Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 167 4
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 179 27
IFNG P01579 interferon gamma 0.47 0.288 0.962 167 1
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 141 11
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 138 9
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 109 1
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 109 7
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 119 12
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 80 3
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 48 35
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 89 2
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 101 18
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 69 3
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 68 172
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 115 30
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 119 20
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 42 22
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 241 7
TLR2 O60603 toll like receptor 2 1.0E-06 0.361 0.923 34 2