Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.700 AlteredExpression LHGDN Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. 15802268

2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma 		0.700 AlteredExpression LHGDN Regulation of c-Met-dependent gene expression by PTEN. 15516982

2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.700 PosttranslationalModification LHGDN RRM1-induced metastasis suppression through PTEN-regulated pathways. 12687015

2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.700 AlteredExpression LHGDN Expression of PTEN in 40 cases of renal cell carcinoma were different, 12.5% were negative, 17.5% were weak positive, and 70% were strong positive. 12452054

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma 		0.700 GeneticVariation LHGDN Since then, important progress has been made with respect to the understanding of the role of the Pten protein in the normal development of the brain as well as in the molecular pathogenesis of human gliomas. 12084351

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0085261
Disease: Proteus Syndrome
Proteus Syndrome 		0.700 GeneticVariation LHGDN PTEN mutations are uncommon in Proteus syndrome. 11476065

2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. 19116269

2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 AlteredExpression LHGDN PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinoma. 18632658

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 AlteredExpression LHGDN The expression of mammalian target of rapamycin in Ishikawa and HEC-1A cells. 18563337

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 AlteredExpression LHGDN Correlation between NDRG1 and PTEN expression in endometrial carcinoma. 18377423

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN [Role of PTEN protein in multidrug resistance of prostate cancer cells]. 18702307

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN Is PTEN loss associated with clinical outcome measures in human prostate cancer? 18854827

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 GeneticVariation LHGDN Molecular genetic defects in endometrial carcinomas: microsatellite instability, PTEN and beta-catenin (CTNNB1) genes mutations. 17219201

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 Biomarker LHGDN Imprint smears were obtained from 80 fresh endometrial tumor specimens and studied immunocytochemically for the expression of PTEN, p53, and beta-catenin proteins. 17504383

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 AlteredExpression LHGDN Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss. 17924977

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 PosttranslationalModification LHGDN Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. 17606718

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN The role of PTEN in prostate cancer cell tropism to the bone micro-environment. 17347137

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer. 17372210

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN Pten inactivation and the emergence of androgen-independent prostate cancer. 17638861

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. 17616684

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.600 AlteredExpression LHGDN The aberrant location of expression and staining intensity of PTEN, PPM1A and P-Smad2 in HCC and their relationship might have an impact on the pathogenesis of HCC. 17729405

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.600 Biomarker LHGDN PTEN down-regulation or p53 (+) correlated with increased HCC dedifferentiation, advanced pathologic stages and high PCNA labeling index (LI) of tumors (P<0.05). 17982625

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.600 AlteredExpression LHGDN Aberrant expression of miR-21 can contribute to HCC growth and spread by modulating PTEN expression and PTEN-dependent pathways involved in mediating phenotypic characteristics of cancer cells such as cell growth, migration, and invasion. 17681183

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 AlteredExpression LHGDN PIK3CA gene mutations in endometrial carcinoma: correlation with PTEN and K-RAS alterations. 16949921

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. 16697957

2006