Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. 16432235

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN Expression of mTOR signaling pathway markers in prostate cancer progression. 16652388

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN Significantly reduced PTEN expression was observed in AI versus benign and hormone naïve prostate tumors. 16496415

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 AlteredExpression LHGDN PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma. 16012720

2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN Metastatic properties of prostate cancer cells are controlled by VEGF. 15500293

2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis. 15897909

2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 GeneticVariation LHGDN The coexistence of ERBB2, INT2, and CMYC oncogene amplifications and PTEN gene mutations in endometrial carcinoma. 14663583

2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 AlteredExpression LHGDN Enhanced cell growth inhibition following PTEN nonviral gene transfer using polyethylenimine and photochemical internalization in endometrial cancer cells. 15453811

2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 GeneticVariation LHGDN PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas. 15492994

2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells. 15205473

2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.600 AlteredExpression LHGDN Our data suggest that PTEN blocks Sp1 phosphorylation in response to HBx, by inactivating PKC, MAPK and MAPK kinase which eventually downregulate IGF-II expression, during the formation of HCC. 12804776

2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.600 Biomarker LHGDN Lymph node metastases were present in 80% (12 out of 15) PTEN negative HCC, 57.14% (12 out of 21) PTEN weak positive HCC and only 10.71% (9 out of 84) PTEN intense positive HCC, (P<0.05). 12767263

2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 GeneticVariation LHGDN Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors. 11854177

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 GeneticVariation LHGDN Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinomas and hyperplasias. 11849740

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 AlteredExpression LHGDN PTEN expression is associated with prognosis for patients with advanced endometrial carcinoma undergoing postoperative chemotherapy. 12209607

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli. 12190124

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival. 12429629

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer. 12168088

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.500 Biomarker LHGDN Combining PTEN restoration to PTEN-null glioblastoma cells with c-Met and HGF inhibition additively inhibited tumor cell proliferation and cell cycle progression. 19190120

2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.500 Biomarker LHGDN These data suggest that loss of PTEN function is insufficient to adequately predict responsiveness to mTOR inhibitors in glioblastoma multiforme. 18559622

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 AlteredExpression LHGDN Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. 18066063

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors. 18332865

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.500 GeneticVariation LHGDN FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. 18787170

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.500 GeneticVariation LHGDN Screening of PTEN mutations is warranted in patients with autism and pronounced macrocephaly, even in the absence of other features of PTEN-related tumor syndromes. 17427195

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.500 Biomarker LHGDN PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors. 17255257

2007