Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 81623
Gene Symbol: DEFB126
DEFB126 		0.010 GeneticVariation phenotype BEFREE DEFB126 was reported to contribute to the sialylation on sperm surface and its homozygous mutation was related to male subfertility. 26832966 2016
Entrez Id: 1080
Gene Symbol: CFTR
CFTR 		0.310 AlteredExpression phenotype BEFREE A missense mutation in SLC26A3 is associated with human male subfertility and impaired activation of CFTR. 29079751 2017
Entrez Id: 2054
Gene Symbol: STX2
STX2 		0.300 Biomarker phenotype CTD_human A new ENU-induced mutant mouse with defective spermatogenesis caused by a nonsense mutation of the syntaxin 2/epimorphin (Stx2/Epim) gene. 18277055 2008
Entrez Id: 339168
Gene Symbol: TMEM95
TMEM95 		0.010 GeneticVariation phenotype BEFREE A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle. 24391514 2014
Entrez Id: 1811
Gene Symbol: SLC26A3
SLC26A3 		0.040 Biomarker phenotype BEFREE A putative role of a primary anion exchange defect of SLC26A3 in male subfertility and the decline of renal function due to chronic dehydration deserve further characterization. 16641574 2006
Entrez Id: 5428
Gene Symbol: POLG
POLG 		0.300 Biomarker phenotype CTD_human Alpers syndrome with prominent white matter changes. 17923349 2008
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2 		0.010 AlteredExpression phenotype BEFREE Among adipokines the newly characterized chemokine chemerin is suggested to influence testosterone production in males, but whether serum levels associate with testosterone or male subfertility has not yet been reported. 30304526 2018
Entrez Id: 867
Gene Symbol: CBL
CBL 		0.300 Biomarker phenotype CTD_human Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl. 16301331 2005
Entrez Id: 196
Gene Symbol: AHR
AHR 		0.300 Biomarker phenotype CTD_human Assessment of an association between an aryl hydrocarbon receptor gene (AHR) polymorphism and risk of male infertility. 21613234 2011
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2 		0.300 Biomarker phenotype CTD_human Assessment of the reproductive toxicity of inhalation exposure to ethyl tertiary butyl ether in male mice with normal, low active and inactive ALDH2. 24448831 2014
Entrez Id: 5444
Gene Symbol: PON1
PON1 		0.300 Biomarker phenotype CTD_human Association between male infertility and genetic variability at the PON1/2 and GSTM1/T1 gene loci. 21561808 2011
Entrez Id: 3972
Gene Symbol: LHB
LHB 		0.300 Biomarker phenotype CTD_human Association of molecular variants of luteinizing hormone with male infertility. 10739843 2000
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		0.310 Biomarker phenotype CTD_human Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility. 16861746 2006
Entrez Id: 4548
Gene Symbol: MTR
MTR 		0.300 Biomarker phenotype CTD_human Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility. 16861746 2006
Entrez Id: 4552
Gene Symbol: MTRR
MTRR 		0.300 Biomarker phenotype CTD_human Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility. 16861746 2006
Entrez Id: 3237
Gene Symbol: HOXD11
HOXD11 		0.300 Biomarker phenotype CTD_human Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. 7925020 1994
Entrez Id: 8556
Gene Symbol: CDC14A
CDC14A 		0.300 Biomarker phenotype CTD_human CDC14A phosphatase is essential for hearing and male fertility in mouse and human. 29293958 2018
Entrez Id: 2023
Gene Symbol: ENO1
ENO1 		0.300 Biomarker phenotype CTD_human Comparative proteomics reveals the underlying toxicological mechanism of low sperm motility induced by iron ion radiation in mice. 27460355 2016
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4 		0.300 Biomarker phenotype CTD_human Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders. 30245210 2018
Entrez Id: 8755
Gene Symbol: ADAM6
ADAM6 		0.010 GeneticVariation phenotype BEFREE Deletion of Adam6 in Mus musculus leads to male subfertility and deficits in sperm ascent into the oviduct. 30289441 2019
Entrez Id: 5887
Gene Symbol: RAD23B
RAD23B 		0.300 Biomarker phenotype CTD_human Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B. 11809813 2002
Entrez Id: 83844
Gene Symbol: USP26
USP26 		0.010 GeneticVariation phenotype BEFREE Disruption of ubiquitin specific protease 26 gene causes male subfertility associated with spermatogenesis defects in mice†. 30561524 2019
Entrez Id: 387712
Gene Symbol: ENO4
ENO4 		0.300 Biomarker phenotype CTD_human Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility. 23446454 2013
Entrez Id: 1811
Gene Symbol: SLC26A3
SLC26A3 		0.040 Biomarker phenotype BEFREE Disruption of the SLC26A3-mediated anion transport is associated with male subfertility. 16412765 2006
Entrez Id: 161582
Gene Symbol: DNAAF4
DNAAF4 		0.300 Biomarker phenotype CTD_human DYX1C1 is required for axonemal dynein assembly and ciliary motility. 23872636 2013