rs1800566
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
"NQO1 Gene C609T Polymorphism (dbSNP: rs1800566) and Digestive Tract Cancer Risk: A Meta-Analysis."
|
29652514 |
2019 |
rs2585428
|
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
<b>Aim:</b> rs2585428 and rs4809960 polymorphisms were significantly associated with overall cancer risk, but there is no evidence regarding the overall colorectal cancer (CRC) risk.
|
31802707 |
2020 |
rs4809960
|
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
<b>Aim:</b> rs2585428 and rs4809960 polymorphisms were significantly associated with overall cancer risk, but there is no evidence regarding the overall colorectal cancer (CRC) risk.
|
31802707 |
2020 |
rs7799039
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Conclusion:</b> In conclusion, our study suggests that the <i>LEP</i> rs7799039 G>A polymorphism might contribute to the development of cancer.
|
31114233 |
2019 |
rs1138272
|
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
<b>Conclusion:</b> The TT genotype of the <i>GSTP1</i> rs1138272 polymorphism is likely related to the susceptibility to overall cancer in the Asian and African populations and, specifically, "Colorectal" and "Head and neck" cancers in the Caucasian population.
|
30740061 |
2018 |
rs80357086
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Conclusions:</b> A high proportion of Japanese HBOC patients showed the <i>BRCA1</i> L63X mutation, and the clinical characteristics of breast cancer in patients with this mutation might differ from those in patients with other <i>BRCA1</i> or <i>BRCA2</i> mutations, in terms of the subtype and nuclear grade of the resultant cancer.
|
31143373 |
2019 |
rs11614913
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
<b>Conclusions:</b> The present meta-analysis suggests that mir-196a-2 rs11614913 may contribute to the risk of cancer especially in Asians.
|
30930933 |
2019 |
rs367597251
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Methods:</b> Osteosarcoma cancer cell line MG-63 was transfected with Ras gene with G12V and Y40C site mutation.
|
31126199 |
2019 |
rs11187842
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Objectives:</b> In the current study, we conducted a meta-analysis to more accurately evaluate the relationships between <i>PLCE1</i> (rs2274223, rs3765524, rs753724, rs11187842, and rs7922612) single nucleotide polymorphisms (SNPs) and risk for different types of cancer.
|
30619753 |
2018 |
rs7922612
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Objectives:</b> In the current study, we conducted a meta-analysis to more accurately evaluate the relationships between <i>PLCE1</i> (rs2274223, rs3765524, rs753724, rs11187842, and rs7922612) single nucleotide polymorphisms (SNPs) and risk for different types of cancer.
|
30619753 |
2018 |
rs9344
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Results:</b> Overall, the cumulative findings demonstrated that <i>CCND1</i> polymorphism (rs9344) was not significantly associated with cancer risk in all the genetic models studied (dominant model: GG vs GA+AA: OR (95%CI) = 0.81 (0.60-1.09), <i>P</i>=0.17; recessive model: GG+GA vs AA: OR (95%CI) = 1.23 (0.96-1.59), <i>P</i>=0.11; co-dominant model: <b>GG vs AA: OR (95%CI) = 1.35 (0.93-1.97), <i>P</i>=0.12;</b> co-dominant model: <b>(GG vs GA: OR (95%CI) = 1.16 (0.85-1.59), <i>P</i>=0.34</b>; allelic model: A vs G: OR (95%CI) = 1.20 (1.14-2.85), <i>P</i>=0.23; allelic model: G vs A: OR (95%CI) = 0.83 (0.62-1.12), <i>P</i>=0.23).
|
30361291 |
2018 |
rs402710
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>CLPTM1L</i> gene rs402710 (C > T) and rs401681 (C > T) polymorphisms associate with decreased cancer risk: a meta-analysis.
|
29254260 |
2017 |
rs401681
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
<i>CLPTM1L</i> gene rs402710 and rs401681 polymorphisms thus have a protective association with various types of cancer, especially lung cancer among Asians.
|
29254260 |
2017 |
rs2736098
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
<i>TERT</i> rs2736098 (Ex2-659G>A) polymorphism and cancer susceptibility: evidence from a comprehensive meta-analysis.
|
29221218 |
2017 |
rs4975616
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
3'UTR variant of HADH, rs221347 and rs4975616, located within known cancer risk locus 5p15.33, were specific to risk of laryngeal cancer.
|
28582492 |
2017 |
rs3746444
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
35, 95% CI: 1.09-1.67), and rs3746444 was associated with liver cancer in the subgroup of cance</span>r types.
|
23725137 |
2013 |
rs1217691063
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Cancer risk may be increased in individuals with the homozygous genotype for the MTHFR 677C-->T polymorphism who have low status of methyl-related nutrients including folate.
|
14608109 |
2003 |
rs121912664
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because protocols for cancer-risk management in Li-Fraumeni or related syndromes are debatable, extreme care should prevail in predictive testing of children for R337H.
|
19717094 |
2009 |
rs1443496641
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Cancer patients with severe antimetabolite toxicity were evaluated for methylenetetrahydrofolate reductase (MTHFR) gene C667T, thymidilate synthase (TS) gene 5' UTR variable number of tandem repeats (VNTR), dihydroprymidine dehydrogenase (DPYD) gene IVS14+1G/A, Xeroderma pigmentosum (XPD) gene Lys751Gln and X-ray repair cross-complementing group 1 (XRCC1) gene Arg399Gln polymorphisms.
|
22799365 |
2012 |
rs6220
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Cancer-specific survival was significantly associated with the CA repeat polymorphism, rs12423791, and rs6220 (P = 0.013, 0.014, and 0.014, respectively).
|
23530598 |
2013 |
rs12423791
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
When the sum of the risk genetic factors in each LD block (19-repeat allele, C allele of rs12423791, or C-T haplotype) was considered, patients with all the risk factors had significantly shorter cancer specific-survival than those with 0-2 risk factors (P = 0.0003).
|
23530598 |
2013 |
rs121913500
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.
|
24986863 |
2014 |
rs121913500
|
|
Malignant Neoplasms
|
|
0.060 |
GeneticVariation
|
BEFREE |
Cancer cells heterozygous for the IDH1(R132H) mutation exhibited less IDH-mediated production of NADPH, such that after exposure to ionizing radiation (IR), there were higher levels of reactive oxygen species, DNA double-strand breaks, and cell death compared with IDH1 wild-type cells.
|
26363012 |
2015 |
rs118101777
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Cancer cells heterozygous for the IDH1(R132H) mutation exhibited less IDH-mediated production of NADPH, such that after exposure to ionizing radiation (IR), there were higher levels of reactive oxygen species, DNA double-strand breaks, and cell death compared with IDH1 wild-type cells.
|
26363012 |
2015 |
rs104893626
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Cancer cell fraction analysis in WM and IgM MGUS patients showed CXCR4(S338X) mutations were primarily subclonal, with highly variable clonal distribution (median 35·1%, range 1·2-97·5%).
|
26659815 |
2016 |