Source: GENOMICS_ENGLAND

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 6
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 6
TNFRSF1A P19438 TNF receptor superfamily member 1A 0.99 0.409 0.923 3
NOD2 Q9HC29 nucleotide binding oligomerization domain containing 2 Enzyme 2.0E-30 0.423 0.923 4
MEFV O15553 MEFV innate immuity regulator, pyrin 1.0E-14 0.440 0.885 4
ADAM17 P78536 ADAM metallopeptidase domain 17 1.00 0.453 0.808 4
IFIH1 Q9BYX4 interferon induced with helicase C domain 1 7.0E-44 0.471 0.808 6
TNFAIP3 P21580 TNF alpha induced protein 3 Enzyme 1.00 0.481 0.808 3
ADAR P55265 adenosine deaminase RNA specific Enzyme 2.6E-02 0.501 0.808 5
NLRP1 Q9C000 NLR family pyrin domain containing 1 5.0E-19 0.502 0.769 2
TREX1 Q9NSU2 three prime repair exonuclease 1 0.58 0.517 0.808 13
STING1 Q86WV6 stimulator of interferon response cGAMP interactor 1 1.2E-03 0.522 0.769 2
PSMB8 P28062 proteasome 20S subunit beta 8 2.2E-02 0.533 0.808 3
ADA2 Q9NZK5 adenosine deaminase 2 Enzyme 8.1E-08 0.545 0.846 8
CARD14 Q9BXL6 caspase recruitment domain family member 14 1.2E-19 0.546 0.846 6
SAMHD1 Q9Y3Z3 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 6.5E-13 0.547 0.769 7
NLRC4 Q9NPP4 NLR family CARD domain containing 4 9.9E-12 0.556 0.769 3
ACP5 P13686 acid phosphatase 5, tartrate resistant 7.9E-02 0.561 0.731 3
NLRP12 P59046 NLR family pyrin domain containing 12 3.6E-28 0.569 0.846 2
MVK Q03426 mevalonate kinase Kinase 0.17 0.576 0.731 8
SLC29A3 Q9BZD2 solute carrier family 29 member 3 Transporter 1.3E-07 0.578 0.769 2
PLCG2 P16885 phospholipase C gamma 2 Enzyme 1.00 0.588 0.808 3
RNASEH2C Q8TDP1 ribonuclease H2 subunit C 5.5E-03 0.590 0.731 5
RNASEH2A O75792 ribonuclease H2 subunit A Enzyme 4.2E-03 0.592 0.692 5