Source: ANIMAL_MODELS

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
ESR2 Q92731 estrogen receptor 2 Nuclear receptor 4.5E-08 0.400 0.923 25
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 25
TLR2 O60603 toll like receptor 2 1.0E-06 0.361 0.923 25
MMP3 P08254 matrix metallopeptidase 3 Enzyme 5.7E-15 0.408 0.885 24
NGF P01138 nerve growth factor Signaling 0.82 0.391 0.885 24
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 24
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923 23
NGFR P08138 nerve growth factor receptor Receptor 9.8E-02 0.477 0.846 23
NPY P01303 neuropeptide Y Signaling 0.14 0.447 0.846 22
ADM P35318 adrenomedullin Signaling 4.1E-02 0.436 0.808 21
AQP4 P55087 aquaporin 4 Ion channel 2.3E-03 0.456 0.885 21
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 21
IL6R P08887 interleukin 6 receptor Signaling 3.2E-05 0.471 0.846 20
GRIN2B Q13224 glutamate ionotropic receptor NMDA type subunit 2B Ion channel 1.00 0.510 0.692 19
PTGS1 P23219 prostaglandin-endoperoxide synthase 1 Enzyme 6.2E-07 0.460 0.885 19
DNMT1 P26358 DNA methyltransferase 1 Epigenetic regulator 1.00 0.406 0.885 18
AIF1 P55008 allograft inflammatory factor 1 Calcium-binding protein 1.9E-06 0.521 0.808 17
BDKRB2 P30411 bradykinin receptor B2 G-protein coupled receptor 0.12 0.585 0.808 17
HTR2A P28223 5-hydroxytryptamine receptor 2A G-protein coupled receptor 0.51 0.473 0.846 17
PTAFR P25105 platelet activating factor receptor G-protein coupled receptor 0.24 0.575 0.731 17
ABAT P80404 4-aminobutyrate aminotransferase Enzyme 6.3E-03 0.628 0.538 16
ADRB1 P08588 adrenoceptor beta 1 G-protein coupled receptor 2.9E-06 0.555 0.769 16
BDKRB1 P46663 bradykinin receptor B1 G-protein coupled receptor 4.7E-03 0.619 0.731 16
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 16