|
rs9939609
|
|
Malignant Neoplasms
|
|
0.790 |
GeneticVariation
|
BEFREE |
Variants (such as rs9939609) in the fat mass- and obesity-associated (FTO) gene have been associated with obesity, type 2 diabetes, some cancers, and alcohol consumption.
|
23771786 |
2013 |
|
rs9939609
|
|
Malignant Neoplasms
|
|
0.790 |
GeneticVariation
|
BEFREE |
The rs9939609 polymorphism in the FTO gene has recently been implicated as a risk factor for some types of cancer, such as breast, pancreatic, and prostate cancers.
|
29260910 |
2018 |
|
rs9939609
|
|
Malignant Neoplasms
|
|
0.790 |
GeneticVariation
|
BEFREE |
The rs9939609 A allele, which was associated with higher BMI in the sample, was inversely associated with overall (odds ratio (OR) versus all controls = 0.93; 95% confidence interval (CI): 0.85-1.02 p = 0.12 per allele) and low-grade (OR = 0.90; 0.81-0.99 p = 0.03 per allele) prostate cancer risk, but positively associated with high-grade cancer among cases (OR high- versus low-grade cancer = 1.16; 0.99-1.37 p = 0.07 per allele).
|
20976066 |
2010 |
|
rs9939609
|
|
Malignant Neoplasms
|
|
0.790 |
GeneticVariation
|
BEFREE |
The study objective was to assess the prevalence of cardiovascular disease risk factors in patients treated for childhood cancer (<i>N</i> = 101) and to determine the involvement of clinical (cancer type and therapy) and/or genetic (<i>FTO</i> gene rs9939609 polymorphism) factors.
|
29675043 |
2018 |
|
rs9939609
|
|
Malignant Neoplasms
|
|
0.790 |
GeneticVariation
|
BEFREE |
Besides, in the subgroup analysis of ethnicity, our results indicated that rs9939609 polymorphism was significantly associated with cancer risk in Asians.
|
26931363 |
2017 |
|
rs9939609
|
|
Malignant Neoplasms
|
|
0.790 |
GeneticVariation
|
BEFREE |
Our meta-analysis indicated that there was no association between FTO rs9939609 polymorphism and the increased risk of c</span>ancer, although this polymorphism was marginally associated with pancreatic cancer.
|
22396042 |
2012 |
|
rs9939609
|
|
Malignant Neoplasms
|
|
0.790 |
GeneticVariation
|
BEFREE |
Among 22,799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up.
|
21179003 |
2011 |
|
rs9939609
|
|
Malignant Neoplasms
|
|
0.790 |
GeneticVariation
|
BEFREE |
However, <i>FTO</i> rs9939609 variant was associated with some types of cancer in the subgroup analysis.
|
28881622 |
2017 |
|
rs9939609
|
|
Malignant Neoplasms
|
|
0.790 |
GeneticVariation
|
BEFREE |
A cross-sectional study examined 4839 subjects in the population-based Malmö Diet and Cancer study with dietary data (from a modified diet history method) and information on the genetic variant FTO (rs9939609).
|
19726594 |
2009 |
|
rs1800625
|
|
Malignant Neoplasms
|
|
0.720 |
GeneticVariation
|
BEFREE |
Therefore, we performed a systematic review to identify statistical evidence of the association between the 3 polymorphisms rs2070600 G/S (82G>S), rs1800624 T/A ( -374 T>A) and rs1800625C/T (-429 C>T) and the risk of cancer.
|
26011358 |
2015 |
|
rs1800625
|
|
Malignant Neoplasms
|
|
0.720 |
GeneticVariation
|
BEFREE |
We failed to get an effective conclusion about the association between the rs1800624 and rs1800625 polymorphisms and cancer risk in overall comparison.
|
26011358 |
2015 |
|
rs1800625
|
|
Malignant Neoplasms
|
|
0.720 |
GeneticVariation
|
BEFREE |
CONCLUSIONS In conclusion, the RAGE rs1800625 polymorphism was associated with increased overall cancer risk in Asians in recessive genetic model.
|
31534114 |
2019 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results showed a significant association between HOTAIR rs920778 polymorphism and increased cancer risk under all five genetic models, as well as in Asians subgroup analysis based on ethnicity, digestive and gynecologic cancer group based on cancer type.
|
30941992 |
2019 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The summary results indicated that HOTAIR rs920778 increased the cancer risk in recessive model (OR = 1.61, 95% CI = 1.08-2.41, Pheterogeneity<0.001).
|
28159929 |
2017 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The pooled analyses detected significant associations between the rs920778 polymorphism and increased susceptibility to cancer in recessive, dominant, allelic, homozygous, and heterozygous models.
|
29463216 |
2018 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, no significant associations between the HOTAIR polymorphisms (rs920778, rs4759314 and rs1899663) and cancer risk were observed.
|
27010768 |
2016 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
A naturally occurring functional single nucleotide polymorphism (SNP) rs920,778 (C→T) in the intronic enhancer of HOTAIR gene has been demonstrated to affect HOTAIR expression and cancer susceptibility.
|
25980897 |
2015 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The HOTAIR single nucleotide polymorphisms (SNPs) rs920778 (C > T) and rs12826786 (C > T) present in the intronic enhancer and promoter regions of HOTAIR, respectively, are associated with expression, cancer susceptibility, and patient prognosis in some tumor types.
|
28083786 |
2017 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings imply that rs920778 polymorphism does not affect total cancer presence and the effect on specific cancer types is also weak in the Japanese population.
|
31759985 |
2020 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The pooled data showed that rs920778 polymorphism was significantly associated with an increased cancer risk in all five genetic models in Chinese population.
|
28938673 |
2017 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results also suggested that other SNPs were correlated with overall cancer risk, namely, two in HOTAIR (HOX transcript antisense RNA: rs920778C/T and rs7958904 G/C) and two in PRNCR1 (rs1016343C/T and rs16901946 A/G).
|
28342449 |
2017 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
HOTAIR SNP rs920778, rs7958904 and rs874945 are susceptible to cancer risk.
|
27965458 |
2017 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis showed that HOTAIR polymorphisms of rs12826786 and rs920778 were correlated with increased cancer risk, while rs7958904, rs4759314, rs874945, and rs1899663 were not.
|
29497311 |
2018 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the results indicated that HOTAIR polymorphism rs920778 was more generally associated with c</span>ancer risk, particularly in Asians, while rs4759314 was a risk factor for gastric cancer.
|
27246974 |
2016 |
|
rs920778
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Considering the single nucleotide polymorphism (SNP) rs920778 (C>T) could influence HOTAIR expression and cancer predisposition in other malignancies, we herein investigated the association between rs920778 status and cervical cancer susceptibility in a Chinese population.
|
27229487 |
2016 |