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rs1800797
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|
Down Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigated the frequency of interleukin 6 polymorphisms (rs1800795, rs1800796, and rs1800797) in individuals with DS and individuals without the syndrome.
|
28829905 |
2017 |
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rs1800797
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriage of IL-6 rs1800796 G/G genotype, IL-6 rs1474358 C-allele, and IL-6 rs1800797 A-allele was more frequent in chronic HCV-infected patients than in HCC patients.
|
28340949 |
2017 |
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rs1800797
|
|
Malignant neoplasm of lung
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|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800797 was also associated with lung cancer among never smokers in the GENEVA dataset.
|
26372664 |
2016 |
|
rs1800797
|
|
Rheumatic Heart Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The IL-6 promoter rs1800797 (-597G/A) SNP may influence susceptibility to RHD of people of Māori and Pacific ancestry living in NZ.
|
27400406 |
2016 |
|
rs1800797
|
|
Adult onset asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL6 SNP rs1800797 associated with the risk of adult-onset asthma in a log additive model, with adjusted odds ratio (aOR) 1.31 (95% confidence interval 1.09-1.57), and especially with the risk of atopic adult-onset asthma when compared with non-atopic controls, aOR 1.46 (95% CI 1.12-1.90).
|
26938664 |
2016 |
|
rs1800797
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800797 was also associated with lung cancer among never smokers in the GENEVA dataset.
|
26372664 |
2016 |
|
rs1800797
|
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our preliminary findings are suggestive of an association between rs1800797 and the risk of MDD.
|
27502736 |
2016 |
|
rs1800797
|
|
CATARACT, ANTERIOR POLAR
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CRP +1846C/T (rs1205), IL-6 -597G/A (rs1800797), and IL-10 -592C/A (rs1800872) may be associated with the susceptibility and severity of CAP.
|
27705004 |
2016 |
|
rs1800797
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800797 was also associated with lung cancer among never smokers in the GENEVA dataset.
|
26372664 |
2016 |
|
rs1800797
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study suggested that this risk model could identify patients at high risk of SR aGVHD with donor genotype of IL6 (rs1800797) and IFNG (rs2069727) along with gastrointestinal involvement of aGVHD.
|
25774595 |
2015 |
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rs1800797
|
|
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression.
|
25962811 |
2015 |
|
rs1800797
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interleukin-6 (IL-6)-597 A/G (rs1800797) & -174 G/C (rs1800795) gene polymorphisms in type 2 diabetes.
|
25222779 |
2014 |
|
rs1800797
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population.
|
25299085 |
2014 |
|
rs1800797
|
|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
AA genotype in rs1800797 of IL-6 was associated with the increased risk of developing AR.
|
24974143 |
2014 |
|
rs1800797
|
|
Hodgkin Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The IL-6 promoter rs1800795 and rs1800797 were not associated with overall susceptibility to non-Hodgkin's lymphomas.
|
24059848 |
2013 |
|
rs1800797
|
|
Leprosy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant associations (P < .05) were observed for 8 polymorphisms (rs1800871, rs1800872, and rs1554286 of IL-10; rs3171425 and rs7281762 of IL-10RB; rs2228048 and rs744751 of TGFBR2; and rs1800797 of IL-6) with leprosy.
|
21917900 |
2011 |
|
rs1800797
|
|
Delirium
|
|
0.010 |
GeneticVariation
|
BEFREE |
Rs1800697 and rs1800797 in the IL6 gene, rs8192284 in the IL6R gene, and rs4073 in the IL8 gene were not associated with the development of delirium.
|
21851175 |
2011 |
|
rs1800797
|
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
Possession of the IL-6 rs1800797 GG genotype by the LTA and TNF-alpha risk genotype carriers further increased risk of the MetS [OR 2.10 (CI 1.19-3.71) P = 0.009], fasting hyperglycemia [OR 2.65 (CI 1.12-6.28), P = 0.027], high systolic blood pressure [OR 1.99 (CI 1.07-3.72), P = 0.03], and abdominal obesity [OR 1.52 (CI 1.01-2.28), P = 0.04].
|
20080841 |
2010 |
|
rs1800797
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The most significant finding (nominal P = 0.0004; false discovery rate q = 0.037) was a combined genotype association across IKBKB SNP rs5029748 (1 or 2 variant alleles), IL6 rs1800797 (1 or 2 variant alleles), and NFKB1 rs4648110 (2 variant alleles) which conferred an ~80% decreased risk of colon cancer.
|
21129206 |
2010 |
|
rs1800797
|
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
The most significant finding (nominal P = 0.0004; false discovery rate q = 0.037) was a combined genotype association across IKBKB SNP rs5029748 (1 or 2 variant alleles), IL6 rs1800797 (1 or 2 variant alleles), and NFKB1 rs4648110 (2 variant alleles) which conferred an ~80% decreased risk of colon cancer.
|
21129206 |
2010 |
|
rs1800797
|
|
Hyperglycemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Possession of the IL-6 rs1800797 GG genotype by the LTA and TNF-alpha risk genotype carriers further increased risk of the MetS [OR 2.10 (CI 1.19-3.71) P = 0.009], fasting hyperglycemia [OR 2.65 (CI 1.12-6.28), P = 0.027], high systolic blood pressure [OR 1.99 (CI 1.07-3.72), P = 0.03], and abdominal obesity [OR 1.52 (CI 1.01-2.28), P = 0.04].
|
20080841 |
2010 |
|
rs1800797
|
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele.
|
19585495 |
2009 |
|
rs1800797
|
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele.
|
19585495 |
2009 |
|
rs1800797
|
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele.
|
19585495 |
2009 |