Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 134
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 95
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 88
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 58
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 51
CXCR4 P61073 C-X-C motif chemokine receptor 4 G-protein coupled receptor 1.8E-02 0.362 0.923 49
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 47
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 40
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 39
TNFRSF1A P19438 TNF receptor superfamily member 1A 0.99 0.409 0.923 33
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 33
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 22
TAC1 P20366 tachykinin precursor 1 0.75 0.424 0.923 19
CALCA P01258 P06881 calcitonin related polypeptide alpha Signaling 1.6E-02 0.416 0.923 18
ABL1 P00519 ABL proto-oncogene 1, non-receptor tyrosine kinase Kinase 1.00 0.432 0.923 17
HLA-DPB1 P04440 major histocompatibility complex, class II, DP beta 1 Immune response 5.3E-10 0.453 0.923 9
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 83