Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 598
Gene Symbol: BCL2L1
BCL2L1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins. 20037173

2010

Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Therapeutic RGD Mannitol attenuates kidney damage induced by xanthine oxidase-associated pancreas ischemia-reperfusion. 19628223

2010

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins. 20037173

2010

Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Post-treatment effects of erythropoietin and nordihydroguaiaretic acid on recovery from cisplatin-induced acute renal failure in the rat. 19194548

2009

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Renal beta(2)-adrenoceptor modulates the lipopolysaccharide transport system in sepsis-induced acute renal failure. 19020966

2009

Entrez Id: 112399
Gene Symbol: EGLN3
EGLN3
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. 19349364

2009

Entrez Id: 210
Gene Symbol: ALAD
ALAD
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Diphenyl diselenide protects against glycerol-induced renal damage in rats. 19484701

2009

Entrez Id: 5925
Gene Symbol: RB1
RB1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Acute renal failure during sepsis: potential role of cell cycle regulation. 19428114

2009

Entrez Id: 54583
Gene Symbol: EGLN1
EGLN1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD In rat models of acute renal injury, changes in PHD expression levels were variable; while cisplatin and ischemia/reperfusion led to significant decreases in PHD2 and 3 expression levels, no changes were seen in a model of contrast media-induced nephropathy. 19349364

2009

Entrez Id: 6582
Gene Symbol: SLC22A2
SLC22A2
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Regulation of renal organic ion transporters in cisplatin-induced acute kidney injury and uremia in rats. 18612803

2008

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD The observed increase in HIF-1alpha protein expression, decrease in VEGF protein expression, and imbalance of vasoactive substances after induction of acute kidney injury by AA suggests that ischemic injury contributes to the pathogenesis of AAN. 18593636

2008

Entrez Id: 7356
Gene Symbol: SCGB1A1
SCGB1A1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Modulation of aquaporin-2/vasopressin2 receptor kidney expression and tubular injury after endotoxin (lipopolysaccharide) challenge. 18824919

2008

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Attenuation of glycerol-induced acute kidney injury by previous partial hepatectomy: role of hepatocyte growth factor/c-met axis in tubular protection. 17940345

2007

Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure. 16557226

2006

Entrez Id: 552
Gene Symbol: AVPR1A
AVPR1A
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Early, but not late therapy with a vasopressin V1a-antagonist ameliorates the development of renal damage after 5/6 nephrectomy. 17347933

2006

Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Therapeutic RGD Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. 16762988

2006

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Therapeutic RGD Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. 16762988

2006

Entrez Id: 5734
Gene Symbol: PTGER4
PTGER4
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Therapeutic RGD Role of EP2 and EP4 receptor-selective agonists of prostaglandin E(2) in acute and chronic kidney failure. 16871242

2006

Entrez Id: 834
Gene Symbol: CASP1
CASP1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure. 16557226

2006

Entrez Id: 2243
Gene Symbol: FGA
FGA
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers. 15805072

2005

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxia. 15673301

2005

Entrez Id: 2837
Gene Symbol: UTS2R
UTS2R
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System. 15146030

2004

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD beta(2)-Adrenoceptor activation attenuates endotoxin-induced acute renal failure. 14747378

2004

Entrez Id: 3312
Gene Symbol: HSPA8
HSPA8
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD 73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin. 14966137

2004

Entrez Id: 1649
Gene Symbol: DDIT3
DDIT3
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD The induction of cell cycle regulatory and DNA repair proteins in cisplatin-induced acute renal failure. 15476864

2004