×
Entrez Id: 639
Gene Symbol: PRDM1
PRDM1
Lupus Erythematosus, Systemic
0.550
Biomarker
MGD
×
Entrez Id: 9474
Gene Symbol: ATG5
ATG5
Lupus Erythematosus, Systemic
0.390
Biomarker
MGD
×
Entrez Id: 51284
Gene Symbol: TLR7
TLR7
Lupus Erythematosus, Systemic
0.300
Biomarker
MGD
×
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
Lupus Erythematosus, Systemic
0.300
Biomarker
MGD
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Lupus Erythematosus, Systemic
0.230
Biomarker
MGD
×
Entrez Id: 3726
Gene Symbol: JUNB
JUNB
Lupus Erythematosus, Systemic
0.230
Biomarker
MGD
×
Entrez Id: 8678
Gene Symbol: BECN1
BECN1
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
×
Entrez Id: 3635
Gene Symbol: INPP5D
INPP5D
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
×
Entrez Id: 10533
Gene Symbol: ATG7
ATG7
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
×
Entrez Id: 2033
Gene Symbol: EP300
EP300
Lupus Erythematosus, Systemic
0.200
Biomarker
MGD
×
Entrez Id: 6256
Gene Symbol: RXRA
RXRA
Lupus Erythematosus, Systemic
0.200
Biomarker
MGD
×
Entrez Id: 1647
Gene Symbol: GADD45A
GADD45A
Lupus Erythematosus, Systemic
0.220
Biomarker
MGD
Gadd45a (-/-) mice develop an autoimmune disease, similar to human systemic lupus erythematosus (SLE ), characterized by high titers of anti-dsDNA, anti-ssDNA, and anti-histone autoantibodies, severe hematological disorders, autoimmune glomerulonephritis, and premature death.11970874 2002
×
Entrez Id: 83593
Gene Symbol: RASSF5
RASSF5
Lupus Erythematosus, Systemic
0.200
Biomarker
MGD
RAPL -deficient mice experienced age-related lupus -like glomerulonephritis and developed B cell lymphomas.21194982 2011
×
Entrez Id: 122618
Gene Symbol: PLD4
PLD4
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
Pld4 mutant mice revealed autoimmune phenotypes suggesting functional involvement of PLD4 with the basics of SLE .30679154 2019
×
Entrez Id: 6738
Gene Symbol: RO60
RO60
Lupus Erythematosus, Systemic
0.300
Biomarker
MGD
A lupus -like syndrome develops in mice lacking the Ro 60 -kDa protein, a major lupus autoantigen.
12788971 2003
×
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
Lupus Erythematosus, Systemic
0.900
Biomarker
MGD
A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice.
21159799 2011
×
Entrez Id: 149041
Gene Symbol: RC3H1
RC3H1
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.
15917799 2005
TNFRSF13B
Lupus Erythematosus, Systemic
0.280
Biomarker
MGD
Activation and accumulation of B cells in TACI-deficient mice.
11429549 2001
×
Entrez Id: 22806
Gene Symbol: IKZF3
IKZF3
Lupus Erythematosus, Systemic
0.330
Biomarker
MGD
Aiolos regulates B cell activation and maturation to effector state.
9806640 1998
×
Entrez Id: 4124
Gene Symbol: MAN2A1
MAN2A1
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis.
9230311 1997
×
Entrez Id: 5788
Gene Symbol: PTPRC
PTPRC
Lupus Erythematosus, Systemic
0.240
Biomarker
MGD
An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity.
11163182 2000
×
Entrez Id: 355
Gene Symbol: FAS
FAS
Lupus Erythematosus, Systemic
0.400
Biomarker
MGD
Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern.
12486097 2002
×
Entrez Id: 10125
Gene Symbol: RASGRP1
RASGRP1
Lupus Erythematosus, Systemic
0.620
Biomarker
MGD
Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.
12932358 2003
×
Entrez Id: 4067
Gene Symbol: LYN
LYN
Lupus Erythematosus, Systemic
0.320
Biomarker
MGD
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
20512127 2010
×
Entrez Id: 3930
Gene Symbol: LBR
LBR
Lupus Erythematosus, Systemic
0.220
Biomarker
MGD
Because granulocytes isolated from human SLE patients had alterations in neutrophil nuclear morphology that resembled the Pelger-Huet anomaly, and had prominent mis-splicing of mRNA encoding the nuclear membrane protein lamin B receptor (LBR ), consistent with their Pelger-Huet-like nuclear morphology, we used a novel mouse model system to test the hypothesis that a disruption in the structure of the nucleus itself also contributes to the development of lupus autoimmunity.
27483354 2016