|
rs113488022
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In microsatellite stable tumors, homozygous carriers of the G39E polymorphism had an increased risk of CIMP+ colon cancer (odds ratio (OR) 2.2, 95% confidence interval (CI) 1.1, 4.2) and BRAF V600E mutation (OR 3.1, 95% CI 1.01, 9.7) in a case-control comparison.
|
19582761 |
2009 |
|
rs113488022
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer.
|
18519771 |
2008 |
|
rs113488022
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relationships between adenomatous polyposis coli (APC) mutations, BRAF V600E mutations, and the CpG island methylator phenotype (CIMP) in colon cancer have not been explored.
|
17293392 |
2007 |
|
rs113488022
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the role of BRAF activating mutation (BRAF-V600E) in colorectal tumourigenesis by studying the effects of forced expression of BRAF-V600E in the 'normal' colon epithelial NCM460 cell line and by targeting endogenous BRAF-V600E in MSI-High (MSI-H) colon cancer cell lines.
|
17427169 |
2007 |
|
rs113488022
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BRAF V600E mutation and 5 CpG island markers (MINT1, MINT2, MINT31, p16 and hMLH1) were assessed in 1154 cases of colon cancer.
|
17096326 |
2007 |
|
rs113488022
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the BRAF V600E mutation in microsatellite-stable colon cancer is associated with a significantly poorer survival in stages 2 to 4 colon cancer but has no effect on the excellent prognosis of microsatellite-unstable tumors.
|
16024606 |
2005 |
|
rs113488022
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, an oncogenic V600E hotspot mutation within BRAF, a kinase encoding gene from the RAS/RAF/MAPK pathway, has been found to be associated with sporadic MSI-H colon cancer, but its association with HNPCC remains to be further clarified.
|
15342696 |
2004 |
|
rs1217691063
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggests that MTHFR C677T polymorphism is associated with increased breast cancer, gastric cancer, and hepatocellular cancer risk in Asians, is associated with increased gastric cancer, multiple myeloma, and NHL risk in Caucasians, is associated with decreased AALL risk in Caucasians, is associated with decreased CALL risk in Asians, is associated with increased breast cancer risk in Asians, is associated with decreased colon cancer risk, and is associated with decreased colorectal cancer risk in male population.
|
26081619 |
2015 |
|
rs1217691063
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
An interaction was observed between the MTHFR C677T polymorphism and freshwater fish consumption on colon cancer risk (P value for interaction = 0.031).
|
20551579 |
2010 |
|
rs1217691063
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed.
|
20920350 |
2010 |
|
rs1217691063
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with a decreased risk of colon cancer although it may increase the risk of breast cancer.
|
19123462 |
2009 |
|
rs1217691063
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
(1) When men and women were assessed together, the frequencies of the MTHFR C677T and A1298 genotypes or their alleles were not significantly different between controls and co</span>lon cancer or rectal cancer cases.
|
18712959 |
2009 |
|
rs1217691063
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to be associated with childhood acute lymphoblastic leukemia (ALL), as well as colon cancer, lymphoma, esophageal and stomach cancer.
|
16886608 |
2006 |
|
rs1217691063
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Adequate intake of folate was a protective factor from colon cancer (OR=0.32, 95% CI: 0.12-0.88) and MTHFR C677T</span> polymorphism showed a statistically significant effect (OR=0.25, 95% CI: 0.06-0.93), reducing the risk of colon cancer in groups that have an intake of folate exceeding 115.64ng per 1000kcal per day.
|
15829374 |
2005 |
|
rs1217691063
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) 677C-->T polymorphism modifies the risk of coronary artery disease and colon cancer and is related to plasma concentrations of total homocysteine (tHcy).
|
15447919 |
2004 |
|
rs1217691063
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Using data from an incident case-control study (1608 cases and 1972 controls) we investigated two polymorphisms in the MTHFR gene, C677T and A1298C, and their associations with risk of colon cancer.
|
14973104 |
2004 |
|
rs1217691063
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and risk of proximal colon cancer in north Italy.
|
12576444 |
2003 |
|
rs1217691063
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR polymTHFR polymorphisms, especially the 677C-->T mutation, may contribute to vascular and birth defect risks, while reducing the risk of certain malignancies, such as colon cancer.
|
14633777 |
2003 |
|
rs121913377
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Immunohistochemistry with Anti-BRAF V600E (VE1) Mouse Monoclonal Antibody is a Sensitive Method for Detection of the BRAF V600E Mutation in Colon Cancer: Evaluation of 120 Cases with and without KRAS Mutation and Literature Review.
|
29127628 |
2019 |
|
rs121913377
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A colon cancer cell line with RNF43-G659Vfs*41 and BRAF-V600E mutations was sensitive to activation of Wnt/β-catenin signaling.
|
31811196 |
2019 |
|
rs121913377
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Long term response on Regorafenib in non-V600E BRAF mutated colon cancer: a case report.
|
31185985 |
2019 |
|
rs121913377
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results highlight the need to evaluate the action of glucocorticoid on cancer progression in melanoma, thyroid and colon carcinoma in which B-RAF-V600E is a frequent oncogene, and cancers in which evasion from senescence has been shown.
|
31371485 |
2019 |
|
rs121913377
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Vemurafenib is a B-Raf V600E inhibitor that exerts significant inhibitory effects in melanoma but not in colon cancer, and the mechanism of vemurafenib resistance remains unclear.
|
30872078 |
2019 |
|
rs121913377
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Colon carcinoma BRAF V600E HT29 cells exhibited poor response to radiation compared to BRAF wild-type COLO320 and HCT116 cells.
|
29663854 |
2018 |
|
rs121913377
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, the cluster drawn by the two mutations of V600E and E542K showed that all samples with those mutations belonged to the right-sided colon cancer group.
|
29556349 |
2018 |