Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9474
Gene Symbol: ATG5
ATG5
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.390 Biomarker MGD

Entrez Id: 10533
Gene Symbol: ATG7
ATG7
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.210 Biomarker MGD

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.210 Biomarker MGD

Entrez Id: 712
Gene Symbol: C1QA
C1QA
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.670 Biomarker MGD Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice. 12794146

2003
Entrez Id: 712
Gene Symbol: C1QA
C1QA
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.670 Biomarker MGD Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. 9590289

1998
Entrez Id: 720
Gene Symbol: C4A
C4A
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.700 Biomarker MGD Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 11067882

2000
Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.600 Biomarker MGD Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 11067882

2000
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.300 Biomarker MGD

Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.240 Biomarker MGD Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals. 17848507

2007
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.240 Biomarker MGD Genomic instability in Gadd45a-deficient mice. 10508513

1999
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.240 Biomarker MGD Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. 11970874

2002
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.260 Biomarker MGD Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells. 27096368

2016
Entrez Id: 50619
Gene Symbol: DEF6
DEF6
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.520 Biomarker MGD Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity. 16470246

2006
Entrez Id: 1773
Gene Symbol: DNASE1
DNASE1
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.900 Biomarker MGD Our findings suggest that lack or reduction of Dnase1 is a critical factor in the initiation of human SLE. 10835632

2000
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.200 Biomarker MGD

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.400 Biomarker MGD Comparative influence of steroid hormones and immunosuppressive agents on autoimmune expression in lacrimal glands of a female mouse model of Sjögren's syndrome. 8163351

1994
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.400 Biomarker MGD Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. 6610701

1984
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.400 Biomarker MGD Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. 309911

1978
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.400 Biomarker MGD Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene. 6975351

1981
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.400 Biomarker MGD Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. 12486097

2002
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.400 Biomarker MGD Transfer of Sjögren's syndrome-like autoimmune lesions into SCID mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment. 7957574

1994
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.400 Biomarker MGD Reduced cell-cell communication in a spontaneous murine model of autoimmune thyroid disease. 7628400

1995
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.400 Biomarker MGD Splenic immunoglobulin-secreting cells and their regulation in autoimmune mice. 6444324

1980
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.400 Biomarker MGD Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice. 3009614

1986
Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.400 Biomarker MGD Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes. 762500

1979