|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The polymorphisms of R130Q (rs20541) and -1112C/T (rs1800925) in IL-13 gene were associated with significantly increased risks of asthma in overall analyses.
|
22222605 |
2012 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The minor allele T of rs20541 in IL13 is the risk allele for asthma but the protective allele for psoriasis.
|
22694930 |
2012 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In the present study, we confirmed the association of rs1800469 in TGF-beta1 and rs20541 in IL-13 with asthma and found a trend toward association between rs2241712 in TGF-beta1 and rs2070874 in IL-4 with asthma among atopic subjects, suggesting TGF-beta1, IL-4 and IL-13 may be associated with the susceptibility and development of asthma in this Chinese population.
|
22053598 |
2011 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
IL13 Arg130Gln (rs20541) and G870A (rs1295685) were consistently associated with asthma and serum IgE in both asthma populations.
|
20484924 |
2010 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We show that IL13 rs20541 and rs1800925 are each significantly associated with self-reported asthma and allergy, and that this association is not confounded by any of the known developmental and environmental risk factors for asthma and atopy, including in particular place of birth.
|
19254294 |
2009 |
|
Asthma
|
|
0.800 |
GeneticVariation
|
BEFREE |
IL13 encodes IL-13, a Th2 cytokine, and rs1800925 and rs20541 confer risk of asthma.
|
19554022 |
2009 |
|
Dermatitis, Atopic
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.
|
23886662 |
2013 |
|
Multiple Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
ALLERGIC RHINITIS, SUSCEPTIBILITY TO
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
ASTHMA, SUSCEPTIBILITY TO (finding)
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our findings suggest that IL-13 SNP rs20541 is significantly associated with AR risk in Asians but not in Caucasians.
|
29687183 |
2018 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our aim was to observe factors associated with IL13 rs20541 polymorphism and other factors with or without allergic comorbidities such as subject-reported allergic rhinitis (AR) and/or allergic conjunctivitis (AC) symptoms in adult asthmatics.
|
28273659 |
2017 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
Gene-environment interactions between IL-13 (rs20541) and antibiotics or mold may play a role in AR.
|
24973272 |
2014 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
Association of interleukin-13 SNP rs20541 (Arg>Gln) to allergic rhinitis in an Asian population of ethnic Chinese in Singapore.
|
23954258 |
2013 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
When stratifying for race, IL-13 SNP rs20541 exhibited increased AR risk in Asians (Gln versus Arg: OR=1.20, 95% CI=1.06-1.36; Gln/Gln versus Arg/Arg: OR=1.57, 95% CI=1.17-2.12; Arg/Gln+Gln/Gln versus Arg/Arg: OR=1.22, 95% CI=1.04-1.44; Gln/Gln versus Arg/Gln+Arg/Arg: OR=1.45, 95% CI=1.09-1.93), while no significant association was detected in Caucasians (Gln versus Arg: OR=1.28, 95% CI=0.93~1.78; Gln/Gln versus Arg/Arg: OR=1.42, 95% CI=0.96-2.11; Arg/Gln+Gln/Gln versus Arg/Arg: OR=1.35, 95% CI=0.89-2.05; Gln/Gln versus Arg/Gln+Arg/Arg: OR=1.37, 95% CI=0.93-2.02).
|
23545317 |
2013 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
However, a recent meta-analysis using data from these 6 studies has shown that the A allele of IL13 SNP rs20541 was associated with an increased risk of allergic rhinitis, whereas no such relationship existed between IL13 SNP rs1800925 and allergic rhinitis.
|
22023794 |
2011 |
|
Allergic rhinitis (disorder)
|
|
0.070 |
GeneticVariation
|
BEFREE |
We conclude that there is evidence for an overall association between IL13 SNP rs20541 and increased risk of AR, especially in mixed-age populations.
|
21309855 |
2011 |
|
Glioma
|
|
0.060 |
GeneticVariation
|
BEFREE |
There may be a weak association between the IL-13 gene rs20541 polymorphism and glioma susceptibility, and the associations may be different between ethnicities.
|
29402849 |
2018 |
|
Glioma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present study aimed to determine whether polymorphisms in IL-10-1082A/G, IL-12p40 1188C/A, and IL-13+2044G/A (rs20541) are associated with the incidence of glioma in Iraqi patients.
|
26516307 |
2015 |
|
Glioma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Nine polymorphisms in genes within the IL-4/IL-13 pathway (IL-4 rs2243250, rs2070874, rs2243248, IL-4R rs1805011, rs1805012, rs1805015, rs1801275, and IL-13 rs20541 and rs1800925) were assessed for their relationship with glioma risk by computing odds ratios (ORs) and corresponding 95 % confidence intervals (CIs).
|
25472582 |
2015 |
|
Glioma
|
|
0.060 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the IL13 rs20541 but not the IL-4Rα rs1801275 polymorphism may be a genetic predictor for gl</span>ioma.
|
23395224 |
2013 |
|
Glioma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggests that the IL13 rs20541 polymorphism contributes to susceptibility to cancer, especially for glioma; and the IL13 rs1800925 polymorphism may be associated with glioma risk.
|
23246181 |
2013 |
|
Glioma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In the single-locus analysis of the 23 examined SNPs, 1 pro-inflammatory and 2 anti-inflammatory gene SNPs were significantly associated with glioma risk (COX2/PTGS2, rs20417 [OR = 1.41]; IL10, rs1800896 [OR = 1.57]; and IL13, rs20541 [OR = 0.39], respectively).
|
20406895 |
2010 |
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
For rs20541, the results suggested an association between rs20541 and COPD risk in Caucasians under the recessive model (OR = 2.79, 95% CI: 1.13-6.92, Pz = .026), whereas this SNP was not associated with COPD in Asians.This meta-analysis suggests that the T allele of rs1800925 is associated with the increased risk of COPD in both Asians and Caucasians, whereas rs20541 is associated with the risk of COPD in Caucasians but not in Asians.
|
29381928 |
2017 |
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Association was found between IL-13 gene SNPs (rs20541 and rs1800925) and an increased risk of COPD.
|
24286397 |
2013 |