Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 187
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 95
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 337
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 255
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 209
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 147
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 132
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 125
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 119
INS P01308 insulin 0.30 0.445 0.923 73
LAMC2 Q13753 laminin subunit gamma 2 Enzyme modulator 2.9E-12 0.389 0.923 47
ABL1 P00519 ABL proto-oncogene 1, non-receptor tyrosine kinase Kinase 1.00 0.432 0.923 43
CASP8 Q14790 caspase 8 Enzyme 3.7E-06 0.404 0.923 19
LMNA P02545 lamin A/C 1.00 0.384 0.885 425
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 303
SDHD O14521 succinate dehydrogenase complex subunit D Transporter 0.34 0.472 0.885 212
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 205
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 176
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 0.68 0.420 0.885 169
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 154
PHGDH O43175 phosphoglycerate dehydrogenase Enzyme 1.3E-04 0.484 0.885 141
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 141
HDAC8 Q9BY41 histone deacetylase 8 Epigenetic regulator 0.98 0.511 0.885 137
CAV1 Q03135 caveolin 1 Enzyme modulator 8.3E-03 0.388 0.885 132