SNCA, synuclein alpha, 6622

N. diseases: 36; N. variants: 44
Source: CURATED ×
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		0.900 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		0.900 GeneticVariation GWASCAT Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. 19915576 2009
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		0.900 GeneticVariation GWASDB Genome-wide association study reveals genetic risk underlying Parkinson's disease. 19915575 2009
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		0.900 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815 2012
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		0.900 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815 2012
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		0.900 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		0.900 GeneticVariation GWASDB Identification of a novel Parkinson's disease locus via stratified genome-wide association study. 24511991 2014
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		0.900 GeneticVariation GWASCAT Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815 2012
dbSNP: rs104893875
rs104893875
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0752347
Disease:
Lewy Body Disease 		0.860 GeneticVariation UNIPROT The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. 14755719 2004
dbSNP: rs2736990
rs2736990
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.860 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815 2012
dbSNP: rs2736990
rs2736990
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.860 GeneticVariation GWASDB Identification of a novel Parkinson's disease locus via stratified genome-wide association study. 24511991 2014
dbSNP: rs2736990
rs2736990
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.860 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
dbSNP: rs2736990
rs2736990
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.860 GeneticVariation GWASDB Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. 20070850 2010
dbSNP: rs2736990
rs2736990
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.860 GeneticVariation GWASDB Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. 20711177 2010
dbSNP: rs2736990
rs2736990
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.860 GeneticVariation GWASCAT Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. 20070850 2010
dbSNP: rs356220
rs356220
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		0.850 GeneticVariation GWASCAT Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. 22451204 2012
dbSNP: rs356220
rs356220
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		0.850 GeneticVariation GWASDB Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. 22451204 2012
dbSNP: rs356220
rs356220
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		0.850 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815 2012
dbSNP: rs104893877
rs104893877
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. 9197268 1997
dbSNP: rs104893877
rs104893877
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. 23457019 2013
dbSNP: rs104893877
rs104893877
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity. 24936070 2014
dbSNP: rs104893877
rs104893877
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. 9462735 1998
dbSNP: rs104893877
rs104893877
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. 14755719 2004
dbSNP: rs104893877
rs104893877
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions. 25561023 2015
dbSNP: rs104893877
rs104893877
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT A novel α-synuclein missense mutation in Parkinson disease. 23427326 2013