|
rs833061
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>VEGFA</i> rs833061 polymorphism is significantly associated with the therapeutic efficiency of bevacizumab in CRC patients.
|
29285265 |
2017 |
|
rs833061
|
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
rs833061 and rs699947 on promoter gene of vascular endothelial growth factor (VEGF) and associated lung cancer susceptibility and survival: a meta-analysis.
|
25468805 |
2014 |
|
rs833061
|
|
Malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
rs833061 and rs699947 on promoter gene of vascular endothelial growth factor (VEGF) and associated lung cancer susceptibility and survival: a meta-analysis.
|
25468805 |
2014 |
|
rs833061
|
|
Primary malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
rs833061 and rs699947 on promoter gene of vascular endothelial growth factor (VEGF) and associated lung cancer susceptibility and survival: a meta-analysis.
|
25468805 |
2014 |
|
rs833061
|
|
Diabetic Retinopathy
|
|
0.040 |
GeneticVariation
|
BEFREE |
A significant relationship between VEGF+936C/T (rs3025039) polymorphism and DR was found in a recessive model (OR = 3.19, 95% CI = 1.20-8.41, and P(z) = 0.01) in Asian and overall populations, while a significant association was also found between -460T/C (rs833061) polymorphism and DR risk under a recessive model (OR = 2.12, 95% CI = 1.12-4.01, and P(z) = 0.02).CONCLUSIONS.
|
24868559 |
2014 |
|
rs833061
|
|
Diabetic Retinopathy
|
|
0.040 |
GeneticVariation
|
BEFREE |
After adjusting for covariates, a significant association of DR was observed with the homozygous genotype of the minor allele for promoter SNPs rs699947 (odds ratio (OR)=3.54, 95% confidence interval (CI): 1.12-11.19), rs833061 (OR=3.72, 95% CI: 1.17-11.85) and rs13207351 (OR=3.76, 95% CI: 1.21-11.71).
|
22162628 |
2011 |
|
rs833061
|
|
Diabetic Retinopathy
|
|
0.040 |
GeneticVariation
|
BEFREE |
After adjustment for covariates, significant association of DR remained with the homozygous genotype of the minor allele for the SNPs rs699947 (odds ratio [OR] = 3.54, 95% confidence interval [CI]: 1.12-11.19), rs833061 (OR = 3.72, 95% CI: 1.17-11.85), rs13207351 (OR = 3.76, 95% CI: 1.21-11.71), and rs2146323 (OR = 2.8, 95% CI: 1.46-5.37) in the VEGF gene as well as the SNP rs2071559 (OR = 1.62, 95% CI: 1.08-2.41) in the KDR gene.
|
24623964 |
2014 |
|
rs833061
|
|
Psoriasis
|
|
0.040 |
GeneticVariation
|
BEFREE |
An association was found between rs1800629 (TNF-α) and Type I psoriasis, and rs833061 (VEGF) and Type II psoriasis.
|
31148856 |
2020 |
|
rs833061
|
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Blood and tumor tissue from 83 patients with NSCLC were examined for VEGF -460T/C (rs833061) and VEGF +405G/C (rs2010963) SNPs using the SNaPshot method.
|
23064377 |
2013 |
|
rs833061
|
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Blood and tumor tissue from 83 patients with NSCLC were examined for VEGF -460T/C (rs833061) and VEGF +405G/C (rs2010963) SNPs using the SNaPshot method.
|
23064377 |
2013 |
|
rs833061
|
|
Tetralogy of Fallot
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of study participants and type of disease demonstrated that the rs833061 polymorphism was significantly correlated with the risk of CHD in Asians under additive genetic model, and the rs3025039 polymorphism was significantly correlated with the risk of Tetralogy of Fallot (TOF) in dominant, recessive and allele models.
|
30689460 |
2018 |
|
rs833061
|
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of study participants and type of disease demonstrated that the rs833061 polymorphism was significantly correlated with the risk of CHD in Asians under additive genetic model, and the rs3025039 polymorphism was significantly correlated with the risk of Tetralogy of Fallot (TOF) in dominant, recessive and allele models.
|
30689460 |
2018 |
|
rs833061
|
|
Chronic Lymphocytic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we showed that homozygosity for rs699947/rs833061/rs2010963 ACG haplotype (ACG+/+ genotype) correlated with a reduced survival in CLL patients (ACG+/+ vs other genotypes: HR = 2.3, p = 0.002; recessive model).
|
24971577 |
2014 |
|
rs833061
|
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
HIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking.
|
27981753 |
2017 |
|
rs833061
|
|
Malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
HIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking.
|
27981753 |
2017 |
|
rs833061
|
|
Primary malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
HIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking.
|
27981753 |
2017 |
|
rs833061
|
|
Endometriosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the rs833061 (T>C) and rs2010963 (G>C) polymorphisms of the VEGF gene did not appear to have an influence on endometriosis susceptibility.
|
23613250 |
2013 |
|
rs833061
|
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
However, weak correlations between 10 SNPs (CFH rs1329428 TT genotype, CFH rs3753394 CC genotype and T allele, CFH rs1410996 AA genotype, CFH rs800292 AA genotype, CFH rs800292 A allele, VEGF rs833061 TT genotype and C allele, VEGF rs2010963 CG genotype, VEGFR2 rs1531289 TT genotype, ARMS2 rs10490924 TT genotype, KCTD10 rs238104 GC genotype, rs1531289 T allele and ARMS2 rs10490924 T allele) and AMD were shown.
|
30696427 |
2019 |
|
rs833061
|
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, when the patients were stratified by tumor histology, squamous cell carcinoma (SCC) and adenocarcinoma (AC) had significantly different OS (Adjusted hazard ratio [aHR] = 0.76, 95% CI = 0.56-1.03 in SCC; aHR = 1.33, 95% CI = 0.98-1.82 in AC; P for heterogeneity = 0.01) and DFS (aHR = 0.75, 95% CI = 0.58-0.97 in SCC; aHR = 1.26, 95% CI = 1.00-1.60 in AC; P for heterogeneity = 0.004) according to the rs833061T>C genotypes.
|
27709850 |
2016 |
|
rs833061
|
|
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, when the patients were stratified by tumor histology, squamous cell carcinoma (SCC) and adenocarcinoma (AC) had significantly different OS (Adjusted hazard ratio [aHR] = 0.76, 95% CI = 0.56-1.03 in SCC; aHR = 1.33, 95% CI = 0.98-1.82 in AC; P for heterogeneity = 0.01) and DFS (aHR = 0.75, 95% CI = 0.58-0.97 in SCC; aHR = 1.26, 95% CI = 1.00-1.60 in AC; P for heterogeneity = 0.004) according to the rs833061T>C genotypes.
|
27709850 |
2016 |
|
rs833061
|
|
Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, when the patients were stratified by tumor histology, squamous cell carcinoma (SCC) and adenocarcinoma (AC) had significantly different OS (Adjusted hazard ratio [aHR] = 0.76, 95% CI = 0.56-1.03 in SCC; aHR = 1.33, 95% CI = 0.98-1.82 in AC; P for heterogeneity = 0.01) and DFS (aHR = 0.75, 95% CI = 0.58-0.97 in SCC; aHR = 1.26, 95% CI = 1.00-1.60 in AC; P for heterogeneity = 0.004) according to the rs833061T>C genotypes.
|
27709850 |
2016 |
|
rs833061
|
|
Psoriasis
|
|
0.040 |
GeneticVariation
|
BEFREE |
In addition, genetic complement, comprising the PGF rs2268615 AA genotype and the VEGFA -460 (rs833061) T allele, was significantly associated with the development of early-onset psoriasis (P < 0.03).
|
31545526 |
2020 |
|
rs833061
|
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
In our work, we searched for an association between the -460C> (rs833061) and -634G>C (rs2010963) polymorphisms of the VEGF gene and the occurrence of AMD and its dry and wet forms.
|
19761764 |
2009 |
|
rs833061
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the case-control study, rs1042522 (<i>TP53</i>) was associated with a stronger risk for developing gastric cancer in the sample stratified for diffuse subtype patients when compared to the risk observed for the total cases; CTC haplotype (rs699947/rs833061/rs2010963 <i>VEGFA</i>) was associated with risk while rs699947 was associated with protection for gastric malignancy in the total sample.
|
30551681 |
2018 |
|
rs833061
|
|
Malignant neoplasm of mouth
|
|
0.010 |
GeneticVariation
|
BEFREE |
Many studies have examined the association between the VEGF +936C/T (rs833061) and +460C/T (rs3025039) gene polymorphisms and oral cancer risk in various populations, but their results have been inconsistent.
|
24057253 |
2013 |