Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05. 31759989

2020

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Our results provide evidence that genetic variation in <i>TCF7L2</i> rs7903146 could increase risk for peripheral arterial disease in patients exhibiting long-standing type 2 diabetes. 31775533

2020

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT Fine-mapping of the TCF7L2 locus suggested one type 2 diabetes association signal shared between Europeans and Africans (indexed by rs7903146) and a distinct African-specific signal (indexed by rs17746147). 31049640

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. 31118516

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The rs2476601C/T, rs689A/T, and rs7903146C/T polymorphisms were found to be associated with the risk of LADA, thereby indicating that, genetically, LADA could be an admixture of both T1D and T2D. 30456822

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The presence of the <i>TCF7L2</i> rs7903146 T allele in patients with T2DM was associated with increased secretion of insulin response to a mixed-meal test. 30700996

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We investigate the association between gene variant rs7903146 and metabolic parameters and examine in vitro and ex vivo gene expression of <i>TCF7L2</i> in human adipose tissue and progenitor cells from two independent populations of young healthy men with increased risk of type 2 diabetes due to low birth weight (LBW). 30721637

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In conclusion, rs7903146 and rs12255372 were significantly associated with T2DM in the specified Northern Iranian population. 30776466

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. 30814579

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We found that the T allele of rs7903146 was significantly associated with T2D risk (odds ratio of 1.59 for T allele, <i>p</i> = 0.005). 30899283

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In conclusion, our study provided evidence that a T2D-independent path was identified out of the pleiotropic effect of rs7903146 on IS. 30980227

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Fine-mapping of the TCF7L2 locus suggested one type 2 diabetes association signal shared between Europeans and Africans (indexed by rs7903146) and a distinct African-specific signal (indexed by rs17746147). 31049640

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Our results suggest that the TCF7L2 rs7903146 variant affects markers of insulin resistance and glycemic response to metformin in newly diagnosed patients with T2D within the first year of metformin treatment. 31070566

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Moreover, the rs7903146 polymorphism was not significantly associated with T2D development at either 6 months (P=0.72) or 1 year (P=0.64). 31121319

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Islet ATAC-seq peaks overlap with 13 SNPs associated with T2D (e.g. rs7903146, rs2237897, rs757209, rs11708067 and rs878521 near TCF7L2, KCNQ1, HNF1B, ADCY5 and GCK, respectively) and with additional 67 SNPs in LD with known T2D SNPs (e.g. 31123324

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We investigated potential interactions between body mass index (BMI) and genotypes of human leukocyte antigen (HLA), TCF7L2-rs7903146, and FTO-rs9939609 in relation to the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes. 31125083

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In conclusion, our findings supported that <i>TCF7L2</i> rs7903146 polymorphism could be used to identify individuals at high risk of developing T2DM in Asians and Caucasians. 31312259

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Serotonin was significantly associated with the rs7903146 genotype after full adjustment including type 2 diabetes and further top ranked metabolites. 31492908

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Clinical Impact of the TCF7L2 Gene rs7903146 Type 2 Diabetes Mellitus Risk Polymorphism in Women with Gestational Diabetes Mellitus: Impaired Glycemic Control and Increased Need of Insulin Therapy. 31546272

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005). 31676834

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Adropin peptide may have roles in T2DM pathogenesis due to several roles in glucose tolerance, decrement of insulin resistance, lipid metabolism and energy homoeostasis.<b>Aim:</b> To evaluate the serum level of adropin in T2DM patients and comparing with healthy individuals as well as assessing frequency of rs7903146 genotypes/alleles in patients and control groups.<b>Methods:</b> We analysed the frequency of rs7903146 genotypes/alleles in 93 patients with T2DM disease and 53 healthy individuals by the method of polymerase chain reaction-restriction fragment length polymorphism analysis. 31818149

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Interestingly, the highest level of adropin was detected in T2DMpatients with rs7903146T/T genotype.<b>Conclusion:</b> Our analysis showed higher level of adropin in T2DM patients and increased risk of T2DM with rs7903146T/T and rs7903146C/T genotypes. 31818149

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Interestingly, the highest level of adropin was detected in T2DMpatients with rs7903146T/T genotype.<b>Conclusion:</b> Our analysis showed higher level of adropin in T2DM patients and increased risk of T2DM with rs7903146T/T and rs7903146C/T genotypes. 31818149

2019

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
C 0.900 GeneticVariation GWASCAT Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia. 30470734

2018