|
rs180558
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases.
|
31596875 |
2019 |
|
rs4129294
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases.
|
31596875 |
2019 |
|
rs58999906
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases.
|
31596875 |
2019 |
|
rs60603343
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases.
|
31596875 |
2019 |
|
rs1063539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs266729, rs2241766, rs2082940 and rs1063539 in the <i>AD</i> gene and rs7539542 and rs12342 in the <i>ADR</i> gene are possibly not associated with genetic susceptibility to RA, but the <i>A</i><i>D</i> gene rs1063539 locus was possibly associated with anti-CCP in RA female patients.
|
31563887 |
2020 |
|
rs12342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs266729, rs2241766, rs2082940 and rs1063539 in the <i>AD</i> gene and rs7539542 and rs12342 in the <i>ADR</i> gene are possibly not associated with genetic susceptibility to RA, but the <i>A</i><i>D</i> gene rs1063539 locus was possibly associated with anti-CCP in RA female patients.
|
31563887 |
2020 |
|
rs2082940
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs266729, rs2241766, rs2082940 and rs1063539 in the <i>AD</i> gene and rs7539542 and rs12342 in the <i>ADR</i> gene are possibly not associated with genetic susceptibility to RA, but the <i>A</i><i>D</i> gene rs1063539 locus was possibly associated with anti-CCP in RA female patients.
|
31563887 |
2020 |
|
rs7539542
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs266729, rs2241766, rs2082940 and rs1063539 in the <i>AD</i> gene and rs7539542 and rs12342 in the <i>ADR</i> gene are possibly not associated with genetic susceptibility to RA, but the <i>A</i><i>D</i> gene rs1063539 locus was possibly associated with anti-CCP in RA female patients.
|
31563887 |
2020 |
|
rs2075876
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Single nucleotide variants (SNVs) such as rs878081C/T (Ser196Ser) and rs2075876G/T at this locus have been associated with susceptibility to rheumatoid arthritis, mainly in Asian populations, but its role in systemic lupus erythematosus (SLE) has not been documented.
|
31563273 |
2019 |
|
rs878081
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Single nucleotide variants (SNVs) such as rs878081C/T (Ser196Ser) and rs2075876G/T at this locus have been associated with susceptibility to rheumatoid arthritis, mainly in Asian populations, but its role in systemic lupus erythematosus (SLE) has not been documented.
|
31563273 |
2019 |
|
rs1063320
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study aimed at examining the impact of 14 base pair (bp) ins/del (rs66554220) and +3142G>C (rs1063320) polymorphisms and correlating these with soluble HLA-G (sHLA-G) levels to understand the susceptibility to RA in our sample cohort.
|
31549885 |
2020 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Regarding the rs6920220 SNP, we observed a significant association of the variant allele with SLE (<i>P</i> = 0.03, OR = 1.53), pSS (<i>P</i> = 0.016, OR = 1.69), and RA (<i>P</i> = 0.0001, OR = 2.35) susceptibility.
|
31534975 |
2019 |
|
rs117026326
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variant rs117026326 upstream of the general transcription factor II-I (GTF2I) has been associated with primary Sjögren's syndrome, SLE and RA in East Asian populations.
|
31520790 |
2019 |
|
rs4644
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant association of three SNPs i.e. rs1009977, rs4644, and rs74050921 along with elevated galectin-3 levels were observed with susceptibility towards RA.
|
31514073 |
2019 |
|
rs74050921
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant association of three SNPs i.e. rs1009977, rs4644, and rs74050921 along with elevated galectin-3 levels were observed with susceptibility towards RA.
|
31514073 |
2019 |
|
rs2069705
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, we verified higher IL-6 value in the RA patients than healthy control group (p = 0.007) and an association between high IL-6 levels and increased CDAI (r = 0.4648, p = 0.0015); DAS 28 (r = 0.3933, p= 0.0091), presence of bone erosions (r = 0.3170, p = 0.0361), ESR levels(r = 0.3041, p = 0.0448) and IFN-γ levels (r = 0.3049, p = 0.0468).Altogether, we suggest that IL10 -1082 (T>C, rs1800896) and INFG -1616(A>G, rs2069705) polymorphisms as well as IL-6 levels alterations may play a role for prognostic and disease follow-up.
|
31494241 |
2020 |
|
rs6822844
|
|
|
0.770 |
GeneticVariation |
BEFREE |
For IL-21, rs6822844 and rs4505848 were described to have significant associations with susceptibility to RA.
|
31454755 |
2020 |
|
rs2275913
|
|
|
0.070 |
GeneticVariation |
BEFREE |
IL-17A rs2275913 and IL-17F rs763780 polymorphisms are significantly associated with susceptibility to RA and with different clinical characteristics of this disease.
|
31454755 |
2020 |
|
rs763780
|
|
|
0.060 |
GeneticVariation |
BEFREE |
IL-17A rs2275913 and IL-17F rs763780 polymorphisms are significantly associated with susceptibility to RA and with different clinical characteristics of this disease.
|
31454755 |
2020 |
|
rs4505848
|
|
|
0.020 |
GeneticVariation |
BEFREE |
For IL-21, rs6822844 and rs4505848 were described to have significant associations with susceptibility to RA.
|
31454755 |
2020 |
|
rs12537
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results identify a novel role of rs12537 in the susceptibility and progression of RA and SLE, possibly through impacting the interaction between miR-181a and MTMR3 leading to increased autophagy.
|
31444373 |
2019 |
|
rs11209026
|
|
|
0.070 |
GeneticVariation |
BEFREE |
A significant association was identified between the rs11209026 polymorphism and RA susceptibility in Caucasians (AA vs. GG: OR = 1.78, 95% CI = 1.02-3.10, P = .04; AA vs. AG + GG: OR = 1.77, 95% CI = 1.02-3.08, P = .04).
|
31430553 |
2020 |
|
rs1343151
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Furthermore, the meta-analysis revealed a significant association between the rs1343151 polymorphism and RA susceptibility in Caucasians (C vs. T: OR = 0.91, 95% CI = 0.87-0.96, P = .0004).
|
31430553 |
2020 |
|
rs10489629
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Additionally, our result showed that the G allele of IL23R/rs10489629 had a significantly increased frequency in RA patients of Caucasians and Asians (A vs. G: OR = 0.92, 95% CI = 0.88-0.97, P = .002; OR = 0.62, 95% CI = 0.44-0.87, P = .006, respectively).
|
31430553 |
2020 |
|
rs3890745
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |