Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1628
Gene Symbol: DBP
DBP 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries; PCO: polycystic ovary; PCOS: polycystic ovary syndrome; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP: systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D. 30958034 2019
Entrez Id: 6822
Gene Symbol: SULT2A1
SULT2A1 		0.020 Biomarker disease BEFREE <b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries; PCO: polycystic ovary; PCOS: polycystic ovary syndrome; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP: systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D. 30958034 2019
Entrez Id: 6046
Gene Symbol: BRD2
BRD2 		0.050 Biomarker disease BEFREE <b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries; PCO: polycystic ovary; PCOS: polycystic ovary syndrome; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP: systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D. 30958034 2019
Entrez Id: 6462
Gene Symbol: SHBG
SHBG 		0.100 Biomarker disease BEFREE <b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries; PCO: polycystic ovary; PCOS: polycystic ovary syndrome; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP: systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D. 30958034 2019
Entrez Id: 5120
Gene Symbol: PCOS1
PCOS1 		0.020 Biomarker disease BEFREE <b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries; PCO: polycystic ovary; PCOS: polycystic ovary syndrome; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP: systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D. 30958034 2019
Entrez Id: 54535
Gene Symbol: CCHCR1
CCHCR1 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries; PCO: polycystic ovary; PCOS: polycystic ovary syndrome; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP: systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D. 30958034 2019
Entrez Id: 8991
Gene Symbol: SELENBP1
SELENBP1 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: AUC: area under curve; BMI: body mass index; C: cholesterol; CI: confidence interval; DBP: diastolic blood pressure; DHEAS: dehydroepiandrosterone sulfate; FG: Ferriman-Gallway; FSH: follicle stimulating hormone; GHQ: general health questionnaire; HA: hyperandrogenism; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostatic model assessment for insulin resistance; HWR: hip waist ratio; LDL-C: low-density lipoprotein cholesterol; LH: luteinizing hormone; LH: luteinizing hormone; LHR: lutropin receptor; O: oligomenorrhea; OR: odds ratio; PCO: polycystic ovaries; PCO: polycystic ovary; PCOS: polycystic ovary syndrome; PCR: polymerase chain reaction; ROC: receiver operating curve; SBP: systolic blood pressure; SE: standard error of coefficient; SNP: single nucleotide polymorphism; TG: triglycerides; TSH: thyroid stimulating hormone; VD: vitamin D. 30958034 2019
Entrez Id: 366
Gene Symbol: AQP9
AQP9 		0.010 Biomarker disease BEFREE Hyperandrogenism in FF of women with PCOS inhibited AQP-9 in GCs through the PI3K pathway. 20378617 2010
Entrez Id: 367
Gene Symbol: AR
AR 		0.080 GeneticVariation disease BEFREE Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism. 12843184 2003
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.030 Biomarker disease BEFREE Interleukin-6 (IL-6), is an inflammatory cytokine that may influence the pathogenesis of obesity and hyperandrogenism. 12917504 2003
Entrez Id: 3640
Gene Symbol: INSL3
INSL3 		0.010 Biomarker disease LHGDN INSL3 could be considered a new circulating hormone related to LH-dependent ovarian hyperandrogenism, particularly in normal-weight PCOS women. 17356050 2007
Entrez Id: 2492
Gene Symbol: FSHR
FSHR 		0.010 GeneticVariation disease BEFREE FSHR Ser(680) was associated with higher levels of gonadotrophic hormones (FSH: P < 0.01, LH: P = 0.01), and testosterone (P = 0.05) and a higher frequency of hyperandrogenism (P = 0.04). 19403562 2009
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.020 AlteredExpression disease BEFREE Adiponectin gene polymorphisms were not associated with the anthropometric parameters, hyperandrogenism and adiponectin levels in PCOS. 20388053 2010
Entrez Id: 6662
Gene Symbol: SOX9
SOX9 		0.010 AlteredExpression disease BEFREE SOX9 was expressed in the granulosa cell nucleus in 2/6 cases but also in 9/24 tumors without hyperandrogenism (p=n.s.). 20395670 2010
Entrez Id: 668
Gene Symbol: FOXL2
FOXL2 		0.010 Biomarker disease BEFREE FOXL2 was absent or decreased in 3/6 cases of JGCTO with hyperandrogenism with no statistical difference from the group without this symptom. 20395670 2010
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.240 Biomarker disease RGD Peroxisome proliferator-activated receptor gamma and early folliculogenesis during an acute hyperandrogenism condition. 20813360 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.240 Biomarker disease BEFREE PPARγ are receptors that are probably involved in hyperandrogenism. 21827375 2012
Entrez Id: 2353
Gene Symbol: FOS
FOS 		0.010 Biomarker disease BEFREE FOS dysfunction may be a common factor between hyperandrogenism and insulin resistance. 22723319 2012
Entrez Id: 268
Gene Symbol: AMH
AMH 		0.090 Biomarker disease BEFREE AMH was cross-sectionally and longitudinally related to hyperandrogenism. 28432801 2017
Entrez Id: 4880
Gene Symbol: NPPC
NPPC 		0.010 Biomarker disease BEFREE C-type natriuretic peptide: a link between hyperandrogenism and anovulation in a mouse model of polycystic ovary syndrome. 29739821 2018
Entrez Id: 1393
Gene Symbol: CRHBP
CRHBP 		0.010 AlteredExpression disease BEFREE Corticotropin releasing hormone binding protein is consistently the up-regulated lncRNA with the highest fold-change in PCOS-T compared with either control or PCOS-N. Gene ontology and pathway analysis showed that dysregulated lncRNA in PCOS-T have a regulatory role in mitochondrial function by interacting with transcription factors such as YY1 and SIX5. 30224242 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.050 Biomarker disease BEFREE TNF α, pro-inflammatory cytokine is associated with obesity, insulin resistance and hyperandrogenism, therefore in present study we tried to find the association between TNF α promoter polymorphisms, TNF α levels and the risk of PCOS. 30442458 2019
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.060 Biomarker disease BEFREE POMC has also been identified as one of the candidate loci for polycystic ovary syndrome (PCOS) which features hyperandrogenism and some prevalence of obesity in patients. 31237951 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.080 GeneticVariation disease BEFREE A novel insulin receptor mutation in an adolescent with acanthosis nigricans and hyperandrogenism. 27505086 2016
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2 		0.310 Biomarker disease BEFREE A positive correlation was found between BMPR2 transcripts and hyperandrogenism in FF of PCOS patients. 22825968 2012