Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PDYN P01213 prodynorphin Signaling 1.7E-04 0.535 0.577 102 7
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 101 18
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 93 98
HTR1A P08908 5-hydroxytryptamine receptor 1A G-protein coupled receptor 0.20 0.522 0.846 93 1
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 92 30
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 89 2
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 89 1
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 87 79
GDNF P39905 glial cell derived neurotrophic factor Signaling 0.20 0.434 0.885 85 5
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 82 6
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 80 3
AVP P01185 arginine vasopressin Signaling 7.4E-02 0.437 0.846 78 18
TAC1 P20366 tachykinin precursor 1 0.75 0.424 0.923 77 0
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846 76 24
SLC6A4 P31645 solute carrier family 6 member 4 Transporter 0.25 0.429 0.808 75 6
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 69 3
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 68 172
POLG P54098 DNA polymerase gamma, catalytic subunit Enzyme 2.1E-09 0.457 0.846 68 157
CHRNA7 P36544 Q494W8 cholinergic receptor nicotinic alpha 7 subunit Ion channel 4.2E-04 0.532 0.654 68 12
DRD3 P35462 dopamine receptor D3 G-protein coupled receptor 2.4E-03 0.529 0.692 67 0
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923 61 1
SCN8A Q9UQD0 sodium voltage-gated channel alpha subunit 8 Ion channel 1.00 0.510 0.731 60 64
HTR2A P28223 5-hydroxytryptamine receptor 2A G-protein coupled receptor 0.51 0.473 0.846 60 1
SERPINA1 P01009 serpin family A member 1 Enzyme modulator 6.8E-08 0.410 0.923 59 47