Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Identification of chemerin as a novel FXR target gene down-regulated in the progression of nonalcoholic steatohepatitis. 23507574

2013

Entrez Id: 348
Gene Symbol: APOE
APOE
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats. 21184788

2011

Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? 25263431

2014

Entrez Id: 27141
Gene Symbol: CIDEB
CIDEB
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? 25263431

2014

Entrez Id: 1582
Gene Symbol: CYP8B1
CYP8B1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? 25263431

2014

Entrez Id: 10062
Gene Symbol: NR1H3
NR1H3
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? 25263431

2014

Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? 25263431

2014

Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? 25263431

2014

Entrez Id: 64240
Gene Symbol: ABCG5
ABCG5
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? 25263431

2014

Entrez Id: 7351
Gene Symbol: UCP2
UCP2
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Increased hepatic UCP2 expression in rats with nonalcoholic steatohepatitis is associated with upregulation of Sp1 binding to its motif within the proximal promoter region. 18543254

2008

Entrez Id: 11093
Gene Symbol: ADAMTS13
ADAMTS13
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis. 19652891

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Innate immune reactivity of the liver in rats fed a choline-deficient L-amino-acid-defined diet. 19034968

2008

Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Therapeutic RGD Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. 17241878

2007

Entrez Id: 3643
Gene Symbol: INSR
INSR
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 SusceptibilityMutation RGD Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease. 28468951

2017

Entrez Id: 5264
Gene Symbol: PHYH
PHYH
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Therapeutic RGD Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics for the investigation of the effect of Hugan Qingzhi on non-alcoholic fatty liver disease in rats. 29031784

2018

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Kupffer cell depletion protects against the steatosis, but not the liver damage, induced by marginal-copper, high-fructose diet in male rats. 25813056

2015

Entrez Id: 22933
Gene Symbol: SIRT2
SIRT2
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Therapeutic RGD Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. 22327056

2012

Entrez Id: 23410
Gene Symbol: SIRT3
SIRT3
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Therapeutic RGD Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. 22327056

2012

Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. 22112382

2012

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Biomarker RGD Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. 22112382

2012

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Therapeutic RGD Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. 23592516

2013

Entrez Id: 5445
Gene Symbol: PON2
PON2
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Therapeutic RGD Paraoxonase activity and expression is modulated by therapeutics in experimental rat nonalcoholic Fatty liver disease. 22536512

2012

Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 Therapeutic RGD Pioglitazone, quercetin and hydroxy citric acid effect on cytochrome P450 2E1 (CYP2E1) enzyme levels in experimentally induced non alcoholic steatohepatitis (NASH). 25317811

2014

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 SusceptibilityMutation RGD Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. 24275070

2014

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
0.200 SusceptibilityMutation RGD Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. 24275070

2014