Source: CURATED ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.570 Therapeutic disease CTD_human Nuclear erythroid 2-related factor 2: a novel potential therapeutic target for liver fibrosis. 23793039 2013
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.560 Biomarker disease CTD_human Inhibition of cGMP-specific phosphodiesterase type 5 reduces sodium excretion and arterial blood pressure in patients with NaCl retention and ascites. 15613622 2005
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		0.510 Biomarker disease CTD_human Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. 26396155 2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		0.510 Biomarker disease CTD_human Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. 15763341 2005
Entrez Id: 2321
Gene Symbol: FLT1
FLT1 		0.510 Biomarker disease CTD_human Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. 11981751 2002
Entrez Id: 2200
Gene Symbol: FBN1
FBN1 		0.500 Biomarker disease CTD_human Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. 26396155 2016
Entrez Id: 210
Gene Symbol: ALAD
ALAD 		0.500 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
Entrez Id: 540
Gene Symbol: ATP7B
ATP7B 		0.410 Biomarker disease CTD_human Wilson disease (WD) is caused by accumulation of excess copper (Cu) due to a mutation in the gene encoding the liver Cu transporter ATP7B, and is characterized by acute liver failure or cirrhosis and neuronal cell death. 25134866 2014
Entrez Id: 3959
Gene Symbol: LGALS3BP
LGALS3BP 		0.400 Biomarker disease CTD_human Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. 26396155 2016
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1 		0.400 Biomarker disease CTD_human AAT deficiency is a genetic disease that manifests with emphysema and liver cirrhosis due to the accumulation of a misfolded AAT mutant in hepatocytes. 25579632 2015
Entrez Id: 213
Gene Symbol: ALB
ALB 		0.400 Biomarker disease CTD_human This study aimed to assess IMA and IMAR as a liver function test and to investigate whether albumin infusion changes IMAR in patients with liver cirrhosis. 21851314 2011
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1 		0.400 Biomarker disease CTD_human Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model. 20511674 2010
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.400 Biomarker disease CTD_human The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis. 21037076 2010
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1 		0.400 Therapeutic disease CTD_human These results suggest that IFN-alpha gene therapy is a promising strategy to treat HCC patients who have concomitant liver cirrhosis. 18665156 2008
Entrez Id: 213
Gene Symbol: ALB
ALB 		0.400 Biomarker disease CTD_human [Apolipoprotein A in patients with alcoholic liver disease]. 17977396 2008
Entrez Id: 3082
Gene Symbol: HGF
HGF 		0.400 Therapeutic disease CTD_human Effects of hepatotrophic factors on the liver after portacaval shunt in rats with portal hypertension. 17097021 2006
Entrez Id: 5972
Gene Symbol: REN
REN 		0.400 Biomarker disease CTD_human In patients with ascites and cirrhosis, inhibition of PDE5 did not promote natriuresis but led to increased plasma levels of the renin-angiotensin-aldosterone system. 15613622 2005
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.400 Biomarker disease CTD_human Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases. 12830005 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.400 Biomarker disease CTD_human Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. 11981751 2002
Entrez Id: 2147
Gene Symbol: F2
F2 		0.400 Biomarker disease CTD_human Vitamin E reduces monocyte tissue factor expression in cirrhotic patients. 10216089 1999
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1 		0.400 Biomarker disease CTD_human We conclude that men with alpha 1-antitrypsin deficiency may be at higher risk for cirrhosis and primary liver cancer. 3485248 1986
Entrez Id: 929
Gene Symbol: CD14
CD14 		0.390 Biomarker disease CTD_human Elevated endotoxin levels in non-alcoholic fatty liver disease. 20353583 2010
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.380 Biomarker disease CTD_human Tumor formation in liver of conditional β-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen. 21047994 2011
Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4 		0.360 Biomarker disease CTD_human Integrin beta6 mRNA increased with fibrosis stage in hepatitis C and was upregulated between 25- and 100-fold in TAA- and BDL-induced cirrhosis, in Mdr2(Abcb4)(-/-) mice and in human end-stage liver disease. alphavbeta6 protein was absent in normal livers and expressed de novo on (activated) bile duct epithelia and transitional hepatocytes. 18221819 2008
Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4 		0.360 Biomarker disease CTD_human Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene. 8698195 1996