Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.100 GeneticVariation LHGDN Genetic polymorphism of exon 5 of GSTP1 may be associated with COPD because the GSTP1/Ile105 genotype is predominantly found in COPD. 10413721

1999
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide. 11751372

2001
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0282612
Disease: Prostatic Intraepithelial Neoplasias
Prostatic Intraepithelial Neoplasias 		0.400 AlteredExpression LHGDN GSTA1 expression in normal, preneoplastic, and neoplastic human prostate tissue. 11550208

2001
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.100 AlteredExpression LHGDN Low levels of GSTA1 and GSTP1 in HGPIN and adenocarcinoma suggest a broad lack of detoxification activity in these cells, which may be associated with carcinogenesis in the prostate. 11550208

2001
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.080 AlteredExpression LHGDN [Value of P-glycoprotein and glutathione S-transferase-pi as chemo-resistant indicators in ovarian cancers]. 11783115

2001
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Genetic polymorphisms of glutathione S-transferases as modulators of lung cancer susceptibility. 12189190

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 Biomarker LHGDN Genetic determinants of lung cancer short-term survival: the role of glutathione-related genes. 11844594

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study. 12376472

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0004096
Disease: Asthma
Asthma 		0.400 Biomarker LHGDN These data suggest that homozygosity for the GSTP1*Val allele confers protection against TDI-induced asthma and airway hyperresponsiveness. 11994713

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 AlteredExpression LHGDN We report here that inhibition of transcription from hypermethylated GSTP1 promoters in Hep3B HCC cells, which fail to express GSTP1 mRNA or GSTP1 polypeptides, appears to be mediated by MBD2. 11960994

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.100 AlteredExpression LHGDN Expression of glutathione s-transferase pi in benign mucosa, Barrett's metaplasia, and adenocarcinoma of the esophagus. 12112555

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.100 GeneticVariation LHGDN Lack of association between glutathione S-transferase P1 polymorphism and COPD in Koreans. 12172904

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C1961102
Disease: Precursor Cell Lymphoblastic Leukemia Lymphoma
Precursor Cell Lymphoblastic Leukemia Lymphoma 		0.070 AlteredExpression LHGDN Glutathione S-transferase P1 genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukaemia. 12439226

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.060 GeneticVariation LHGDN Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer. 12072547

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.050 GeneticVariation LHGDN In conclusion, GSTP1-Ile(105)-encoding allele contributes to hepatic dysfunction in CF. 12297838

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.040 GeneticVariation LHGDN Among the youngest patients, aged 6 years, GSTP1-Ile(105)/Ile(105) genotype was associated with a 8-fold increase in the risk of liver disease compared with other GSTP1 genotypes (P =.002). 12297838

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.010 Biomarker LHGDN Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia. 12010828

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis 		0.010 AlteredExpression LHGDN Damaged interlobular bile ducts in primary biliary cirrhosis show reduced expression of glutathione-S-transferase-pi and aberrant expression of 4-hydroxynonenal. 12127421

2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Glutathione S-transferase M1 and P1 metabolic polymorphism and lung cancer predisposition. 14628089

2003
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 Biomarker LHGDN Smoking and the risk of lung cancer: susceptibility with GSTP1 polymorphisms. 14501269

2003
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 AlteredExpression LHGDN Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer. 12789263

2003
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression LHGDN Glutathione S-transferase pi is upregulated in the stromal compartment of hormone independent prostate cancer. 12746833

2003
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Glutathion S transferase pi indicates chemotherapy resistance in breast cancer. 12943817

2003
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 PosttranslationalModification LHGDN Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells. 12543808

2003
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 Biomarker LHGDN Immunohistochemical expression of pi class glutathione S-transferase and alpha-fetoprotein in hepatocellular carcinoma and chronic liver disease. 14714299

2003