Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 92
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 69
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 62
NOS1 P29475 nitric oxide synthase 1 1.00 0.408 0.885 44
BECN1 Q14457 beclin 1 Enzyme modulator 0.94 0.432 0.846 39
CASP9 P55211 caspase 9 Enzyme 7.4E-06 0.458 0.808 37
GSR P00390 glutathione-disulfide reductase Enzyme 1.3E-06 0.494 0.846 31
BAD Q92934 BCL2 associated agonist of cell death 4.6E-03 0.553 0.769 30
CX3CL1 P78423 C-X3-C motif chemokine ligand 1 Signaling 0.61 0.478 0.808 27
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 27
CX3CR1 P49238 C-X3-C motif chemokine receptor 1 G-protein coupled receptor 6.1E-02 0.457 0.885 26
RELA Q04206 RELA proto-oncogene, NF-kB subunit Transcription factor 1.00 0.406 0.885 26
MMP3 P08254 matrix metallopeptidase 3 Enzyme 5.7E-15 0.408 0.885 24
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846 23
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 21
CNR1 P21554 cannabinoid receptor 1 G-protein coupled receptor 0.51 0.446 0.808 19
TH P07101 tyrosine hydroxylase 1.7E-06 0.462 0.885 18
ABAT P80404 4-aminobutyrate aminotransferase Enzyme 6.3E-03 0.628 0.538 16
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923 16
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 15
SHH Q15465 sonic hedgehog signaling molecule 0.98 0.461 0.846 13
ABCC8 Q09428 ATP binding cassette subfamily C member 8 Transporter 8.0E-24 0.474 0.846 12
KCNJ11 Q14654 potassium inwardly rectifying channel subfamily J member 11 Ion channel 1.1E-02 0.529 0.615 9