|
rs1217691063
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Some single nucleotide polymorphism (SNP) (G1691A in factor V gene, also called factor V Leiden [FVL], G20210A in prothrombin gene and C677T in methyltetrahydrofolate reductase [MTHFR] gene) have been associated with thrombosis and ocular involvement in BD with controversial results.
|
23207285 |
2013 |
|
rs1217691063
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Association of MTHFR gene C677T mutation with BD has been reported in different populations.
|
23665953 |
2014 |
|
rs1217691063
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The results of this study showed that there was a high association between the MTHFR gene C677T mutation and BD.
|
22773907 |
2012 |
|
rs1217691063
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C).
|
31602349 |
2019 |
|
rs1217691063
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The rates of homozygosity for the MTHFR C677T mutation in the BD and HC groups were 7.5% and 10%, respectively.
|
14504916 |
2003 |
|
rs1799983
|
|
|
0.070 |
GeneticVariation |
BEFREE |
This meta-analysis shows that the eNOS G894T and the 4b/a polymorphisms are not associated with BD in the Turkish and Asian populations.
|
21957880 |
2012 |
|
rs1799983
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The Glu298Asp polymorphism in exon 7 of the eNOS gene seems to be a susceptibility gene for Korean BD and other rheumatic diseases.
|
14583572 |
2003 |
|
rs1799983
|
|
|
0.070 |
GeneticVariation |
BEFREE |
These results suggest that Glu298Asp polymorphism of the NOS3 gene is associated with BD susceptibility in Tunisian patients.
|
25639851 |
2015 |
|
rs1799983
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In this study, we found that Glu298Asp polymorphism of the eNOS gene was associated with BD in Turkish patients.
|
17067432 |
2007 |
|
rs1799983
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Our findings suggest that Glu298Asp polymorphism of eNOS gene is associated with BD susceptibility as well as skin lesions.
|
18718857 |
2008 |
|
rs1799983
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Glu298 --> Asp polymorphism of the eNOS gene does not appear to be associated with the presence of BD in the Turkish population.
|
16463158 |
2006 |
|
rs1799983
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The result showed a decreased frequency of the NOS3/rs1799983 GG genotype and an increased frequency of NOS3/rs1799983 GT genotype in the patients with BD (Bonferroni correction test [Pc]=0.02, odds ratio [OR]=0.74; Pc=2.1×10(-3), OR=1.57, respectively).
|
27114698 |
2016 |
|
rs17375018
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Six SNPs in IL23R-IL12RB2 were found to be associated with BD after Bonferroni correction for multiple testing, the most significant of which were rs17375018 (OR for G allele 1.51, 95% CI 1.27-1.78, P(unadj) = 1.93 × 10(-6) ), rs7517847 (OR for T allele 1.48, 95% CI 1.26-1.74, P(unadj) = 1.23 × 10(-6) ), and rs924080 (OR for T allele 1.29, 95% CI 1.20-1.39, P = 1.78 × 10(-5) ).
|
22378604 |
2012 |
|
rs17375018
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The results also suggested that both rs11209032 AA and rs17375018 GG of IL-23R are predisposing genotypes for BD and that the AGCG haplotype may provide protection against BD.
|
20375120 |
2010 |
|
rs17375018
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Recent studies identified an association between Behcet's disease (BD) and the IL-23R gene polymorphism (rs17375018) in different populations.
|
26222305 |
2015 |
|
rs17375018
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Of these 5 loci, 2 were found to be significantly associated with BD susceptibility: rs17375018 (G vs. A, OR = 1.50, 95% CI: 1.34-1.68, <i>P</i> < .00001) and rs924080 (T vs. C, OR = 1.36, 95% CI: 1.29-1.43, <i>P</i> < .00001).
|
31814470 |
2019 |
|
rs17375018
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The rs17375018 variant in the IL-23R gene seems likely to be a strong susceptibility factor for BD in the Turkish population.
|
25156021 |
2014 |
|
rs3743930
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Fifty-three BD patients who met the International Study Group criteria for BD were analysed for five common MEFV mutations (M694V, V726A, M680I, M694I, and E148Q) using amplification refractory mutation system and polymerase chain reaction (PCR) restriction-digestion testing methods.
|
21623663 |
2011 |
|
rs3743930
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The third mutation, E148Q, however, was not found to be linked with BD (pooled OR: 1.26, 95% CI: 0.69-2.31).
|
26176758 |
2015 |
|
rs3743930
|
|
|
0.050 |
GeneticVariation |
BEFREE |
All BD patients were genotyped using polymerase chain reaction (PCR) and restriction enzyme analysis for the three most common MEFV mutations (M694V, V726A, and E148Q).
|
17454935 |
2007 |
|
rs3743930
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The M694V, V726A and E148Q mutations tended to be more frequent in definite BD (2.6%, 2.6%, and 5.2%, respectively) than in controls (0%, 0%, and 2.2%).
|
10980540 |
2000 |
|
rs3743930
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The frequencies of E148Q and M680I mutations were significantly higher in the BD group (p=0.001, p=0.046, respectively).
|
23973724 |
2013 |
|
rs61752717
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The M694V, V726A and E148Q mutations tended to be more frequent in definite BD (2.6%, 2.6%, and 5.2%, respectively) than in controls (0%, 0%, and 2.2%).
|
10980540 |
2000 |
|
rs61752717
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Furthermore, carriage of the familial Mediterranean fever gene (MEFV) mutation Met694Val, which is known to cause recessively inherited familial Mediterranean fever, conferred BD risk in the Turkish population (OR, 2.65; P = 1.8 × 10(-12)).
|
23633568 |
2013 |
|
rs61752717
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The meta-analysis confirmed that MEFV mutations M694V and M680I were associated with BD.
|
26176758 |
2015 |