|
rs874945
|
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
The results showed that cancer risk was elevated in recessive mutation of rs12826786 (TT vs CC+CT: OR =1.55, 95% CI =1.19, 2.03; TT+CT vs CC: OR =1.23, 95% CI =1.04, 1.46; TT vs CC: OR =1.67, 95% CI =1.24, 2.24; T vs C: OR =1.24, 95% CI =1.09, 1.40) and rs920778 (TT vs CC+CT: OR =1.73, 95% CI =1.30, 2.30; TT+CT vs CC: OR =1.40, 95% CI =1.16, 1.70; TT vs CC: OR =1.83, 95% CI =1.25, 2.68; T vs C: OR =1.37, 95% CI =1.18, 1.59), while the results for polymorphisms of rs7958904, rs4759314, rs874945, and rs1899663 were insignificant.
|
29497311 |
2018 |
|
rs874945
|
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, there is no significant association between SNPs variants and cancer risk under any five genetic models for rs4759314, rs1899663 and rs874945.
|
30941992 |
2019 |
|
rs874945
|
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, no significant association was identified between the rs874945, rs4759314 and rs1899663 polymorphisms and cancer susceptibility.
|
27791260 |
2017 |
|
rs874945
|
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, no significant association was found between the rs1899663, rs874945, and rs4759314 polymorphisms and susceptibility of cancer.
|
29463216 |
2018 |
|
rs874945
|
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
HOTAIR SNP rs920778, rs7958904 and rs8749</span>45 are susceptible to cancer risk.
|
27965458 |
2017 |
|
rs12826786
|
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
The HOTAIR single nucleotide polymorphisms (SNPs) rs920778 (C > T) and rs12826786 (C > T) present in the intronic enhancer and promoter regions of HOTAIR, respectively, are associated with expression, cancer susceptibility, and patient prognosis in some tumor types.
|
28083786 |
2017 |
|
rs12826786
|
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our meta-analysis showed that HOTAIR polymorphisms of rs12826786 and rs920778 were correlated with increased cancer risk, while rs7958904, rs4759314, rs874945, and rs1899663 were not.
|
29497311 |
2018 |
|
rs12826786
|
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
For the rs12826786 polymorphism, we identified it significantly increased susceptibility to cancer risk in all genetic models rather than heterozygous models.
|
29463216 |
2018 |
|
rs2069514
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The previously published data on the association between CYP1A2*1C (rs2069514) and CYP1A2*1F (rs762551) polymorphisms and cancer risk have remained controversial.
|
25472037 |
2015 |
|
rs2069514
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results showed that no significant associations with the risk of cancer were found in any model (allele contrast, codominant, dominant, or recessive model) in terms of rs2069514 and rs3569413 when all studies were pooled into a meta-analysis.
|
23462460 |
2013 |
|
rs2046210
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
In The Cancer Genome Atlas samples, the AA/AG risk genotypes of SNP rs2046210 were associated with a significantly higher expression level of the AKAP12 gene and a lower level of the ESR1 gene in tumor tissue.
|
26645718 |
2016 |
|
rs2046210
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
With the exception of rs2046210 at 6q25.1, the seven other SNPs showed a stronger association with ER-positive than ER-negative cancer.
|
23535825 |
2013 |
|
rs9600079
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped five single-nucleotide polymorphism (SNP): rs13385191 (chromosome 2p24), rs12653946 (5p15), rs1983891 (6p21), rs339331 (6p22), and rs9600079 (13q22), in 7,956 prostate cancer cases and 8,148 controls from a series of nested case-control studies within the National cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3).
|
22056501 |
2012 |
|
rs9325782
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In analysis of selected candidate cancer susceptibility genes, two MSR1 SNPs (rs9325782, GEE p = 0.008 and rs2410373, FBAT p = 0.021) were associated with prostate cancer and three ERBB4 SNPs (rs905883 GEE p = 0.0002, rs7564590 GEE p = 0.003, rs7558615 GEE p = 0.0078) were associated with breast cancer.
|
17903305 |
2007 |
|
rs9257445
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs9257445 (ZNF311) was associated with TL in HetAT subjects and rs6060627 (BCL2L1) modified cancer risk in HetAT and non-HetAT women.Our findings suggest that carriage of an ATM mutation impacts on the age-related TL shortening and that TL per se is not related to cancer risk in ATM carriers.
|
28981872 |
2017 |
|
rs895919
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 are risk factors for cancer development, whereas mir-149 rs2292832 and miR-27a rs895919 are not associated with cancer risk.
|
24278149 |
2013 |
|
rs7923837
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
T2D-related variants HHEX rs7923837, TCF7L2 rs290481 and CDKAL1 rs7756992 increased cancer risk in patients with diabetes.
|
24468095 |
2014 |
|
rs7859384
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
A protective effect of SNP rs7859384 GA/GG genotypes was observed among individuals with BMI > 24 (P = 0.025, OR = 0.74, 95% CI = 0.56-0.96), without hypertension (P = 0.037, OR = 0.79, 95% CI = 0.63-0.99), without family history of cancer (P = 0.048, OR = 0.83, 95% CI = 0.68-1.00).
|
31038847 |
2019 |
|
rs74345699
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Functional analysis indicated that the cancer risk alleles of four candidates (rs74345699 and rs62355900 [iCHAV1], rs16886397 [iCHAV2a], and rs17432750 [iCHAV3]) increased MAP3K1 transcriptional activity.
|
25529635 |
2015 |
|
rs7082598
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The single most significant SNPs from each gene associated with CIN3/cancer were PRDX3 rs7082598 (P(trend)<0.0001), and RPS19 rs2305809 (P(trend)=0.0007), respectively.
|
22496757 |
2012 |
|
rs6993464
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conducted a study in order to examine the association between IPMN and single nucleotide polymorphisms (SNPs) from the 8q24 region, namely rs10505477, rs6983267, rs7014346, rs6993464, previously reported to influence general cancer susceptibility.
|
27689194 |
2016 |
|
rs6983269
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although 8q24 harbours variants that predispose to all three cancers, the susceptibility loci within the region appear to be specific for the different cancer types with the exception of rs6983269 in colon and prostate cancer.
|
19005751 |
2009 |
|
rs6787344
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Five tagging single-nucleotide polymorphisms (rs2248690, rs2070633, rs2070635, rs4917, and rs6787344) capturing the common genetic variation of the fetuin-A coding gene alpha(2)-Heremans-Schmid glycoprotein (AHSG) were genotyped in a case-cohort comprising 214 MI cases, 154 ischemic stroke cases, and 2152 persons who remained free of cardiovascular disease events in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.
|
20031641 |
2009 |
|
rs62355900
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Functional analysis indicated that the cancer risk alleles of four candidates (rs74345699 and rs62355900 [iCHAV1], rs16886397 [iCHAV2a], and rs17432750 [iCHAV3]) increased MAP3K1 transcriptional activity.
|
25529635 |
2015 |
|
rs4975616
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
3'UTR variant of HADH, rs221347 and rs4975616, located within known cancer risk locus 5p15.33, were specific to risk of laryngeal cancer.
|
28582492 |
2017 |