Source: BEFREE

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2245 232
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1277 41
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 1105 16
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1.4E-06 0.320 0.885 1087 12
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 1077 12
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1011 29
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 942 62
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 935 11
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 805 39
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 747 8
GH1 P01241 growth hormone 1 Signaling 3.0E-02 0.373 0.923 652 15
EPHB2 P29323 EPH receptor B2 Kinase 1.00 0.374 0.846 636 9
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 627 41
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 563 65
CSF3 P09919 colony stimulating factor 3 0.38 0.377 0.885 552 2
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 546 5
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 525 37
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 514 45
HTC2 hypertrichosis 2 (generalized, congenital) 0.392 0.808 511 0
CD38 P28907 CD38 molecule Enzyme 2.3E-06 0.407 0.885 463 7
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 422 24
HLA-C P10321 major histocompatibility complex, class I, C 1.6E-06 0.415 0.846 409 25
AFP P02771 alpha fetoprotein Transporter 1.1E-11 0.429 0.885 374 6
DMD P11532 dystrophin 1.00 0.423 0.923 360 36