Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 241 7
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 184 9
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 182 355
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 171 2
IFNG P01579 interferon gamma 0.47 0.288 0.962 167 1
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 141 11
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 120 21
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 119 20
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 119 12
LEP P41159 leptin 0.46 0.349 0.846 114 3
PON1 P27169 paraoxonase 1 9.8E-11 0.409 0.885 112 15
OXT P01178 oxytocin/neurophysin I prepropeptide Signaling 0.71 0.615 0.423 110 1
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 103 4
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 101 18
PRL P01236 prolactin Signaling 2.9E-07 0.406 0.885 97 0
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 95 596
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 95 5
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 92 30
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 90 362
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 90 28
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 82 6