Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 56729
Gene Symbol: RETN
RETN
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD A novel non-alcoholic steatohepatitis animal model featured with insulin resistance, hepatic inflammation and fibrosis. 20560816

2010
Entrez Id: 51548
Gene Symbol: SIRT6
SIRT6
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. 21373642

2011
Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. 21373642

2011
Entrez Id: 64240
Gene Symbol: ABCG5
ABCG5
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 ModifyingMutation RGD An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training. 23117815

2013
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 ModifyingMutation RGD An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training. 23117815

2013
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 ModifyingMutation RGD An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training. 23117815

2013
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 ModifyingMutation RGD An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training. 23117815

2013
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. 19913842

2010
Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats. 26576191

2015
Entrez Id: 23409
Gene Symbol: SIRT4
SIRT4
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats. 20651844

2010
Entrez Id: 5599
Gene Symbol: MAPK8
MAPK8
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Celecoxib ameliorates non-alcoholic steatohepatitis in type 2 diabetic rats via suppression of the non-canonical Wnt signaling pathway expression. 24404139

2014
Entrez Id: 84649
Gene Symbol: DGAT2
DGAT2
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Clostridium butyricum MIYAIRI 588 improves high-fat diet-induced non-alcoholic fatty liver disease in rats. 24166662

2013
Entrez Id: 2936
Gene Symbol: GSR
GSR
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Comparative effect of pioglitazone, quercetin and hydroxy citric acid on the status of lipid peroxidation and antioxidants in experimental non-alcoholic steatohepatitis. 24622831

2014
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis. 23301938

2013
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Curative effect of arjunolic acid from Terminalia arjuna in non-alcoholic fatty liver disease models. 30257410

2018
Entrez Id: 2539
Gene Symbol: G6PD
G6PD
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling. 20211032

2010
Entrez Id: 3240
Gene Symbol: HP
HP
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein. 21806828

2011
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats. 21359922

2011
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Effects of salvianolic acid B on liver mitochondria of rats with nonalcoholic steatohepatitis. 26401075

2015
Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats. 30186875

2018
Entrez Id: 498
Gene Symbol: ATP5F1A
ATP5F1A
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD Exposure to a northern contaminant mixture (NCM) alters hepatic energy and lipid metabolism exacerbating hepatic steatosis in obese JCR rats. 25222487

2014
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD. 24351808

2013
Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD Hepcidin levels correlate to liver iron content, but not steatohepatitis, in non-alcoholic fatty liver disease. 29871592

2018
Entrez Id: 7037
Gene Symbol: TFRC
TFRC
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD High Fat Diet Induces Liver Steatosis and Early Dysregulation of Iron Metabolism in Rats. 23805238

2013
Entrez Id: 48
Gene Symbol: ACO1
ACO1
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD High Fat Diet Induces Liver Steatosis and Early Dysregulation of Iron Metabolism in Rats. 23805238

2013