|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
NS1 proteins of influenza A and B viruses share limited sequence homology, yet both are potent manipulators of host cell processes, particularly interferon (IFN) induction.
|
28869005 |
2017 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Rational characterization of virulence and host-adaptive markers in the multifunctional influenza A virus NS1 protein is hindered by a lack of comprehensive knowledge about NS1-host protein protein interfaces.
|
28814525 |
2017 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
The NS1 protein from all strains of influenza A virus binds TRIM25, although not all virus strains block the interferon response, suggesting alternative mechanisms for TRIM25 action.
|
29107643 |
2017 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
It is known that the influenza A virus NS1 protein (NS1-A) interacts with RIG-I and TRIM25 to suppress the activation of RIG-I-mediated signaling.
|
27122586 |
2016 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Since hemagglutinin (HA) and non-structural 1 (NS1) proteins are relevant in respect of adaptive and innate immune responses, the present study was aimed at establishing the intra-host genetic heterogeneity of HA and NS1 genes, applying ultra-deep pyrosequencing (UDPS) to nasopharyngeal swabs (NPS) from patients with confirmed influenza A(H1N1)pdm09 infection.
|
27186639 |
2016 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
The NS1 gene from bat-derived influenza-like virus H17N10 can be rescued in influenza A PR8 backbone.
|
27217257 |
2016 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
In contrast to the well-studied NS1 protein of influenza A virus, knowledge about structure and functions of the influenza B virus homologue B/NS1, which shares less than 25 % sequence identity, is still limited.
|
27654951 |
2016 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
In addition, intranasal instillation of AAV8-3xIRF-ISRE-Luc showed a rapid and transient IFN-I response in the respiratory tract of mice infected with the influenza A/PR8/34 virus lacking the NS1 protein.
|
27007218 |
2016 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
We analyzed the cellular localization and function of the N-truncated NS1 proteins encoded by two influenza A virus strains, Udorn/72/H3N2 (Ud) and Puerto Rico/8/34/H1N1 (PR8).
|
26912617 |
2016 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
These influenza A viruses encode mCherry fused to the viral non-structural 1 (NS1) protein and display comparable growth kinetics to wild-type viruses in vitro.
|
25553516 |
2015 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Characterization of a novel mutation in NS1 protein of influenza A virus induced by a chemical substance for the attenuation of pathogenicity.
|
25793397 |
2015 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.
|
25934792 |
2015 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
When compared to influenza A virus NS1 protein, EBOV VP35 showed improved inhibition of viral dsRNA-based IFN-β induction.
|
25926684 |
2015 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Functions of the influenza A virus NS1 protein in antiviral defense.
|
25638592 |
2015 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Influenza A virus genomic segments eight codes for non-structural 1 (NS1) protein that is involved in evasion of innate antiviral response, and nuclear export protein (NEP) that participates in the export of viral ribonucleoprotein (RNP) complexes, transcription and replication.
|
24657783 |
2014 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Routine surveillance specimens obtained from 70 patients with pH1N1 infection were evaluated for mutations associated with increased virulence (PB1-F2, PB2 and NS1 genes) or antiviral resistance (neuraminidase gene, NA) using MSCSA and Sanger sequencing.
|
24699508 |
2014 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
The influenza A virus NS1 protein is a virulence factor and an antagonist of host cell innate immune responses.
|
25023993 |
2014 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Conclusively, subtype-specific sequence variations in the IAV NS1 protein result in subtype-specific differences in JNK signaling upon IAV infection.
|
24872593 |
2014 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Influenza A viruses circulating in humans from ∼1950 to ∼1987 featured a nonstructural (NS1) protein with a C-terminal extension of seven amino acids.
|
23926347 |
2013 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Synergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus.
|
23408626 |
2013 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30.
|
23886034 |
2013 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Strains of the 2009 H1N1 pandemic influenza A virus could be divided into two categories based on the V123I mutation in the NS1 gene: G1 (characterized as 123 Val) and G2 (characterized as 123 Ile).
|
23418535 |
2013 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
The NS1 protein of influenza A virus is known to downregulate apoptosis early in infection in order to support virus replication (O. P. Zhirnov, T. E. Konakova, T. Wolff, and H. D. Klenk, J. Virol.76:1617-1625, 2002).
|
24027311 |
2013 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein.
|
21918006 |
2012 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.
|
23209422 |
2012 |