Source: GENOMICS_ENGLAND

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
OTULIN Q96BN8 OTU deubiquitinase with linear linkage specificity 0.22 0.751 0.346 2
AP1S3 Q96PC3 adaptor related protein complex 1 subunit sigma 3 Transporter 1.6E-02 0.711 0.385 2
COPA P53621 COPI coat complex subunit alpha Transporter 1.00 0.700 0.385 2
DNASE2 O00115 deoxyribonuclease 2, lysosomal Enzyme 4.5E-04 0.700 0.462 4
IL36RN Q9UBH0 interleukin 36 receptor antagonist 3.4E-08 0.638 0.538 3
PSTPIP1 O43586 proline-serine-threonine phosphatase interacting protein 1 Cellular structure 2.5E-06 0.650 0.577 3
RNASEH2B Q5TBB1 ribonuclease H2 subunit B 3.3E-09 0.595 0.615 6
LPIN2 Q92539 lipin 2 5.0E-05 0.628 0.615 6
USP18 Q9UMW8 ubiquitin specific peptidase 18 1.5E-03 0.601 0.615 3
SH3BP2 P78314 SH3 domain binding protein 2 1.2E-11 0.623 0.654 2
RNASEH2A O75792 ribonuclease H2 subunit A Enzyme 4.2E-03 0.592 0.692 5
MVK Q03426 mevalonate kinase Kinase 0.17 0.576 0.731 8
RNASEH2C Q8TDP1 ribonuclease H2 subunit C 5.5E-03 0.590 0.731 5
ACP5 P13686 acid phosphatase 5, tartrate resistant 7.9E-02 0.561 0.731 3
POLA1 P09884 DNA polymerase alpha 1, catalytic subunit 1.00 0.653 0.731 2
SAMHD1 Q9Y3Z3 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 6.5E-13 0.547 0.769 7
NLRC4 Q9NPP4 NLR family CARD domain containing 4 9.9E-12 0.556 0.769 3
NLRP1 Q9C000 NLR family pyrin domain containing 1 5.0E-19 0.502 0.769 2
STING1 Q86WV6 stimulator of interferon response cGAMP interactor 1 1.2E-03 0.522 0.769 2
SLC29A3 Q9BZD2 solute carrier family 29 member 3 Transporter 1.3E-07 0.578 0.769 2
TREX1 Q9NSU2 three prime repair exonuclease 1 0.58 0.517 0.808 13
IFIH1 Q9BYX4 interferon induced with helicase C domain 1 7.0E-44 0.471 0.808 6
ADAR P55265 adenosine deaminase RNA specific Enzyme 2.6E-02 0.501 0.808 5
ADAM17 P78536 ADAM metallopeptidase domain 17 1.00 0.453 0.808 4