999 |
|
Anaplastic astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Anaplastic astrocytomas expressed moderate levels of TSP-1 and TGF-beta.
|
11132930 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumors with a high expression of TSP-1 showed a higher MVD and the correlation between TSP-1 immunoreactivity and microvessel density was highly significant (P=0.003).
|
11253112 |
2001 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human T cell leukemia virus type 1 (HTLV-1) causes two major diseases: adult T-cell leukemia-lymphoma and tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM).
|
12176150 |
2002 |
|
Canarypox (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Canarypox virus was used as a vector for the rabies glycoprotein G gene.
|
1351126 |
1992 |
|
Human T-cell lymphotrophic virus, type I [HTLV-I]
|
0.010 |
Biomarker
|
disease |
BEFREE |
Human T cell lymphotrophic virus type I (HTLV-I) is the etiologic agent of adult T cell lymphoma/leukemia (ATLL) and tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM).
|
1517966 |
1992 |
|
Human papilloma virus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
HPV infection was detected in 11 of 24 cases (46%), and TSP-1, RASSF1-A and p16 genes were hypermethylated in 46%, 42% and 38% of the tumours, respectively.
|
18336597 |
2008 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Herpes simplex virus (HSV) glycoprotein G (gG2) has been used as the basis of many serological assays for the detection of HSV type 2 (HSV-2)-specific antibodies.
|
19369475 |
2009 |
|
Metastatic melanoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Metastatic melanoma in liver grew more rapidly in Tsp1-null mice compared with controls, whereas in lung grew similarly in Tsp1-null mice or controls.
|
20103648 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor THBS-1 mRNA expression level was significantly related to lymph node metastasis (P = 0.031), tumor size (P = 0.021) and patient age (P = 0.005).
|
22231149 |
2012 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human T cell leukemia virus type 1 (HTLV-1) is associated with a neurological syndrome named tropical spastic paraparesis/HTLV-associated myelopathy (TSP/HAM) and the disease progression involves viral factors.
|
23800288 |
2013 |
|
Congenital Thrombotic Thrombocytopenic Purpura
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Congenital thrombotic thrombocytopenic purpura (TTP) is a rare form of thrombotic microangiopathy, inherited with autosomal recessive mode as a dysfunction or severe deficiency of ADAMTS-13 (A Disintegrin And Metalloprotease with ThromboSpondin 1 repeats Nr.
|
26272487 |
2016 |
|
Dyslipidemias
|
0.010 |
Biomarker
|
group |
BEFREE |
Dyslipidemia regulates thrombospondin-1-induced vascular smooth muscle cell chemotaxis.
|
26350564 |
2015 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Herpes simplex virus (HSV) type-discriminating antibody tests (glycoprotein G (gG) directed) are used to identify naïve persons and differentiate acute infections from recurrences.
|
26755775 |
2016 |
|
Aortic Aneurysm
|
0.030 |
Biomarker
|
disease |
BEFREE |
AAA growth was negatively correlated with serum TSP-1 concentration (<i>Spearman's rho <sup>-</sup>0.129, P</i>=0.033).
|
28364044 |
2017 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Herpes simplex virus type-2 (HSV-2) specific glycoprotein G (gG-2) is widely used as the antigen of choice for serodiagnosis of HSV-2.
|
29104048 |
2018 |