|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Age of diagnosis of CRC in HNPCC patients is therefore more complex than that predicted by the R72P TP53 polymorphism alone, suggesting an inter-relationship with other genetic and/or environmental factors.
|
16353134 |
2006 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men.
|
30316510 |
2018 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers.
|
17599946 |
2007 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis.
|
29872345 |
2018 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian population.
|
22393962 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The gene-gene interaction between TP53 Arg72Pro and MDM2 T309G may interact in carcinogenesis of CRC in Chinese, especially in smokers, and this kind of interaction is associated with onset age of CRC.
|
22744426 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggest that R72P variant seems to be associated with high risk for development of CRC but carries low risk for development of UC.
|
20309662 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We aimed to investigate the association between miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms and the risk of CRC.
|
23183747 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Unexpectedly no significant association was found between this potential marker TP53 Arg72Pro and CRC (p > 0.05).
|
25537146 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We did not identify an association between TP53 rs1042522 and colorectal cancer.
|
20615891 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNP rs4938723 and diabetes mellitus (DM) together were associated with an increased CRC risk, but the SNP TP53 Arg72Pro CC with DM showed a protective effect against CRC.
|
24337371 |
2014 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Few reports have investigated the association of two p53 polymorphisms (Arg72Pro and PIN3-A2) with colorectal cancer (CRC) risk, and no previous study has analyzed their role as susceptibility alleles for colorectal adenoma.
|
17374954 |
2006 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use.
|
17622940 |
2007 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer.
|
18988302 |
2008 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study replicated an association of <i>CCAT2</i> rs6983267 with CRC and an interaction between <i>TP53</i> rs1042522 and NSAID in relation to CRC.
|
30841568 |
2019 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among 442 colorectal cancer cases and 904 controls, we observed no significant overall association between p53 Arg72Pro genotype and colorectal cancer (multivariate OR = 1.14, 95% CI = 0.90-1.45).
|
16721787 |
2006 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study.
|
21051533 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population.
|
27901479 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study results revealed that the rs1042522 genotype with the C allele and the rs12947788 genotype with the T allele in TP53 were associated with a decreased CRC risk in patients with Lynch syndrome in Taiwan.
|
27907203 |
2016 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that Arg72Pro SNP is associated with susceptibility to developing CRC in this ethnic Kashmiri population.
|
20449797 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg462Gln in RNASEL are associated with the age of disease onset of colorectal cancer in Lynch syndrome patients.
|
17224235 |
2007 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, heterozygosity and mutant homozygosity as well as the combination of both TP53 Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population.
|
28554075 |
2017 |
|
rs1064795841
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings may shed light on the mechanism of AR in CRC, namely, that the PT harbored the same mutations as the AR and the lesions in both cases harbored the KRAS G13D mutation.
|
30896620 |
2019 |
|
rs1131691003
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men.
|
30316510 |
2018 |