SNCA, synuclein alpha, 6622

N. diseases: 36; N. variants: 44
Source: CURATED ×
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104893875
rs104893875
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0752347
Disease:
Lewy Body Disease 		T 0.860 CausalMutation CLINVAR
dbSNP: rs104893877
rs104893877
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		T 0.800 CausalMutation CLINVAR
dbSNP: rs104893878
rs104893878
Entrez Id: 6622;644248
Gene Symbol: SNCA;SNCA-AS1
SNCA;SNCA-AS1
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		G 0.800 CausalMutation CLINVAR
dbSNP: rs104893877
rs104893877
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0752347
Disease:
Lewy Body Disease 		T 0.760 CausalMutation CLINVAR
dbSNP: rs431905511
rs431905511
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		T 0.700 CausalMutation CLINVAR
dbSNP: rs356182
rs356182
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		G 0.740 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci. 28892059 2017
dbSNP: rs104893877
rs104893877
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT A novel α-synuclein missense mutation in Parkinson disease. 23427326 2013
dbSNP: rs104893878
rs104893878
Entrez Id: 6622;644248
Gene Symbol: SNCA;SNCA-AS1
SNCA;SNCA-AS1
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT A novel α-synuclein missense mutation in Parkinson disease. 23427326 2013
dbSNP: rs104893875
rs104893875
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.700 GeneticVariation UNIPROT A novel α-synuclein missense mutation in Parkinson disease. 23427326 2013
dbSNP: rs201106962
rs201106962
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.700 GeneticVariation UNIPROT A novel α-synuclein missense mutation in Parkinson disease. 23427326 2013
dbSNP: rs104893877
rs104893877
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. 9462735 1998
dbSNP: rs104893878
rs104893878
Entrez Id: 6622;644248
Gene Symbol: SNCA;SNCA-AS1
SNCA;SNCA-AS1
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. 9462735 1998
dbSNP: rs104893875
rs104893875
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.700 GeneticVariation UNIPROT Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. 9462735 1998
dbSNP: rs201106962
rs201106962
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.700 GeneticVariation UNIPROT Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. 9462735 1998
dbSNP: rs104893877
rs104893877
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. 23457019 2013
dbSNP: rs104893878
rs104893878
Entrez Id: 6622;644248
Gene Symbol: SNCA;SNCA-AS1
SNCA;SNCA-AS1
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.800 GeneticVariation UNIPROT Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. 23457019 2013
dbSNP: rs104893875
rs104893875
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.700 GeneticVariation UNIPROT Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. 23457019 2013
dbSNP: rs201106962
rs201106962
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C1868595
Disease:
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) 		0.700 GeneticVariation UNIPROT Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. 23457019 2013
dbSNP: rs1372518
rs1372518
Entrez Id: 6622;644248
Gene Symbol: SNCA;SNCA-AS1
SNCA;SNCA-AS1
CUI: C2985280
Disease:
Blood Protein Measurement 		C 0.700 GeneticVariation GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
dbSNP: rs2737002
rs2737002
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C2985280
Disease:
Blood Protein Measurement 		G 0.700 GeneticVariation GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
dbSNP: rs2736990
rs2736990
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.860 GeneticVariation GWASDB Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. 20711177 2010
dbSNP: rs356220
rs356220
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		T 0.850 GeneticVariation GWASCAT Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. 20711177 2010
dbSNP: rs356220
rs356220
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		T 0.850 GeneticVariation GWASDB Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. 20711177 2010
dbSNP: rs356168
rs356168
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
CUI: C0030567
Disease:
Parkinson Disease 		0.710 GeneticVariation GWASDB Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. 20711177 2010
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease 		0.900 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815 2012