Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.010 Biomarker phenotype BEFREE We hypothesized that P-glycoprotein is involved in the physiologic maintenance of early pregnancy and that P-glycoprotein dysregulation may be involved in early pregnancy pathologies. 31126216 2019
Entrez Id: 27034
Gene Symbol: ACAD8
ACAD8
0.010 Biomarker phenotype BEFREE Microbial diversity in pregnant patients with IBD was reduced compared with that in healthy women, and significant differences existed between patients with UC and CD in early pregnancy. 31167813 2020
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.010 Biomarker phenotype BEFREE TC-derived CXCL12 promoted the migration and invasion of DECs via CXCR4, but not CXCR7, in a paracrine manner during early pregnancy. 29499763 2018
Entrez Id: 10149
Gene Symbol: ADGRG2
ADGRG2
0.010 AlteredExpression phenotype BEFREE In the present study, immunohistochemical analysis reveals a spatiotemporal expression of GPR64 in the uterus during early pregnancy. 28694502 2017
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.030 Biomarker phenotype BEFREE Therefore, we investigated the effects of parity on expression of ADIPOR1 and ADIPOR2 and the effects of adiponectin in the porcine endometrium during early pregnancy. 28063235 2017
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.030 AlteredExpression phenotype BEFREE Both PGE<sub>2</sub> and PGF<sub>2α</sub> modulated the expression of adiponectin system genes and proteins in the uterus during early pregnancy. 27938627 2017
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.030 Biomarker phenotype BEFREE We sought to examine associations of leptin and adiponectin to insulin sensitivity already at early pregnancy before recommended screening for GDM and to describe trajectories of adiponectin in relation to GDM status. 30123262 2018
Entrez Id: 51094
Gene Symbol: ADIPOR1
ADIPOR1
0.010 AlteredExpression phenotype BEFREE Results of this study revealed robust expression of ADIPOR1 and ADIPOR2 in uterine luminal (LE) and glandular (GE) epithelia during early pregnancy and expression decreased as with increasing parity. 28063235 2017
Entrez Id: 79602
Gene Symbol: ADIPOR2
ADIPOR2
0.010 AlteredExpression phenotype BEFREE Results of this study revealed robust expression of ADIPOR1 and ADIPOR2 in uterine luminal (LE) and glandular (GE) epithelia during early pregnancy and expression decreased as with increasing parity. 28063235 2017
Entrez Id: 174
Gene Symbol: AFP
AFP
0.010 AlteredExpression phenotype BEFREE Alpha-fetoprotein (A.F.P,) levels were found to ge significantly raised in maternal serum and amniotic-fluid samples form the 16th and 18th weeks of gestation in a woman with an apparently normal fetus but with histological evidence of congenital nephrosis of the Finnish type.Increased concentrations of A.F.P. in early pregnancy with a living fetus are therefore not specific for neural-tube defects; More likely they result from the fetal circulation. 48616 1975
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.010 AlteredExpression phenotype BEFREE This study was undertaken to examine changes in the levels of angiogenic factors and angiotensin II type 1 receptor autoantibodies (AT1-AAs) throughout gestation, from early pregnancy until delivery, in women with PE and to examine their association with cord angiogenic factors, blood pressure and infant weight. 24718301 2014
Entrez Id: 196
Gene Symbol: AHR
AHR
0.010 Biomarker phenotype BEFREE Recent studies have demonstrated that the aryl hydrocarbon receptor (AhR) might play important roles in establishing and maintaining early pregnancy. 26593447 2016
Entrez Id: 268
Gene Symbol: AMH
AMH
0.020 Biomarker phenotype BEFREE We propose that the lack of Müllerian structures is caused by the effect of the Müllerian inhibiting substance transferred from the male to the female twin in early pregnancy. 20190264 2010
Entrez Id: 268
Gene Symbol: AMH
AMH
0.020 Biomarker phenotype BEFREE Tight interplay in early pregnancy between follistatin and anti-mullerian hormone in women with polycystic ovarian syndrome (PCOS). 29453653 2018
Entrez Id: 284
Gene Symbol: ANGPT1
ANGPT1
0.010 AlteredExpression phenotype BEFREE Serum and tissue mRNA determination of ANG-1 and ANG-2 levels by ELISA and RTPCR, from 60 (30 EP and 30 MA) patients with failed early pregnancy and 33 IUPs. 23099117 2013
Entrez Id: 285
Gene Symbol: ANGPT2
ANGPT2
0.010 AlteredExpression phenotype BEFREE Serum and tissue mRNA determination of ANG-1 and ANG-2 levels by ELISA and RTPCR, from 60 (30 EP and 30 MA) patients with failed early pregnancy and 33 IUPs. 23099117 2013
Entrez Id: 55908
Gene Symbol: ANGPTL8
ANGPTL8
0.010 Biomarker phenotype BEFREE The present study aimed to determine whether the concentration of angiopoietin-like protein 8 (ANGPTL8), either alone or combined with other risk factors in early pregnancy, could be used to predict subsequent GDM. 29167926 2018
Entrez Id: 55107
Gene Symbol: ANO1
ANO1
0.010 AlteredExpression phenotype BEFREE In this study, we focused on the expression and regulation of TMEM16A in mouse uterus during early pregnancy. 30328351 2018
Entrez Id: 301
Gene Symbol: ANXA1
ANXA1
0.010 Biomarker phenotype BEFREE In summary, herein we highlight that AnxA1 pathway as a novel determinant of fundamental non-redundant regulatory functions during early pregnancy. 29115663 2018
Entrez Id: 308
Gene Symbol: ANXA5
ANXA5
0.010 GeneticVariation phenotype BEFREE This study cautions to consider the M2 haplotype as a deterministic factor in early pregnancy success because: i) no RPL disease risk was associated with the haplotype in two clinically well-characterized RPL case-control study samples, ii) high prevalence of the haplotype among fertile controls and world-wide populations is inconsistent with the previously proposed severe impact on early pregnancy success, iii) weak impact of M2 haplotype on the production of ANXA5 protein has been established by others. 26135579 2015
Entrez Id: 361
Gene Symbol: AQP4
AQP4
0.010 AlteredExpression phenotype BEFREE Aquaporin-4 (AQP4), the most common target antigen in NMOSD, is expressed on placenta in early pregnancy. 29154728 2017
Entrez Id: 8289
Gene Symbol: ARID1A
ARID1A
0.020 AlteredExpression phenotype BEFREE In the present study, we performed real-time qPCR and immunohistochemistry analysis to investigate the regulation of PIK3IP1 by ARID1A and determine expression patterns of PIK3IP1 in the uterus during early pregnancy. 29289536 2018
Entrez Id: 8289
Gene Symbol: ARID1A
ARID1A
0.020 Biomarker phenotype BEFREE ARID1A Is Essential for Endometrial Function during Early Pregnancy. 26378916 2015
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.030 Biomarker phenotype BEFREE Expression of mmu-miR-96 in the endometrium during early pregnancy and its regulatory effects on stromal cell apoptosis via Bcl2. 28259902 2017
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.030 AlteredExpression phenotype BEFREE Western blot analyses revealed that Bcl-2 expression was significantly lower in the regressing CL than in the midluteal phase and early pregnancy, and that Bax expression was, in contrast, significantly higher in the regressing CL than in the midluteal phase and was remarkably low in the CL of early pregnancy. 11095483 2000