Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE This retrospective analysis included 45 subjects with COPD who were evaluated in a newly established dyspnea clinic over 3 years. 31719189

2020

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 GeneticVariation BEFREE These patients were noted to be younger (59 versus 61 years, p < 0.001) and less likely to have insulin-dependent diabetes (3.0 versus 4.4%, p < 0.001), preoperative dyspnea (2.2 versus 6.0%, p < 0.001), COPD (3.0 versus 4.2%, p = 0.011), and hypertension (40.7 versus 46.9%, p < 0.001) than patients who stayed longer. 31686161

2020

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE In recent years, multiorgan clinical ultrasonography (pulmonary, cardiac and vascular) has emerged as a tool of considerable usefulness in managing patients with COPD in numerous situations, including the differential diagnosis of dyspnoea of uncertain origin, the assessment of the aetiology in episodes of exacerbation, detecting concomitant heart failure or associated pulmonary hypertension and as support in managing cardiovascular risk factors such as subclinical atherosclerosis. 31447107

2020

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 GeneticVariation BEFREE The following associations emerged among respiratory symptom/disease cumulative incidence and risk factor exposure changes: a two-to-five fold higher risk for COPD, phlegm, cough, dyspnoea, asthma attacks, airway obstruction in persistent smokers; a two-to-three fold higher risk for COPD in remittent smokers; a two-fold higher risk for AR, phlegm and a four-fold higher risk for asthma in subjects with persistent occupational exposure; a two-fold higher risk for cough, phlegm, dyspnoea, AR in subjects with incident occupational exposure; a two-fold higher risk for AR, asthma attacks, COPD in subjects with incident traffic exposure. 31585374

2020

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE VitaBreath is a portable, non-invasive ventilation device (pNIV) that relieves shortness of breath in COPD by delivering fixed inspiratory and expiratory positive airway pressures (IPAP/EPAP: 18/8 cmH<sub>2</sub>O). 31271841

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE Other significant improvements with IND/MF (QMF 149) vs Sal/Flu were noted for dyspnea at week 12 and other COPD symptoms and COPD rescue medication use over the 12 weeks. 30584293

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE The BODE score (incorporating body mass index, airflow obstruction, dyspnea and exercise capacity) is used for the timing of listing for lung transplantation (LTx) in COPD, based on survival data from the original BODE cohort. 30573956

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE One hundred and thirty-three patients with COPD were assessed at baseline by spirometry, pulse oximetry (SpO<sub>2</sub>), body composition, intensity of dyspnea, distance walked in the 6-minute walk test (6MWT), and Charlson Comorbidity Index (CCI). 30410324

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE Comparison between COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) dyspnea scores for evaluation of clinical symptoms, comorbidities and medical resources utilization in COPD patients. 30150099

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE Accordingly, DB is often underdiagnosed or misdiagnosed, given the similarity of its associated symptoms (dyspnea, tachycardia, and dizziness) to those of other common cardiopulmonary diseases such as COPD and asthma. 30758427

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE The tolerability of the device for subjects with COPD appeared to be only slightly hampered by an increased sense of dyspnea attributed to wearing a mask. 30584067

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE Increased age trended toward readmission in ALIF/LLIF (P = 0.003); increased white cell count (P = 0.003), dyspnea (P = 0.030), and COPD (P = 0.005) trended in PLIF/TLIF. 30138253

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 GeneticVariation BEFREE We aimed to investigate whether subjects with COPD showing significant resting tidal F-V enveloping (ie, > 50% tidal volume) would present with higher exertional operating lung volumes, which would lead to greater burden of dyspnea and poorer exercise tolerance compared to their counterparts. 31455685

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE The GOLD system and the body mass index, obstruction, dyspnea and exercise (BODE) index were used for COPD classification. 30880950

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 AlteredExpression BEFREE Improvements in St George's Respiratory Questionnaire and transition dyspnea index were significantly greater than placebo in both current and ex-smokers, whereas changes in COPD assessment test were significant only among current smokers. 31344660

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE The prevalence of COPD is high among smokers and ex-smokers with one or more respiratory symptoms seen in primary care, and the presence of wheeze, phlegm and dyspnea, together with both low BMI and obesity identify a subgroup with an even higher likelihood of COPD. 31413558

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE Influence of comorbid heart disease on dyspnea and health status in patients with COPD - a cohort study. 30568437

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE Pulmonary rehabilitation (PR) improves exercise capacity, health-related quality of life (HRQoL) and dyspnoea in patients with COPD and other lung conditions. 30891887

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE The Portuguese version of the MDP is the first valid and reliable instrument to assess dyspnea multidimensionally in Portuguese-speaking patients with COPD. 31039167

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 GeneticVariation BEFREE We analyzed the association of dyspnea severity, quality of life status, and lung function with lung function measurements and exacerbation risk in 982 patients enrolled in the Korea COPD Subgroup Registry and Subtype Research study. 30787605

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE Here, we review the physiological and psychological consequences of activity-related dyspnea in COPD, assess the efficacy of modern management strategies in improving this common respiratory symptom, and discuss key unmet clinical and research needs that warrant further immediate attention. 31213793

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE However, older women remained more likely to experience severe dyspnea and to manifest more severe COPD (B vs A) than older men, despite lower pack-years of smoking. 30319250

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE Patients were classified according to COPD severity (1) in GOLD 2016 "ABCD" categories based on symptoms (Medical Research Council dyspnea grade, COPD Assessment Test, breathlessness), percent predicted FEV1, and exacerbation history and (2) as mild, moderate, severe, or very severe based on treatment and exacerbation history. 29740896

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE The aim of our study was to evaluate the relationship between the degree of dyspnea and exercise capacity in subjects with COPD who had the same severity of air-flow obstruction. 30425167

2019

Entrez Id: 260431
Gene Symbol: COPD
COPD
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.100 Biomarker BEFREE Extreme desert dust storm episodes may cause meaningful increases in ED visits for dyspnea and COPD exacerbations/admissions. 31496675

2019