Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 56 3018
ERCC4 Q92889 ERCC excision repair 4, endonuclease catalytic subunit Enzyme 1.4E-12 0.468 0.846 41 15
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 33 395
FANCA O15360 FA complementation group A 1.6E-68 0.505 0.731 25 198
FANCC Q00597 FA complementation group C 2.8E-13 0.507 0.808 23 84
GATA1 P15976 GATA binding protein 1 0.95 0.483 0.808 22 18
TBX3 O15119 T-box transcription factor 3 Transcription factor 0.99 0.525 0.769 22 10
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731 21 227
RAD51C O43502 RAD51 paralog C 6.2E-14 0.533 0.692 19 90
FANCB Q8NB91 FA complementation group B 1.00 0.468 0.769 16 6
FANCG O15287 FA complementation group G 2.5E-14 0.556 0.769 15 18
SALL4 Q9UJQ4 spalt like transcription factor 4 Transcription factor 1.00 0.489 0.769 15 13
RPS19 P39019 ribosomal protein S19 Nucleic acid binding 0.92 0.480 0.846 14 15
FANCD2 Q9BXW9 FA complementation group D2 1.1E-30 0.479 0.885 12 13
FANCI Q9NVI1 FA complementation group I 8.9E-37 0.543 0.731 11 28
FANCF Q9NPI8 FA complementation group F 0.46 0.535 0.731 11 7
FANCE Q9HB96 FA complementation group E 1.5E-06 0.553 0.808 11 4
FANCL Q9NW38 FA complementation group L Enzyme 5.9E-23 0.551 0.731 10 14
SLX4 Q8IY92 SLX4 structure-specific endonuclease subunit 1.6E-22 0.565 0.731 10 12
SALL1 Q9NSC2 spalt like transcription factor 1 Transcription factor 1.00 0.539 0.808 9 16
FANCM Q8IYD8 FA complementation group M Enzyme 2.4E-15 0.543 0.731 9 11
TBX5 Q99593 T-box transcription factor 5 Transcription factor 1.00 0.528 0.769 8 81
RPL5 P46777 ribosomal protein L5 Nucleic acid binding 1.00 0.617 0.615 8 16
RPS26 P62854 ribosomal protein S26 Nucleic acid binding 0.85 0.716 0.538 8 11