Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1 		0.500 Biomarker disease CTD_human Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression. 27525872 2016
Entrez Id: 2920
Gene Symbol: CXCL2
CXCL2 		0.500 Biomarker disease CTD_human Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression. 27525872 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.500 Therapeutic disease CTD_human Troglitazone-activated PPARγ inhibits LPS-induced lung alveolar type II epithelial cells injuries via TNF-α. 21153920 2011
Entrez Id: 7432
Gene Symbol: VIP
VIP 		0.500 Biomarker disease RGD The present study was conducted to investigate the effects of VIP on TLR2/4 mRNA expressions on acute lung injury of endotoxic shock induced by lipopolysaccharide (LPS) in rat. 20441697 2010
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1 		0.500 Therapeutic disease RGD Pentoxifylline inhibits intercellular adhesion molecule-1 (ICAM-1) and lung injury in experimental phosgene-exposure rats. 20569121 2010
Entrez Id: 2920
Gene Symbol: CXCL2
CXCL2 		0.500 Biomarker disease RGD Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent. 19106808 2009
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1 		0.500 Biomarker disease CTD_human Intercellular adhesion molecule-1 (ICAM-1) is involved in neutrophil transmigration across endothelium during sepsis-induced acute lung injury and anti-ICAM-1 interventions may represent new strategy of pulmonary protection. 17973899 2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.500 Biomarker disease RGD Decreased expression of peroxisome proliferator-activated receptor gamma in endotoxin-induced acute lung injury. 16083301 2006
Entrez Id: 7432
Gene Symbol: VIP
VIP 		0.500 Therapeutic disease CTD_human Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase. 8643465 1996
Entrez Id: 6441
Gene Symbol: SFTPD
SFTPD 		0.300 Therapeutic disease CTD_human Protective Role of Surfactant Protein-D Against Lung Injury and Oxidative Stress Induced by Nitrogen Mustard. 30060251 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.300 Biomarker disease CTD_human IL-17A involves the ALI induced by LPS or PQ and promotes the pathological process by activating NF-κB P65 and recruiting neutrophils, which enlarges the cascade effect of inflammation and injures lung tissues. 28600744 2017
Entrez Id: 2052
Gene Symbol: EPHX1
EPHX1 		0.300 Biomarker disease CTD_human Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice. 26840748 2016
Entrez Id: 7130
Gene Symbol: TNFAIP6
TNFAIP6 		0.300 Therapeutic disease CTD_human The study was aimed to explore the effects of tumor necrosis factor-α (TNF-α) induced protein 6 (TSG-6) on acute lung injury (ALI) following paraquat exposure in rats. 26313688 2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.300 Therapeutic disease CTD_human Mifepristone-inducible recombinant adenovirus attenuates paraquat-induced lung injury in rats. 24812154 2015
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1 		0.300 Therapeutic disease CTD_human Adenovirus-mediated overexpression of soluble ST2 provides a protective effect on lipopolysaccharide-induced acute lung injury in mice. 21352201 2011
Entrez Id: 335
Gene Symbol: APOA1
APOA1 		0.300 Therapeutic disease CTD_human Down-regulation of endothelial TLR4 signalling after apo A-I gene transfer contributes to improved survival in an experimental model of lipopolysaccharide-induced inflammation. 20972769 2011
Entrez Id: 90
Gene Symbol: ACVR1
ACVR1 		0.300 Biomarker disease CTD_human This approach identified several candidate genes, including Acvr1, associated with increased susceptibility to acute lung injury in mice. 21297076 2011
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1 		0.300 Therapeutic disease CTD_human Achaete-scute homologue-1 tapers neuroendocrine cell differentiation in lungs after exposure to naphthalene. 20554700 2010
Entrez Id: 7031
Gene Symbol: TFF1
TFF1 		0.300 Biomarker disease CTD_human Airway trefoil factor expression during naphthalene injury and repair. 19880587 2010
Entrez Id: 7032
Gene Symbol: TFF2
TFF2 		0.300 Biomarker disease CTD_human Airway trefoil factor expression during naphthalene injury and repair. 19880587 2010
Entrez Id: 4638
Gene Symbol: MYLK
MYLK 		0.300 Biomarker disease CTD_human The results suggest that MLCK has a crucial role in the pathogenesis of ALI. 19374788 2009
Entrez Id: 1906
Gene Symbol: EDN1
EDN1 		0.300 Biomarker disease CTD_human Effects of endothelin receptor antagonism on acute lung injury induced by chlorine gas. 16625121 2006
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.300 Biomarker disease CTD_human Gene expression changes during the development of acute lung injury: role of transforming growth factor beta. 16100012 2005
Entrez Id: 7295
Gene Symbol: TXN
TXN 		0.300 Therapeutic disease CTD_human Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced downregulation of Akt. 16298680 2005
Entrez Id: 847
Gene Symbol: CAT
CAT 		0.300 Therapeutic disease CTD_human Effects of various antioxidants on endotoxin-induced lung injury and gene expression: mRNA expressions of MnSOD, interleukin-1beta and iNOS. 15612528 2004