Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 140821
Gene Symbol: RSS
RSS
0.030 Biomarker phenotype BEFREE Demographics, alignment, and SRS-Schwab modifiers were assessed with χ/paired t tests to compare HRQLs: Scoliosis Research Society 22-question Questionnaire (SRS-22), Numeric Rating Scale (NRS) Back/Leg Pain, Oswestry Disability Index (ODI). 31651683 2020
Entrez Id: 55906
Gene Symbol: ZC4H2
ZC4H2
0.030 Biomarker phenotype BEFREE PROMs analyzed were the Short Form-12 Physical Component Score (PCS-12), Mental Component Score (MCS-12), Oswestry Disability Index (ODI), and Visual Analog Scale (VAS) Back and Leg pain scores. 31770335 2020
Entrez Id: 6611
Gene Symbol: SMS
SMS
0.030 Biomarker phenotype BEFREE Demographics, alignment, and SRS-Schwab modifiers were assessed with χ/paired t tests to compare HRQLs: Scoliosis Research Society 22-question Questionnaire (SRS-22), Numeric Rating Scale (NRS) Back/Leg Pain, Oswestry Disability Index (ODI). 31651683 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.030 Biomarker phenotype BEFREE In this cohort, no significant differences in serum levels of TNFα, IL-6 or any other biomarkers were seen between patients with sciatica and those with back pain with referred leg pain. 31077179 2019
Entrez Id: 7584
Gene Symbol: ZNF35
ZNF35
0.030 Biomarker phenotype BEFREE High-frequency spinal cord stimulation at 10 kHz (HF10-SCS) has been demonstrated to provide enhanced and durable pain relief in patients with chronic back and radiating leg pain. 30365222 2019
Entrez Id: 140821
Gene Symbol: RSS
RSS
0.030 Biomarker phenotype BEFREE Perioperative spinal deformity parameters, complications, and HRQoL outcome scores (Oswestry Disability Index [ODI], Scoliosis Research Society 22-question Questionnaire [SRS-22], 36-Item Short Form Health Survey [SF-36], visual analog scale [VAS] for back/leg pain) from each group were assessed and compared with each other using ANOVA. 29087808 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.030 AlteredExpression phenotype BEFREE Acute exercise in children with JIA induced slightly musculoskeletal leg pain and transient increased plasma calprotectin levels but not IL-6 levels. 30008613 2018
Entrez Id: 6611
Gene Symbol: SMS
SMS
0.030 Biomarker phenotype BEFREE HRQOL questionnaires included the Oswestry Disability Index (ODI), Scoliosis Research Society (SRS-22r), 36-item Short-Form Health Survey, and numeric rating scale (NRS) for back and leg pain. 29570046 2018
Entrez Id: 6611
Gene Symbol: SMS
SMS
0.030 Biomarker phenotype BEFREE Perioperative spinal deformity parameters, complications, and HRQoL outcome scores (Oswestry Disability Index [ODI], Scoliosis Research Society 22-question Questionnaire [SRS-22], 36-Item Short Form Health Survey [SF-36], visual analog scale [VAS] for back/leg pain) from each group were assessed and compared with each other using ANOVA. 29087808 2018
Entrez Id: 140821
Gene Symbol: RSS
RSS
0.030 Biomarker phenotype BEFREE HRQOL questionnaires included the Oswestry Disability Index (ODI), Scoliosis Research Society (SRS-22r), 36-item Short-Form Health Survey, and numeric rating scale (NRS) for back and leg pain. 29570046 2018
Entrez Id: 4184
Gene Symbol: SMCP
SMCP
0.030 GeneticVariation phenotype BEFREE Preoperatively to 12-month follow-up there were increases in segmental lordosis (7.9-9.4 degrees, P=0.0497), lumbar lordosis (48.8-55.2 degrees, P=0.0328), and disk height (3.7-5.5 mm, P=0.0018); there were also improvements in back (58.6%) and leg pain (60.0%), ODI (44.4%), PCS (56.7%), and MCS (16.1%) for stand-alone XLIF. 28207620 2017
Entrez Id: 55034
Gene Symbol: MOCOS
MOCOS
0.030 GeneticVariation phenotype BEFREE Preoperatively to 12-month follow-up there were increases in segmental lordosis (7.9-9.4 degrees, P=0.0497), lumbar lordosis (48.8-55.2 degrees, P=0.0328), and disk height (3.7-5.5 mm, P=0.0018); there were also improvements in back (58.6%) and leg pain (60.0%), ODI (44.4%), PCS (56.7%), and MCS (16.1%) for stand-alone XLIF. 28207620 2017
Entrez Id: 4184
Gene Symbol: SMCP
SMCP
0.030 GeneticVariation phenotype BEFREE Clinical outcomes included back and leg pain, Oswestry Disability Index (ODI), and SF-36 physical and mental component scores (PCS and MCS). 28028645 2017
Entrez Id: 7584
Gene Symbol: ZNF35
ZNF35
0.030 Biomarker phenotype BEFREE Patients with both back and leg pain already implanted with an HF10 therapy device for up to 24 months were included in this multicenter study. 28535555 2017
Entrez Id: 55034
Gene Symbol: MOCOS
MOCOS
0.030 GeneticVariation phenotype BEFREE Clinical outcomes included back and leg pain, Oswestry Disability Index (ODI), and SF-36 physical and mental component scores (PCS and MCS). 28028645 2017
Entrez Id: 7584
Gene Symbol: ZNF35
ZNF35
0.030 Biomarker phenotype BEFREE Recent FDA approval and superiority of the Nevro Senza 10-kHz high frequency (HF10) spinal cord stimulation (SCS) therapy over traditional low-frequency spinal cord stimulation for treatment of chronic back and leg pain may provide a new interventional therapeutic option for patients suffering from CRPS. 28072810 2017
Entrez Id: 55906
Gene Symbol: ZC4H2
ZC4H2
0.030 GeneticVariation phenotype BEFREE Clinical outcomes included back and leg pain, Oswestry Disability Index (ODI), and SF-36 physical and mental component scores (PCS and MCS). 28028645 2017
Entrez Id: 55906
Gene Symbol: ZC4H2
ZC4H2
0.030 GeneticVariation phenotype BEFREE Preoperatively to 12-month follow-up there were increases in segmental lordosis (7.9-9.4 degrees, P=0.0497), lumbar lordosis (48.8-55.2 degrees, P=0.0328), and disk height (3.7-5.5 mm, P=0.0018); there were also improvements in back (58.6%) and leg pain (60.0%), ODI (44.4%), PCS (56.7%), and MCS (16.1%) for stand-alone XLIF. 28207620 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.030 GeneticVariation phenotype BEFREE An interaction between the IL6 haplotype and physical work load was significant for the duration of back and leg pain and sick leave (p=0.038, 0.011 and 0.006, respectively). 18321738 2008
Entrez Id: 3929
Gene Symbol: LBP
LBP
0.020 Biomarker phenotype BEFREE Decompression surgery can improve low back pain, regardless of the degree of preoperative leg pain, but the average score for LBP and leg pain slightly worsened between 3 months and 1 year after surgery. 31473813 2020
Entrez Id: 412
Gene Symbol: STS
STS
0.020 GeneticVariation phenotype BEFREE The association of MBP and MLP with 5R-STS test times as well as with the presence of OFI (> 10.5 s) and severe OFI (> 22.0 s) as determined by the 5R-STS baseline severity stratification was quantified by use of crude and adjusted regression models.A total of 258 patients were included. 31451936 2019
Entrez Id: 412
Gene Symbol: STS
STS
0.020 Biomarker phenotype BEFREE The 5R-STS test showed no correlation with VAS for leg pain and EQ-5D VAS (p > 0.05). 29957147 2018
Entrez Id: 3929
Gene Symbol: LBP
LBP
0.020 Biomarker phenotype BEFREE Cumulative risks of both leg pain and LBP recurrence were generally lower in participants achieving complete initial resolution of pain post-discectomy. 27584678 2017
Entrez Id: 4210
Gene Symbol: MEFV
MEFV
0.010 GeneticVariation phenotype BEFREE Headaches and exertional leg pain were associated with MEFV gene mutations (P < 0.05). 31682063 2019
Entrez Id: 7291
Gene Symbol: TWIST1
TWIST1
0.010 GeneticVariation phenotype BEFREE Patient-reported back and leg pain using the visual analog scale (VAS) and opioid dose (milligrams morphine equivalent/day, MME/day) were compared at 12 months post-10 kHz SCS therapy to baseline. 31391503 2019