Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor signaling molecule 0.80 0.263 0.966 1640 21
IL6 P05231 interleukin 6 0.34 0.287 0.966 1330 16
CSF2 P04141 colony stimulating factor 2 signaling molecule 0.84 0.356 0.966 670 3
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 1035 15
IL10 P22301 interleukin 10 6.5E-03 0.320 0.931 961 17
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 847 25
APOE P02649 apolipoprotein E 1.7E-03 0.352 0.931 770 39
TLR4 O00206 toll like receptor 4 5.6E-09 0.359 0.931 674 25
IL4 P05112 interleukin 4 5.3E-03 0.364 0.931 615 10
NFKB1 P19838 nuclear factor kappa B subunit 1 1.00 0.365 0.931 611 25
IL1A P01583 interleukin 1 alpha 1.5E-04 0.366 0.931 596 11
IL2 P60568 interleukin 2 0.49 0.373 0.931 564 4
NOS2 P35228 nitric oxide synthase 2 1.5E-14 0.385 0.931 531 17
SOD1 P00441 superoxide dismutase 1 oxidoreductase 0.13 0.406 0.931 456 47
LAMC2 Q13753 laminin subunit gamma 2 enzyme modulator; extracellular matrix protein; receptor 3.6E-12 0.419 0.931 400 30
MPO P05164 myeloperoxidase oxidoreductase 6.8E-15 0.435 0.931 327 15
RAC1 P63000 Rac family small GTPase 1 enzyme modulator 0.71 0.470 0.931 226 11
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 1773 306
VEGFA P15692 vascular endothelial growth factor A signaling molecule 2.7E-05 0.298 0.897 1174 32
IFNG P01579 interferon gamma 0.47 0.323 0.897 901 6
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 835 60
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 1.00 0.338 0.897 832 24
HLA-DRB1 P01911 P01912 P04229 P13760 P13761 P20039 Q29974 Q30134 Q30167 Q5Y7A7 Q95IE3 Q9GIY3 Q9TQE0 major histocompatibility complex, class II, DR beta 1 defense/immunity protein 1.0E-03 0.347 0.897 719 26
CCL2 P13500 C-C motif chemokine ligand 2 signaling molecule 0.62 0.353 0.897 691 5