Source: GENOMICS_ENGLAND

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
IFIH1 Q9BYX4 interferon induced with helicase C domain 1 7.0E-44 0.471 0.808 6
NOD2 Q9HC29 nucleotide binding oligomerization domain containing 2 Enzyme 2.0E-30 0.423 0.923 4
NLRP12 P59046 NLR family pyrin domain containing 12 3.6E-28 0.569 0.846 2
CARD14 Q9BXL6 caspase recruitment domain family member 14 1.2E-19 0.546 0.846 6
NLRP1 Q9C000 NLR family pyrin domain containing 1 5.0E-19 0.502 0.769 2
MEFV O15553 MEFV innate immuity regulator, pyrin 1.0E-14 0.440 0.885 4
SAMHD1 Q9Y3Z3 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 6.5E-13 0.547 0.769 7
NLRC4 Q9NPP4 NLR family CARD domain containing 4 9.9E-12 0.556 0.769 3
SH3BP2 P78314 SH3 domain binding protein 2 1.2E-11 0.623 0.654 2
RNASEH2B Q5TBB1 ribonuclease H2 subunit B 3.3E-09 0.595 0.615 6
IL36RN Q9UBH0 interleukin 36 receptor antagonist 3.4E-08 0.638 0.538 3
ADA2 Q9NZK5 adenosine deaminase 2 Enzyme 8.1E-08 0.545 0.846 8
SLC29A3 Q9BZD2 solute carrier family 29 member 3 Transporter 1.3E-07 0.578 0.769 2
PSTPIP1 O43586 proline-serine-threonine phosphatase interacting protein 1 Cellular structure 2.5E-06 0.650 0.577 3
LPIN2 Q92539 lipin 2 5.0E-05 0.628 0.615 6
DNASE2 O00115 deoxyribonuclease 2, lysosomal Enzyme 4.5E-04 0.700 0.462 4
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 6
STING1 Q86WV6 stimulator of interferon response cGAMP interactor 1 1.2E-03 0.522 0.769 2
USP18 Q9UMW8 ubiquitin specific peptidase 18 1.5E-03 0.601 0.615 3
RNASEH2A O75792 ribonuclease H2 subunit A Enzyme 4.2E-03 0.592 0.692 5
RNASEH2C Q8TDP1 ribonuclease H2 subunit C 5.5E-03 0.590 0.731 5
AP1S3 Q96PC3 adaptor related protein complex 1 subunit sigma 3 Transporter 1.6E-02 0.711 0.385 2
PSMB8 P28062 proteasome 20S subunit beta 8 2.2E-02 0.533 0.808 3
ADAR P55265 adenosine deaminase RNA specific Enzyme 2.6E-02 0.501 0.808 5