|
rs833061
|
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
In our work, we searched for an association between the -460C> (rs833061) and -634G>C (rs2010963) polymorphisms of the VEGF gene and the occurrence of AMD and its dry and wet forms.
|
19761764 |
2009 |
|
rs833061
|
|
Diabetic Retinopathy
|
|
0.040 |
GeneticVariation
|
BEFREE |
After adjusting for covariates, a significant association of DR was observed with the homozygous genotype of the minor allele for promoter SNPs rs699947 (odds ratio (OR)=3.54, 95% confidence interval (CI): 1.12-11.19), rs833061 (OR=3.72, 95% CI: 1.17-11.85) and rs13207351 (OR=3.76, 95% CI: 1.21-11.71).
|
22162628 |
2011 |
|
rs833061
|
|
hypertensive nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The haplotype analysis revealed that two haplotypes, CGTC and CATC (in the order of VEGF -2578 C>A (rs699947), -1154 G>A (1570360), -460 C>T (rs833061), and +936 C>T (3025039)), were significantly associated with hypertensive nephropathy in Hispanic patients.
|
21080079 |
2011 |
|
rs833061
|
|
Hypothyroidism
|
|
0.010 |
GeneticVariation
|
BEFREE |
The presence of C-allele in rs833061 and the T-allele in rs3025039 polymorphism of VEGFA were associated with significantly higher risk of hypothyroidism (OR: 10.0 p = 0.041 and OR: 10.5; p = 0.015, respectively).
|
22439647 |
2012 |
|
rs833061
|
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our study shows that VEGFA rs699947 and rs833061 and VEGFR2 rs2071559 polymorphisms do not modify the risk of suffering AMD in a Spanish population.
|
23971975 |
2013 |
|
rs833061
|
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.
|
23761723 |
2013 |
|
rs833061
|
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Blood and tumor tissue from 83 patients with NSCLC were examined for VEGF -460T/C (rs833061) and VEGF +405G/C (rs2010963) SNPs using the SNaPshot method.
|
23064377 |
2013 |
|
rs833061
|
|
Endometriosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the rs833061 (T>C) and rs2010963 (G>C) polymorphisms of the VEGF gene did not appear to have an influence on endometriosis susceptibility.
|
23613250 |
2013 |
|
rs833061
|
|
Glycogen storage disease type II
|
|
0.010 |
GeneticVariation
|
BEFREE |
VEGF A (rs699947 and rs833061) and VEGFR2 (rs2071559) gene polymorphisms are not associated with AMD susceptibility in a Spanish population.
|
23971975 |
2013 |
|
rs833061
|
|
Renal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We were unable to replicate the association of the -460T/C (rs833061) polymorphism with renal cancer risk.
|
23073296 |
2013 |
|
rs833061
|
|
Malignant neoplasm of mouth
|
|
0.010 |
GeneticVariation
|
BEFREE |
Many studies have examined the association between the VEGF +936C/T (rs833061) and +460C/T (rs3025039) gene polymorphisms and oral cancer risk in various populations, but their results have been inconsistent.
|
24057253 |
2013 |
|
rs833061
|
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Blood and tumor tissue from 83 patients with NSCLC were examined for VEGF -460T/C (rs833061) and VEGF +405G/C (rs2010963) SNPs using the SNaPshot method.
|
23064377 |
2013 |
|
rs833061
|
|
Malignant neoplasm of kidney
|
|
0.010 |
GeneticVariation
|
BEFREE |
We were unable to replicate the association of the -460T/C (rs833061) polymorphism with renal cancer risk.
|
23073296 |
2013 |
|
rs833061
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We identified two promoter SNPs (rs833061 and rs1570360) were associated with susceptibility to HCC (rs8330</span>61: ptrend = 0.008 in Youan_Beijing samples, ptrend = 0.01 in Guangxi samples, ptrend = 0.01 in Jiangsu samples. rs1570360: ptrend = 0.00003 in Youan_Beijing samples, ptrend = 0.006 in Guangxi samples, ptrend = 0.02 in Jiangsu samples).
|
23404364 |
2013 |
|
rs833061
|
|
Lip and Oral Cavity Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Many studies have examined the association between the VEGF +936C/T (rs833061) and +460C/T (rs3025039) gene polymorphisms and oral cancer risk in various populations, but their results have been inconsistent.
|
24057253 |
2013 |
|
rs833061
|
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
The meta-analysis results based on nine case-control studies with 2427 cases and 2037 controls showed that rs833061 had protective effects on AMD risk (TT vs. CT+CC: OR=0.58, 95% CI=0.41-0.81), whereas rs1413711 (TT vs. CT+CC: OR=1.46, 95% CI=1.10-1.93) and rs3025039 (TT vs. CC: OR=1.87, 95% CI=1.15-3.02; TT vs. CT+CC: OR=2.09, 95% CI=1.30-3.37) represented as risk factors for AMD.
|
24689893 |
2014 |
|
rs833061
|
|
Diabetic Retinopathy
|
|
0.040 |
GeneticVariation
|
BEFREE |
After adjustment for covariates, significant association of DR remained with the homozygous genotype of the minor allele for the SNPs rs699947 (odds ratio [OR] = 3.54, 95% confidence interval [CI]: 1.12-11.19), rs833061 (OR = 3.72, 95% CI: 1.17-11.85), rs13207351 (OR = 3.76, 95% CI: 1.21-11.71), and rs2146323 (OR = 2.8, 95% CI: 1.46-5.37) in the VEGF gene as well as the SNP rs2071559 (OR = 1.62, 95% CI: 1.08-2.41) in the KDR gene.
|
24623964 |
2014 |
|
rs833061
|
|
Psoriasis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this meta-analysis was to investigate large-scale evidence to determine the degree to which four common VEGF polymorphisms (+405C>G [dbSNP: rs2010963], -460T>C [dbSNP: rs833061], -2578C>A [dbSNP: rs699947], and -1154G>A [dbSNP: rs1570360]) are associated with susceptibility to psoriasis.
|
24678886 |
2014 |
|
rs833061
|
|
Diabetic Retinopathy
|
|
0.040 |
GeneticVariation
|
BEFREE |
A significant relationship between VEGF+936C/T (rs3025039) polymorphism and DR was found in a recessive model (OR = 3.19, 95% CI = 1.20-8.41, and P(z) = 0.01) in Asian and overall populations, while a significant association was also found between -460T/C (rs833061) polymorphism and DR risk under a recessive model (OR = 2.12, 95% CI = 1.12-4.01, and P(z) = 0.02).CONCLUSIONS.
|
24868559 |
2014 |
|
rs833061
|
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
rs833061 and rs699947 on promoter gene of vascular endothelial growth factor (VEGF) and associated lung cancer susceptibility and survival: a meta-analysis.
|
25468805 |
2014 |
|
rs833061
|
|
Primary malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of this meta-analysis is to generate large-scale evidence on whether common vascular endothelial growth factor (VEGF) gene polymorphisms (-2578C/A [dbSNP: rs699947] and -460C/T [dbSNP: rs833061]) are associated with lung cancer.
|
23982876 |
2014 |
|
rs833061
|
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of this meta-analysis is to generate large-scale evidence on whether common vascular endothelial growth factor (VEGF) gene polymorphisms (-2578C/A [dbSNP: rs699947] and -460C/T [dbSNP: rs833061]) are associated with lung cancer.
|
23982876 |
2014 |
|
rs833061
|
|
Malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
rs833061 and rs699947 on promoter gene of vascular endothelial growth factor (VEGF) and associated lung cancer susceptibility and survival: a meta-analysis.
|
25468805 |
2014 |
|
rs833061
|
|
Primary malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
rs833061 and rs699947 on promoter gene of vascular endothelial growth factor (VEGF) and associated lung cancer susceptibility and survival: a meta-analysis.
|
25468805 |
2014 |
|
rs833061
|
|
Malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of this meta-analysis is to generate large-scale evidence on whether common vascular endothelial growth factor (VEGF) gene polymorphisms (-2578C/A [dbSNP: rs699947] and -460C/T [dbSNP: rs833061]) are associated with lung cancer.
|
23982876 |
2014 |