|
rs833061
|
|
Tetralogy of Fallot
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of study participants and type of disease demonstrated that the rs833061 polymorphism was significantly correlated with the risk of CHD in Asians under additive genetic model, and the rs3025039 polymorphism was significantly correlated with the risk of Tetralogy of Fallot (TOF) in dominant, recessive and allele models.
|
30689460 |
2018 |
|
rs833061
|
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
The VEGF polymorphism rs833061 was strongly associated with increased risk for glioma (odds ratio = 164.85) and glioblastoma (odds ratio = 155.66), confirmed after Bonferroni correction.
|
29584591 |
2018 |
|
rs833061
|
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of study participants and type of disease demonstrated that the rs833061 polymorphism was significantly correlated with the risk of CHD in Asians under additive genetic model, and the rs3025039 polymorphism was significantly correlated with the risk of Tetralogy of Fallot (TOF) in dominant, recessive and allele models.
|
30689460 |
2018 |
|
rs833061
|
|
Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The VEGF polymorphism rs833061 was strongly associated with increased risk for glioma (odds ratio = 164.85) and glioblastoma (odds ratio = 155.66), confirmed after Bonferroni correction.
|
29584591 |
2018 |
|
rs833061
|
|
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The VEGF polymorphism rs833061 was strongly associated with increased risk for glioma (odds ratio = 164.85) and glioblastoma (odds ratio = 155.66), confirmed after Bonferroni correction.
|
29584591 |
2018 |
|
rs833061
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the case-control study, rs1042522 (<i>TP53</i>) was associated with a stronger risk for developing gastric cancer in the sample stratified for diffuse subtype patients when compared to the risk observed for the total cases; CTC haplotype (rs699947/rs833061/rs2010963 <i>VEGFA</i>) was associated with risk while rs699947 was associated with protection for gastric malignancy in the total sample.
|
30551681 |
2018 |
|
rs833061
|
|
Adult Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The VEGF polymorphism rs833061 was strongly associated with increased risk for glioma (odds ratio = 164.85) and glioblastoma (odds ratio = 155.66), confirmed after Bonferroni correction.
|
29584591 |
2018 |
|
rs833061
|
|
Childhood Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The VEGF polymorphism rs833061 was strongly associated with increased risk for glioma (odds ratio = 164.85) and glioblastoma (odds ratio = 155.66), confirmed after Bonferroni correction.
|
29584591 |
2018 |
|
rs833061
|
|
Exudative age-related macular degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
Pharmacogenetics of <i>VEGF-A</i> polymorphism rs833061 may play a positive role in response to anti-VEGF therapy for nAMD.
|
28400373 |
2017 |
|
rs833061
|
|
Idiopathic pulmonary arterial hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that the functional polymorphism rs833061T>C in VEGF gene promoter modulates VEGF expression and may be a valuable biomarker for predicting PAH susceptibility.
|
28120560 |
2017 |
|
rs833061
|
|
Squamous cell carcinoma of skin
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aims of this study were to further systematically clarify the potential association of rs833061 (-460 C>T) and rs1570360 (-1154 G>A), two SNPs of VEGF, with the risk of cSCC and the prognostic impacts on cSCC patients.
|
27729640 |
2016 |
|
rs833061
|
|
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, when the patients were stratified by tumor histology, squamous cell carcinoma (SCC) and adenocarcinoma (AC) had significantly different OS (Adjusted hazard ratio [aHR] = 0.76, 95% CI = 0.56-1.03 in SCC; aHR = 1.33, 95% CI = 0.98-1.82 in AC; P for heterogeneity = 0.01) and DFS (aHR = 0.75, 95% CI = 0.58-0.97 in SCC; aHR = 1.26, 95% CI = 1.00-1.60 in AC; P for heterogeneity = 0.004) according to the rs833061T>C genotypes.
|
27709850 |
2016 |
|
rs833061
|
|
Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, when the patients were stratified by tumor histology, squamous cell carcinoma (SCC) and adenocarcinoma (AC) had significantly different OS (Adjusted hazard ratio [aHR] = 0.76, 95% CI = 0.56-1.03 in SCC; aHR = 1.33, 95% CI = 0.98-1.82 in AC; P for heterogeneity = 0.01) and DFS (aHR = 0.75, 95% CI = 0.58-0.97 in SCC; aHR = 1.26, 95% CI = 1.00-1.60 in AC; P for heterogeneity = 0.004) according to the rs833061T>C genotypes.
|
27709850 |
2016 |
|
rs833061
|
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
Seven-locus (rs699947/rs833061/rs1570360/rs2010963/rs25648/rs833068/ rs833070) haploview analysis identified only CTGCCAG haplotype to be positively associated with CC [P=0.022; OR(95% CI)=1.74 (1.08-2.79)].
|
25541433 |
2015 |
|
rs833061
|
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Seven-locus (rs699947/rs833061/rs1570360/rs2010963/rs25648/rs833068/ rs833070) haploview analysis identified only CTGCCAG haplotype to be positively associated with CC [P=0.022; OR(95% CI)=1.74 (1.08-2.79)].
|
25541433 |
2015 |
|
rs833061
|
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Seven-locus (rs699947/rs833061/rs1570360/rs2010963/rs25648/rs833068/ rs833070) haploview analysis identified only CTGCCAG haplotype to be positively associated with CC [P=0.022; OR(95% CI)=1.74 (1.08-2.79)].
|
25541433 |
2015 |
|
rs833061
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present case-control study investigated the association of the four commonly studied single nucleotide polymorphisms (SNP) of VEGF-A, namely: -1154A/G (rs1570360), -2578C/A (rs699947), -634G/C (rs2010963) and -460T/C (rs833061) with BC susceptibility and aggressiveness in Moroccan women.
|
25148899 |
2014 |
|
rs833061
|
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.
|
25280384 |
2014 |
|
rs833061
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overall, VEGF rs833061 polymorphism was not associated with risk of prostate cancer (T versus C, OR = 1.14, 95% CI 0.91-1.44, P = 0.26; TT versus CC, OR = 1.09, 95% CI 0.67-1.76, P = 0.74; TT versus
|
24353087 |
2014 |
|
rs833061
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overall, VEGF rs833061 polymorphism was not associated with risk of prostate cancer (T versus C, OR = 1.14, 95% CI 0.91-1.44, P = 0.26; TT versus CC, OR = 1.09, 95% CI 0.67-1.76, P = 0.74; TT versus
|
24353087 |
2014 |
|
rs833061
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present case-control study investigated the association of the four commonly studied single nucleotide polymorphisms (SNP) of VEGF-A, namely: -1154A/G (rs1570360), -2578C/A (rs699947), -634G/C (rs2010963) and -460T/C (rs833061) with BC susceptibility and aggressiveness in Moroccan women.
|
25148899 |
2014 |
|
rs833061
|
|
Chronic Lymphocytic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we showed that homozygosity for rs699947/rs833061/rs2010963 ACG haplotype (ACG+/+ genotype) correlated with a reduced survival in CLL patients (ACG+/+ vs other genotypes: HR = 2.3, p = 0.002; recessive model).
|
24971577 |
2014 |
|
rs833061
|
|
Kidney Failure, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.
|
25280384 |
2014 |
|
rs833061
|
|
Endometriosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the rs833061 (T>C) and rs2010963 (G>C) polymorphisms of the VEGF gene did not appear to have an influence on endometriosis susceptibility.
|
23613250 |
2013 |
|
rs833061
|
|
Glycogen storage disease type II
|
|
0.010 |
GeneticVariation
|
BEFREE |
VEGF A (rs699947 and rs833061) and VEGFR2 (rs2071559) gene polymorphisms are not associated with AMD susceptibility in a Spanish population.
|
23971975 |
2013 |