Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We compared genotype frequencies in subjects with type 2 diabetes with those with NGT and found marginal association for rs7901695 (P = 0.05; odds ratio [OR] 1.51); comparison between NGT control subjects and the combined type 2 diabetes/IGT case group showed strong association with rs7901695 and rs7903146 (P = 0.008-0.01; OR 1.53-1.57) and marginal association with rs11196205 and rs12255372 (P = 0.07 and P = 0.04, respectively). 16936218

2006

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Both the T-allele of rs7903146 and the T-allele of rs12255372 significantly increase type 2 diabetes risk with an allelic odds ratio (OR) of 1.69 (95% CI 1.55-1.83) (P = 6.0 x 10(-35)) and 1.60 (1.47-1.74) (P = 7.6 x 10(-28)), respectively. 17003360

2006

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Three common variants (Lys23 of KCNJ11, Pro12 of PPARG, and the T allele at rs7903146 of TCF7L2) have been shown to predispose to type 2 diabetes mellitus across many large studies. 17020404

2006

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Recently, case-control studies demonstrated that a TCF7L2 (transcription factor 7-like 2 gene) noncoding variant (rs7903146 T at-risk allele) was strongly associated with an increased risk of type 2 diabetes. 17065361

2006

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Recently, the transcription factor 7-like 2 (TCF7L2) gene on chromosome 10q25.2 has been linked with type 2 diabetes among Caucasians, with disease associations noted for single nucleotide polymorphisms (SNPs) rs12255372 and rs7903146. 17130514

2006

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Results of our analyses strongly confirmed the minor T alleles as risk variants for type 2 diabetes (rs7903146: OR (TvsC) [95% CI]=1.36 [1.18;1.58], p=0.00003, and rs12255372: OR (TvsG) [95% CI]=1.31 [1.13;1.51], p=0.0003). 17226113

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The consistent association between rs7903146 in TCF7L2 and type 2 diabetes in different ethnic groups, including the Japanese population, suggests that TCF7L2 is a common susceptibility gene for type 2 diabetes. 17245589

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE A gene dosage effect of the rare allele of both variants was observed, the heterozygote CT group of rs7903146 having an odds ratio of 1.36 (95% CI 1.2-1.5, p=1.54 x 10(-7)) for type 2 diabetes and the TT homozygote having a greater risk (OR = 2.03, 95% CI 1.7-2.5, p=1.40 x 10(-12)). 17429603

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The SNP rs7903146 shows similar trends, but its association with T2D is not as strong (OR = 1.39, p = 0.152). 17470138

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We found 28 original published association studies dealing with the TCF7L2 rs7903146 polymorphism in T2D. 17476472

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The previously reported SNPs rs7903146 T- and rs12255372 T-alleles of the TCF7L2 gene were rare and were not associated with type 2 diabetes in a Chinese population, which may attribute to the low frequencies of these two SNPs. 17579206

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been also associated with a lower body mass index (BMI) in T2D individuals and with a smaller waist circumference in subjects with impaired glucose tolerance. 17593304

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Rs11196205 was associated with T2D [odds ratio (OR) [95% confidence interval (CI)] = 2.11 (1.04-4.26)], whereas the association for rs7903146 [OR (95% CI) = 1.27 (0.71-2.29)] was not significant in the case-control sample. 17609304

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In a population-based cohort of elderly men with well-defined phenotypes and biochemical markers related to type 2 diabetes mellitus, we analysed two single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, in the transcription factor 7-like 2 gene (TCF7L2), which are associated with an increased risk of type 2 diabetes mellitus. 17618413

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The CT/TT genotypes of SNP rs7903146 strongly predicted future T2D in 2 independent cohorts (Swedish and Finnish). 17671651

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In conclusion, the T allele of the rs12255372(G/T) and rs7903146(C/T) polymorphisms of TCF7L2 gene confer susceptibility to type 2 diabetes mellitus in Asian Indians. 17697858

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The T allele of rs7903146 increased Type 2 diabetes risk with an odds ratio (OR) of 1.32 (95% CI: 1.13-1.52; P = 0.0002) in community-based cases, but this OR was lower than the OR of cases enriched for genetic studies [1.58 (95% CI: 1.38-1.80), P = 1.4 x 10(-11)] and the combined OR of meta-analysis of 10 studies to date on rs7903146 [1.48 (95% CI: 1.41-1.54), P < 10(-20)]. 17725629

2007

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In white European populations, we found that the rs7903146 T allele was more associated with T2D in 3,547 non-obese individuals (odds ratio (OR) = 1.88 (1.69-2.10)) than in 1,110 class III obese subjects (OR = 1.24 (1.03-1.50)). 18239663

2008

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The minor allele of each variant was significantly associated with type 2 diabetes; the greatest risk of developing the disease was conferred by rs7903146, with an allelic odds ratio (OR) of 1.31 (95% CI: 1.11 - 1.56, p = 1.96 x 10(-3)). 18291022

2008

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Notably, the frequency of the type 2 diabetes-associated CT/TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects (52.8%; P = 0.03), to the same extent as in type 2 diabetic subjects (54.1%, P = 3 x 10(-7)), compared with control subjects (44.8%) and type 1 diabetic subjects (43.3%). 18310307

2008

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We report replication of association of four of the six SNPs with T2DM in this Khatri Sikh sample [rs7903146, (p = 0.010); rs11196205, (p = 0.011); rs10885409, (p = 0.002) and rs4918789, (p = 0.029)], under a dominant model conferring odds ratios (ORs) of 1.39, 1.44, 1.57 and 1.36, respectively. 18397358

2008

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE One TCF7L2 SNP (rs7903146) showed compelling evidence of association with type 2 diabetes (admixture-adjusted additive P [P(a)] = 1.59 x 10(-6)). 18443202

2008

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The T2D risk increased strongly when risk alleles, including the previously discovered T2D-associated TCF7L2 rs7903146 SNP, were combined (8.68-fold for the 14% of French individuals carrying 18 to 30 risk alleles with an allelic OR of 1.24). 18461161

2008

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Comparison between allele and genotype frequencies of these SNPs in patients and controls showed marginal association for rs7903146 and rs290487 with type 2 diabetes (p = 0.063, OR 1.982, 95% CI 1.128-3.485; p = 0.071, OR 1.237, 95% CI 0.983-1.557, respectively). 18493736

2008

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94). 18498634

2008