Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 367
Gene Symbol: AR
AR 		0.320 GeneticVariation phenotype BEFREE Non-linear association between androgen receptor CAG repeat length and risk of male subfertility--a meta-analysis. 20579136 2011
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		0.310 GeneticVariation phenotype BEFREE The data suggest that the C677T MTHFR polymorphism is not a risk factor for idiopathic male subfertility in an Algerian population. 22928696 2012
Entrez Id: 4968
Gene Symbol: OGG1
OGG1 		0.310 GeneticVariation phenotype BEFREE To investigate the association between the human 8-oxoguanine DNA glycosylase 1 (hOGG1) gene Ser326Cys polymorphism and male subfertility in Taiwanese patients with varicocele, we made a prospective study. 29582449 2018
Entrez Id: 1811
Gene Symbol: SLC26A3
SLC26A3 		0.040 GeneticVariation phenotype BEFREE Homozygous SLC26A3 mutations cause congenital chloride diarrhea with male subfertility, while homozygous CFTR mutations cause cystic fibrosis with male infertility. 29079751 2017
Entrez Id: 339168
Gene Symbol: TMEM95
TMEM95 		0.010 GeneticVariation phenotype BEFREE A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle. 24391514 2014
Entrez Id: 1760
Gene Symbol: DMPK
DMPK 		0.010 GeneticVariation phenotype BEFREE The number of CTG repeats in the normal or mutational range of DM1PK gene is associated with neither idiopathic male subfertility nor with clinical characteristics of male subfertility. 15284213 2004
Entrez Id: 122664
Gene Symbol: TPPP2
TPPP2 		0.010 GeneticVariation phenotype BEFREE Studies on Tppp2 knockout (KO) mice demonstrated that deletion of TPPP2 resulted in male subfertility with a significantly decreased sperm count and motility. 30680919 2019
Entrez Id: 8755
Gene Symbol: ADAM6
ADAM6 		0.010 GeneticVariation phenotype BEFREE Deletion of Adam6 in Mus musculus leads to male subfertility and deficits in sperm ascent into the oviduct. 30289441 2019
Entrez Id: 6103
Gene Symbol: RPGR
RPGR 		0.010 GeneticVariation phenotype BEFREE Rarely, RPGR mutations can also cause primary ciliary dyskinesia (PCD), a multisystem disorder characterized by recurrent respiratory tract infections, sinusitis, bronchiectasis, and male subfertility. 22888088 2013
Entrez Id: 81623
Gene Symbol: DEFB126
DEFB126 		0.010 GeneticVariation phenotype BEFREE DEFB126 was reported to contribute to the sialylation on sperm surface and its homozygous mutation was related to male subfertility. 26832966 2016
Entrez Id: 83844
Gene Symbol: USP26
USP26 		0.010 GeneticVariation phenotype BEFREE Disruption of ubiquitin specific protease 26 gene causes male subfertility associated with spermatogenesis defects in mice†. 30561524 2019
Entrez Id: 367
Gene Symbol: AR
AR 		0.320 Biomarker phenotype CTD_human Genetic diagnosis in infertile men with numerical and constitutional sperm abnormalities. 18554162 2008
Entrez Id: 367
Gene Symbol: AR
AR 		0.320 Biomarker phenotype CTD_human Genotyping of Israeli infertile men with idiopathic oligozoospermia. 12220434 2002
Entrez Id: 367
Gene Symbol: AR
AR 		0.320 Biomarker phenotype CTD_human Transcriptional profiling of luteinizing hormone receptor-deficient mice before and after testosterone treatment provides insight into the hormonal control of postnatal testicular development and Leydig cell differentiation. 20164437 2010
Entrez Id: 367
Gene Symbol: AR
AR 		0.320 Biomarker phenotype BEFREE In this study we investigated the association of male subfertility with the length of CAG repeats in the androgen receptor. 11792931 2002
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		0.310 Biomarker phenotype CTD_human Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility. 16861746 2006
Entrez Id: 1080
Gene Symbol: CFTR
CFTR 		0.310 Biomarker phenotype CTD_human Novel CFTR missense mutations in Brazilian patients with congenital absence of vas deferens: counseling issues. 17823699 2007
Entrez Id: 4968
Gene Symbol: OGG1
OGG1 		0.310 Biomarker phenotype CTD_human OGG1 Ser326Cys polymorphism interacts with cigarette smoking to increase oxidative DNA damage in human sperm and the risk of male infertility. 23376476 2013
Entrez Id: 1080
Gene Symbol: CFTR
CFTR 		0.310 Biomarker phenotype CTD_human Genetic diagnosis in infertile men with numerical and constitutional sperm abnormalities. 18554162 2008
Entrez Id: 79730
Gene Symbol: NSUN7
NSUN7 		0.300 Biomarker phenotype CTD_human Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. 17442852 2007
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.300 Biomarker phenotype CTD_human Genetic variants in nitric oxide synthase genes and the risk of male infertility in a Chinese population: a case-control study. 25517965 2014
Entrez Id: 346562
Gene Symbol: GNAT3
GNAT3 		0.300 Biomarker phenotype CTD_human Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility. 23818598 2013
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4 		0.300 Biomarker phenotype CTD_human Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders. 30245210 2018
Entrez Id: 5887
Gene Symbol: RAD23B
RAD23B 		0.300 Biomarker phenotype CTD_human Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B. 11809813 2002
Entrez Id: 387712
Gene Symbol: ENO4
ENO4 		0.300 Biomarker phenotype CTD_human Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility. 23446454 2013