|
rs10499194
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no association was found for rs10499194 in a Swedish cohort with early arthritis.
|
19366996 |
2010 |
|
rs17197936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A harmful association was observed between the minor allele of rs17197936 and 2 clinical traits, count of joints with active arthritis and count of joints with pain on motion/tenderness, in patients with extended oligoarthritis.
|
25236364 |
2014 |
|
rs1477353313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To assess the association between the tumour necrosis factor receptor 2 (TNFR2) 196 M/R single-nucleotide polymorphism and rheumatoid arthritis (RA) severity by taking advantage of the extremes of phenotype that exist in arthritis.
|
15252214 |
2004 |
|
rs2070600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response.
|
12070776 |
2002 |
|
rs7033979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The two arthritis-susceptible candidate SNPs, rs7775 (p.Arg324Gly) in the FRZB gene and rs7033979 in the ASPN gene, showed associations with KBD (OR = 1.568, P = 4 × 10<sup>-3</sup> and OR = 0.744, P = 8 × 10<sup>-3</sup>, respectively).
|
28651521 |
2017 |
|
rs13277113
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms of rs13277113 in NCF2 gene were associated with arthritis and autoantibody production, but not disease risk, of SLE in Chinese population.
|
20842512 |
2011 |
|
rs6074028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype 2 had a protective effect on LN (OR = 0.47, P = 0.01, Pcorr = 0.05) in the recessive model while rs73115010, rs6074028 and haplotype 3 (ACGTCGG) resulted in increased risk of arthritis in the recessive model (OR = 2.87, 2.76 and 2.46, P = 0.002, 0.004 and 0.01, Pcorr = 0.009, 0.02 and 0.05, respectively).
|
23256180 |
2013 |
|
rs73115010
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype 2 had a protective effect on LN (OR = 0.47, P = 0.01, Pcorr = 0.05) in the recessive model while rs73115010, rs6074028 and haplotype 3 (ACGTCGG) resulted in increased risk of arthritis in the recessive model (OR = 2.87, 2.76 and 2.46, P = 0.002, 0.004 and 0.01, Pcorr = 0.009, 0.02 and 0.05, respectively).
|
23256180 |
2013 |
|
rs2501432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In humans, the nonsynonymous mutation Q63R, the most common variant of the CB2 receptor, has been found to be associated with multiple diseases, including idiopathic arthritis, obesity, and celiac diseases.
|
29694791 |
2018 |
|
rs35761398
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In humans, the nonsynonymous mutation Q63R, the most common variant of the CB2 receptor, has been found to be associated with multiple diseases, including idiopathic arthritis, obesity, and celiac diseases.
|
29694791 |
2018 |
|
rs879761216
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In humans, the nonsynonymous mutation Q63R, the most common variant of the CB2 receptor, has been found to be associated with multiple diseases, including idiopathic arthritis, obesity, and celiac diseases.
|
29694791 |
2018 |
|
rs1057523354
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1057519090
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs28936375
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs2234693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conclusions Minor allele rs2234693-C was associated with renal and cutaneous involvement, as well as the absence of arthritis, anti-ANA and anti-RNP autoantibodies.
|
27681518 |
2017 |
|
rs1385889785
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that female sex, colonic involvement, and the AA genotype at -110 G>A were associated with increased risk of both subtypes of PA, although the association appears to be stronger for arthritis than for arthralgia.
|
19235910 |
2009 |
|
rs204989
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GPSM3 deficiency protects mice from inflammatory arthritis and, in humans, GPSM3 single-nucleotide polymorphisms (SNPs) are inversely associated with the risk of rheumatoid arthritis development; recently, these polymorphisms were linked to one particular SNP (rs204989) that decreases GPSM3 transcript abundance.
|
27307211 |
2016 |
|
rs204989
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Previous genome-wide association studies have highlighted single-nucleotide polymorphisms (SNPs; rs204989 and rs204991) in a region upstream of the GPSM3 transcription start site as being inversely correlated to the prevalence of rheumatoid arthritis (RA)-this association is supported by the protection afforded to Gpsm3-deficient mice in models of inflammatory arthritis.
|
26821282 |
2016 |
|
rs204991
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Previous genome-wide association studies have highlighted single-nucleotide polymorphisms (SNPs; rs204989 and rs204991) in a region upstream of the GPSM3 transcription start site as being inversely correlated to the prevalence of rheumatoid arthritis (RA)-this association is supported by the protection afforded to Gpsm3-deficient mice in models of inflammatory arthritis.
|
26821282 |
2016 |
|
rs1800562
|
|
|
0.080 |
GeneticVariation |
BEFREE |
There was no association between the presence of HFE mutations and the prevalence of self-reported, doctor-diagnosed arthritis (C282Y/wild type (WT) adjusted OR = 1.041 (95% confidence interval (CI) 0.68-1.61), H63D/WT OR = 0.76 (95% CI 0.53-1.08), C282Y/C282Y OR = 0.39 (95% CI 0.04-3.63), C282Y/H 63D OR = 0.808 (95% CI 0.27-2.42), H63D/H63D OR = 0.419 (95% CI 0.13-1.36)).
|
16638105 |
2006 |
|
rs1800562
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The 124 C282Y homozygotes who filled out the written questionnaire and the 17 C282Y homozygotes who completed the physician double-blind interview reported no significantly higher rates of arthritis or joint pain, abdominal pain, arrhythmias, darkening of skin, or other symptoms traditionally associated with hemochromatosis compared with the 22,429 wild-type controls who filled out the written questionnaire and 29 wild-type controls who completed the double-blind interview.
|
12059121 |
2002 |
|
rs1800562
|
|
|
0.080 |
GeneticVariation |
BEFREE |
All previously undiagnosed C282Y homozygotes (35 male, 67 female) and all HFE wild-types (131 male, 160 female) with baseline and follow-up SF concentrations <1000 microg/L were assessed for HH-associated signs and symptoms including abnormal second/third metacarpophalangeal joints (MCP2/3), raised liver enzymes, hepatomegaly, and self-reported liver disease, fatigue, diabetes mellitus, and use of arthritis medication.
|
20583211 |
2010 |
|
rs1800562
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Hereditary hemochromatosis (HH) is a genetic disease associated with iron overload, in which individuals homozygous for the mutant C282Y HFE associated allele are at risk of developing liver disease, diabetes and arthritis.
|
17904763 |
2008 |
|
rs1800562
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These data suggest that most of the C282Y homozygotes occurred in this arthritis group by chance and that their arthritis was incidental to their HFE genotype.
|
11886966 |
2002 |
|
rs1800562
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In Northern-European ancestry populations, HFE gene C282Y mutations are relatively common (0.3%-0.6% rare homozygote prevalence) and associated with excessive iron absorption, fatigue, diabetes, arthritis, and liver disease, especially in men.
|
30657865 |
2019 |