Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
IL6 P05231 interleukin 6 0.32 0.248 0.962 177
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 112
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 134
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 85
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 60
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 71
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 59
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 94
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 95
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 88
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
LEP P41159 leptin 0.46 0.349 0.846 78
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 77
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 71
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 17
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 67
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 41
REN P00797 renin Enzyme 2.4E-07 0.370 0.923 12
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 55