Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2075650
rs2075650
0.900 GeneticVariation BEFREE The AA genotype of the aging-related single-nucleotide polymorphism (SNP) rs2075650 in TOMM40 has been associated with longevity, while the AG and GG genotypes are associated with an increased risk of Alzheimer's disease. 31318836

2020

dbSNP: rs75932628
rs75932628
0.900 GeneticVariation BEFREE Our results support the consensus that the R47H variant is significantly associated with AD. 31513029

2020

dbSNP: rs2075650
rs2075650
0.900 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644

2019

dbSNP: rs2075650
rs2075650
0.900 GeneticVariation BEFREE The SNPs rs2075650 and rs4420638 were linked to the most replications within a single reclassified phenotype or very similar reclassified phenotypes; both were associated with Alzheimer's disease (AD). 29942042

2019

dbSNP: rs3764650
rs3764650
0.900 GeneticVariation BEFREE Thus, in African Americans the interactive effects of ABCA7 rs3764650 and aerobic fitness likely compound overall ABCA7-related AD risk, and may contribute to health disparities whereby African Americans are at a higher risk for dementia, with double the prevalence of AD. 31024289

2019

dbSNP: rs3851179
rs3851179
0.900 GeneticVariation BEFREE rs3851179 and rs541458 appear to be associated with decreased AD risk. 31385771

2019

dbSNP: rs3865444
rs3865444
0.900 GeneticVariation GWASCAT Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project. 31473137

2019

dbSNP: rs3865444
rs3865444
A 0.900 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256

2019

dbSNP: rs3865444
rs3865444
0.900 GeneticVariation BEFREE These results suggested that the two CD33 common variants (rs3826656 and rs3865444) influenced volumes and atrophy rates of AD-related brain regions in non-demented elders. 30883353

2019

dbSNP: rs405509
rs405509
T 0.900 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644

2019

dbSNP: rs405509
rs405509
0.900 GeneticVariation BEFREE We tested if the ε4 major isoform of the APOE gene and rs405509 and rs440446 promoter and intron-1 polymorphisms predicted risk of any dementia or Alzheimer's disease with diagnoses derived from the Hospital Discharge and Causes of Death Registers in 1453 participants of the Helsinki Birth Cohort Study. 30293724

2019

dbSNP: rs405509
rs405509
0.900 GeneticVariation BEFREE Education, sex, and the APOE-rs405509 variant are associated with Alzheimer's disease and cognitive performance. 31100889

2019

dbSNP: rs405509
rs405509
0.900 GeneticVariation BEFREE Among ε4/ε4 individuals, AD risk increased substantially in a dose-dependent manner with the number of <i>APOE</i> promoter SNP rs405509 <i>T</i> alleles in EastAs <i>(TT</i>: OR (odds ratio) = 27.02, <i>p</i> = 8.80 × 10<sup>-94</sup>; <i>GT</i>: OR = 15.87, <i>p</i> = 2.62 × 10<sup>-9</sup>) and EuroAs (<i>TT</i>: OR = 18.13, <i>p</i> = 2.69 × 10<sup>-108</sup>; <i>GT</i>: OR = 12.63, <i>p</i> = 3.44 × 10<sup>-64</sup>), and rs405509-<i>T</i> homozygotes had a younger onset and more severe cortical atrophy than those with <i>G</i>-allele. 31426376

2019

dbSNP: rs63750264
rs63750264
APP
0.900 GeneticVariation BEFREE Dermal fibroblasts were obtained from a 55 year old male Сaucasian familial Alzheimer's disease (AD) patient carrying heterozygous V717I mutation in the APP gene. 30851551

2019

dbSNP: rs63750264
rs63750264
APP
0.900 GeneticVariation BEFREE In this study, a novel mutation in APP gene, Val669Leu ("Seoul APP"), was reported in a Korean female patient with Alzheimer's disease. 31623876

2019

dbSNP: rs6656401
rs6656401
CR1
0.900 GeneticVariation GWASCAT Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project. 31473137

2019

dbSNP: rs6656401
rs6656401
CR1
0.900 GeneticVariation GWASCAT Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis. 30805717

2019

dbSNP: rs6656401
rs6656401
CR1
A 0.900 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256

2019

dbSNP: rs744373
rs744373
0.900 GeneticVariation BEFREE Post-mortem and in vitro studies suggest that BIN1-associated AD risk is mediated by increased tau pathology but whether rs744373 is associated with increased tau pathology in vivo is unknown. 30992433

2019

dbSNP: rs75932628
rs75932628
0.900 GeneticVariation BEFREE Three variants in TREM2 (rs75932628 (R47H), rs2234255 (H157Y), and rs143332484 (R62H)) were significantly associated with AD risk, but the similar associations between rs104894002 (Q33X), rs2234253 (T96K), rs142232675 (D87N), rs2234256 (L211P), and AD were not proven. 30883352

2019

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE In a multicenter case-control association study, we studied the SNPs rs11136000 (clusterin, CLU), rs541458 (phosphatidylinositol binding clatrin assembly protein, PICALM), and rs1554948 (transcription factor A, and tyrosine kinase, non-receptor, 1, TNK1) according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients. 28631188

2018

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE The significant association between rs11136000 and AD in the pooled population was found under all the models. 29396813

2018

dbSNP: rs11136000
rs11136000
CLU
0.900 GeneticVariation BEFREE Similarly, we identified that the minor allele variant of rs11136000 significantly decrease AD risk in Caucasian ethnicity using the allele, dominant and recessive model. 30038359

2018

dbSNP: rs2075650
rs2075650
0.900 GeneticVariation GWASCAT Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses. 29107063

2018

dbSNP: rs2075650
rs2075650
0.900 GeneticVariation BEFREE Minor variants: rs10524523-L, rs4420638-G, rs2075650-G were significantly overrepresented in AD. 30443289

2018